Outcome of assisted reproduction treatment in patients with endometrial thickness less than 7 mm

Kumbak, Banu; Erden, H. Rıfat; Tosun, Süleyman; Akbas, Halit; Uluğ, Ulun; Bahçeci, Mustafa

doi:10.1016/s1472-6483(10)60428-2

Cited by 63 publications

(55 citation statements)

References 28 publications

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“…Kumbak et al [19] indicated that patients with an endometrium <7 mm had a poor outcome, but the pregnancy rate could be improved by increasing the number of transferred embryos. In our study, the group A also have the lowest CPR, although the reason was unclear.…”

Section: Discussionmentioning

confidence: 99%

Influence of endometrial thickness on treatment outcomes following in vitro fertilization/intracytoplasmic sperm injection

Chen

Dai

et al. 2017

Reprod Biol Endocrinol

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BackgroundThe study was designed to investigate the roles of endometrial thickness (EMT) at the day of human chorionic gonadotropin (hCG) administration on pregnancy outcomes in a large patient population.MethodsThis retrospective cohort study included 9,952 patients undergoing their first IVF/ICSI with autologous oocytes from January 2011 to January 2015. Patients were divided into three groups based on the EMT (group A:≤8 mm; group B: 9–14 mm and group C:≥15 mm). Live birth rate (LBR), clinical pregnancy rate (CPR), early miscarriage rate (EMR), and ectopic pregnancy rate (EPR) were analyzed. Additionally, the live birth rate was analyzed for patients with single or double gestational sacs.ResultsSignificant differences (p < 0.05) were detected in the LBRs (30.38%, 45.73% and 54.55% for groups A, B, and C, respectively), CPRs (38.57%, 55.04% and 64.32%, respectively), and EPRs (5.58%, 3.48% and 2.19%, respectively), with thicker endometrial thickness favoring all three parameters. However, no differences were found in the EMRs among the three groups (15.64%, 13.44% and 13.05%, respectively, p > 0.05). After adjusting for female age, body mass index (BMI) and endometrial pattern, the multivariate logistic regression analysis demonstrated that the associations between EMT and LBR (adjusted OR: 2.645; 95% CI 2.020–3.464; p < 0.01), CPR (adjusted OR 2.693 95% CI 2.012–3.605 p < 0.01), and EPR (adjusted OR: 0.298 95% CI 0.101–0.713; p < 0.05) were significant. Additionally, live birth rates in the double gestational sac group were different (p < 0.05) among patients with different EMT (72.73%, 87.28%, and 87.36%, respectively), whereas no difference was found in the single gestational sac group. In the double gestational sac group, LBR was positively correlated with increasing endometrial thickness only in patients with twin pregnancies but not in patients with singletons.ConclusionsOur study shows that endometrial thickness at the day of hCG administration has an effect on LBR, CPR and EPR, with all three parameters increasing with the EMT. Furthermore, successful twin pregnancies are associated with a thicker endometrium.

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Section: Discussionmentioning

confidence: 99%

Influence of endometrial thickness on treatment outcomes following in vitro fertilization/intracytoplasmic sperm injection

Chen

Dai

et al. 2017

Reprod Biol Endocrinol

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“…A number of reports have shown that embryo implantation and clinical pregnancy rates are significantly lower in women with a thin endometrium which is considered to be less able to support implantation and pregnancy. However, we believe that a thin endometrium might also be simply a consequence of POR; women with POR will have lower estradiol levels compared to those with normal or high ovarian response as they have a diminished cohort of recruitable antral follicles, resulting in decreased production of estradiol, which might compromise endometrial improvement.…”

Section: Discussionmentioning

confidence: 87%

“…Both a thin endometrium and the presence of an endometrioma are considered generally as causes of poor reproductive outcome following IVF; however, these two conditions are related to ovarian response. Women with a low ovarian reserve have a diminished cohort of recruitable antral follicles, resulting in decreased estradiol production, in comparison to women with a normal or high ovarian reserve.…”

Section: Introductionmentioning

confidence: 99%

Ovarian response is a better predictor of clinical pregnancy rate following embryo transfer than is thin endometrium or presence of an endometrioma

Neto

Martins

Lima

et al. 2015

Ultrasound Obstet Gynecol

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“…Furthermore, clinical pregnancy was determined not to differ between the artificial cycles and GnRHsupported artificial cycles (44,50,51). Some studies have shown that endometrial thickness positively affects pregnancy rates in FT cycles (39,52,53). Complete downregulation cannot be guaranteed in artificial cycles, and early luteinization may therefore exist in 5% of cases.…”

Section: Which Methods Is Preferable?mentioning

confidence: 99%

Methods for endometrial preparation in frozen-thawed embryo transfer cycles

Kalem

Gürgan

2016

J Turkish German Gynecol Assoc

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Review 168 IntroductionFrozen-thawed (FT) embryo transfer is a procedure used for the storage and transfer of excess embryos obtained during in vitro fertilization (IVF)-intracytoplasmic sperm injection (ICSI) cycles. In recent years, improvements in laboratory conditions and limitations on the number of embryos to be transferred have led to a progressive increase in FT embryo transfer cycles. Another preferred practice to prevent multiple pregnancies in IVF cycles is to transfer a single embryo and freeze all surplus embryos (1). However, the best solution for endometrial preparation in these cycles is still a matter of debate (2). Frozen-thawed embryo transfer prevents embryo waste and increases the probability of pregnancy in a single stimulated cycle. Protocols applied in FT cycles aim for endometrial preparation only and are therefore simpler than complicated protocols that aim to develop many follicles. As the treatment for subfertility increases, so does the importance of FT embryo transfer; however, there is no consensus about which method is the best (3, 4). Pregnancy rates following FT embryo transfer have been found to be higher than those following fresh embryo transfer (5). Further, FT embryo transfer increases the cumulative pregnancy rate and decreases the cost; in addition, it is easy to perform and can be applied in a shorter time duration when compared to repetitive fresh embryo transfers (5). Using frozen excess embryos obtained as a result of the time-totime implementation of in vitro maturation (IVM) in patients with polycystic ovaries, successful pregnancies have been achieved (6). Therefore, studies have concentrated on factors affecting the success rate of FT embryo transfer cycles.Various cycle protocols are used for the preparation of the endometrium in an FT embryo transfer cycle. In one of these procedures, the transfer time is determined either by the natural course of a cycle [i.e., in an ovulatory patient exhibiting a natural (spontaneous) cycle] or by inducing ovulation during the course of a natural cycle. The second procedure involves the artificial preparation of the endometrium through the administration of exogenous estrogen and progesterone, which can be performed with or without the association of a gonadotropin-releasing hormone agonist. In the third procedure, the cycle is stimulated by gonadotropins and ovulation is induced by recombinant-human chorionic gonadotropin (rHcg) or hCG; however, this practice is no longer applied (7,8). Embryo transfer in a natural (spontaneous) cycleBoth embryo and endometrial development have to be synchronized in FT embryo transfer cycles in order to maximize the pregnancy rate (9). This synchronization can be achieved in several ways. The easiest is the endocrinological preparation of the endometrium during the natural cycle using the patient's own follicular sex steroids. In this application, the timing for embryo transfer (ET) is determined by either investigating the spontaneous luteinizing hormone (LH) surge or by the administration o...

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Outcome of assisted reproduction treatment in patients with endometrial thickness less than 7 mm

Cited by 63 publications

References 28 publications

Influence of endometrial thickness on treatment outcomes following in vitro fertilization/intracytoplasmic sperm injection

Influence of endometrial thickness on treatment outcomes following in vitro fertilization/intracytoplasmic sperm injection

Ovarian response is a better predictor of clinical pregnancy rate following embryo transfer than is thin endometrium or presence of an endometrioma

Methods for endometrial preparation in frozen-thawed embryo transfer cycles

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