Outcome of duct‐to‐duct vs. Roux‐en‐Y hepaticojejunostomy biliary anastomoses in below 15‐kg pediatric liver transplant recipients

Shaheen, Mohammed F; Alabdulkarim, Moayad; Hamshow, Mohammad; Abdullah, Khalid; O'Hali, Wael

doi:10.1111/petr.12349

Cited by 6 publications

(7 citation statements)

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“…A previous study showed that there was no statistically significant difference in postoperative anastomotic biliary complications between duct-to-duct and Roux-en-Y hepaticojejunostomy biliary re construction in pediatric liver transplant recipients weighing < 15 kg. 14 The HAT is a severe complication following liver transplant with a high risk for short-or long-term graft dysfunction and biliary complications. Early after surgery, HAT has a mortality rate of 50%.…”

Section: Discussionmentioning

confidence: 99%

Untitled

2015

Exp Clin Transplant

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Objectives: Liver transplant is an established curative therapy for children with chronic end-stage liver disease or acute liver failure. In this study, we aimed to evaluate pediatric liver transplant in terms of outcomes, complications, and long-term followup results. Materials and Methods: Pediatric patients who had liver transplant in our institution were included. We retrospectively evaluated demographic features including body weight, Child-Pugh score, etiology of liver disease, graft source, perioperative outcomes, perioperative complications, postoperative complications, and long-term results. Outcomes of treatment of complications and revision transplant were evaluated. Results: Between September 2001 and December 2013, there were 188 pediatric liver transplants performed in our institution. Most grafts (90.9%) were obtained from living-related donors. There were 13 patients (6.9%) who had an intervention because of a hemorrhage postoperatively. Biliary leakage was observed in 33 patients (17.5%) and biliary stricture during follow-up was observed in 32 patients (17%). Thrombosis rates in the hepatic artery and portal vein were 12.3% and 0.5%. Revision transplant was performed in 11 patients (5.8%); reason for revision transplant was rejection in 50% patients. The remaining children were alive with good graft functioning after treatment of complications and revision transplant. The overall 5-and 10-year survival rates were 82.3% and 78.9%. Conclusions:The overall outcomes of pediatric liver transplant at our center are very promising. With improved care of younger children and the combined efforts of the parents and medical team, the number of the children receiving transplants will increase in the future.

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Section: Discussionmentioning

confidence: 99%

Untitled

2015

Exp Clin Transplant

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“…Эволюция методов трансплантации печени привела к улучшению результатов лечения пациентов. В литературе недостаточно данных о результатах использования двух рассматриваемых методов реконструкции желчевыводящих путей при трансплантации печени [10]. Целью этого исследования было сравнить результаты билиарной реконструкции «проток в проток» и гепатикоеюностомии на петле по Ру у детей -реципиентов печени с массой тела менее 15 кг.…”

Section: Abstract: Liver Transplantation Duct-to-duct Biliary Reconstructions Roux-en-y Hepaticojejunostomy Biliary Complicationsunclassified

“…Впоследствии из исследования исключили 46 человек из группы 1 и 43 человека из группы 2. Средний возраст пациентов составил 2,468 ± 1,5711 года (0,5-10), а их средний вес составил 10,403 ± 2,5501 кг (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15). Наиболее частыми заболеваниями, потребовавшими проведения операции, были атрезия желчевыводящих путей (32%), PFIC -прогрессирующий внутрипеченочный холестаз (17,1%), тирозинемия (16%) и синдром Криглера-Найяра (10,5%).…”

Section: результаты исследования дооперационные характеристики пациентовunclassified

“…Overall, 94 patients had duct to duct anastomosis (group 1) from which 46 expired and 87 cases had Roux-en-Y hepaticojejunostomy (group 2) from which 43 cases passed away. The mean age of the patients was 2.468 ± 1.5711 year (0.5-10) and their mean weight was 10.403 ± 2.5501 Kg (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15). The most common underlying diseases were biliary atresia (32%), PFIC (17.1%) tyrosinemia (16%) and Crigler-Najjar (10.5%).…”

Section: Pre-operative Characteristics Of the Patientsmentioning

confidence: 99%

“…The evolution of the field of liver transplantation has resulted in improved patient outcomes. A paucity of data exists for the outcomes of these two techniques [10]. The aim of this study was to compare the outcomes of duct-to-duct vs. Roux-en-Y hepaticojejunostomy biliary anastomoses in pediatric liver transplant recipients below 15-kg.…”

Section: Introductionmentioning

confidence: 99%

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Liver transplantation in pediatric patients under 15 kg; duct-to-duct vs. Roux-en-Y hepaticojejunostomy biliary anastomoses

Dehghani

Ataollahi

Salimi

et al. 2021

RJTAO

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Back ground. Liver transplantation is an effective treatment for acute or chronic liver failure and metabolic liver disease, which is associated with good quality of life in over 80 percent of recipients. We aimed to evaluate outcome of duct-to-duct vs. Roux-en-Y hepaticojejunostomy biliary anastomoses in pediatric liver transplant recipients below 15-kg.Methods. In this single-center retrospective study, all children less than 15 kg that have undergone liver transplantation at Nemazee Hospital Organ Transplant Center affiliated with Shiraz University of Medical Sciences from 2009 till 2019, were enrolled. Over a 10-yr period, 181 liver transplants were performed in patients with two techniques including duct-to-duct (Group 1) vs. Roux-en-Y hepaticojejunostomy biliary anastomoses (Group 2). All data was collected from patients’ medical records, operative notes, and post-transplant follow up notes. Data was analyzed by SPSS software V21.Results. Overall, 94 patients had duct to duct anastomosis (group 1) and 87 cases had Roux-en-Y hepaticojejunostomy (group 2). The mean age of the patients was 2.46 ± 1.5. The most common underlying diseases was biliary atresia (32%). The most prevalent complication after the surgery was infection in both groups. cardiopulmonary problems were significantly higher in group 2 (24.1% vs 4.3%) (p < 0.001). The rate of infection was significantly higher in group 2, as well.Conclusion. Our study showed a relatively high rate of post-operative infection which was the most among patients who had undergone Roux-en-Y hepaticojejunostomy. Except from biliary complications which were mostly observed in DD group, other complications were more common among Roux-en-Y group.

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Liver Transplant Complications

2017

Diagnostic Imaging: Pediatrics

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Outcome of duct‐to‐duct vs. Roux‐en‐Y hepaticojejunostomy biliary anastomoses in below 15‐kg pediatric liver transplant recipients

Cited by 6 publications

References 50 publications

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Liver transplantation in pediatric patients under 15 kg; duct-to-duct vs. Roux-en-Y hepaticojejunostomy biliary anastomoses

Liver Transplant Complications

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