Outbreak of SARS-CoV2: Pathogenesis of infection and cardiovascular involvement

Amirfakhryan, Hamideh; Safari, Fatemeh

doi:10.1016/j.hjc.2020.05.007

Cited by 40 publications

(28 citation statements)

References 138 publications

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“… 1 Inflammatory over-reaction and cytokine storm are postulated to play a deleterious role in COVID-19 affecting not only the pulmonary but the cardiovascular system as well. 2 As expected, laboratory evidence of myocardial injury has been reported to be adversely related to short-term mortality in COVID-19 patients and therefore could be utilized in patient risk stratification. 3 However, while a wide range of myocardial injury patterns in COVID-19 patients has been reported (e.g.…”

mentioning

confidence: 62%

Impact of colchicine on mortality in patients with COVID-19: A meta-analysis

Vrachatis

Γιαννόπουλος

Giotaki

et al. 2021

Hellenic Journal of Cardiology

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mentioning

confidence: 62%

Impact of colchicine on mortality in patients with COVID-19: A meta-analysis

Vrachatis

Γιαννόπουλος

Giotaki

et al. 2021

Hellenic Journal of Cardiology

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“…The cardiac events reportedly caused by COVID-19 include acute myocardial injury, heart failure, acute coronary syndrome, infarction, and arrhythmia (Lang et al, 2020;Amirfakhryan and Safari, 2021). The hypotheses surrounding cardiovascular involvement in COVID-19 involve direct infection of cardiac cells by SARS-CoV-2, injury mediated by the inflammatory process, reduced oxygen supply, hypoxia, microthrombi, and stress cardiomyopathy (Lang et al, 2020;Amirfakhryan and Safari, 2021). Histopathological analysis of the heart of a patient with COVID-19 revealed cardiac tissue with a fibrin thrombus in a perforating vein associated with myocardial infarction, myocardial necrosis (transmural), and neutrophilic infiltrates (Rapkiewicz et al, 2020).…”

Section: Cardioprotective Effects Of Curcuminmentioning

confidence: 99%

Curcumin as a Potential Treatment for COVID-19

2021

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Coronavirus disease 2019 (COVID-19) is an infectious disease that rapidly spread throughout the world leading to high mortality rates. Despite the knowledge of previous diseases caused by viruses of the same family, such as MERS and SARS-CoV, management and treatment of patients with COVID-19 is a challenge. One of the best strategies around the world to help combat the COVID-19 has been directed to drug repositioning; however, these drugs are not specific to this new virus. Additionally, the pathophysiology of COVID-19 is highly heterogeneous, and the way of SARS-CoV-2 modulates the different systems in the host remains unidentified, despite recent discoveries. This complex and multifactorial response requires a comprehensive therapeutic approach, enabling the integration and refinement of therapeutic responses of a given single compound that has several action potentials. In this context, natural compounds, such as Curcumin, have shown beneficial effects on the progression of inflammatory diseases due to its numerous action mechanisms: antiviral, anti-inflammatory, anticoagulant, antiplatelet, and cytoprotective. These and many other effects of curcumin make it a promising target in the adjuvant treatment of COVID-19. Hence, the purpose of this review is to specifically point out how curcumin could interfere at different times/points during the infection caused by SARS-CoV-2, providing a substantial contribution of curcumin as a new adjuvant therapy for the treatment of COVID-19.

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“…An autopsy series of COVID-19 patients found deep vein thrombosis (DVP) and pulmonary embolism (PE) in 58 and 73% of the cases, respectively, even without clinical suspicion of venous thromboembolism (VTE) 38 , 39 . Acute coronary syndrome/myocardial infarction 40 , 41 and strokes 42 have been associated with critically ill patients. Other events related to macrothromboses have been reported in the bowels 43 and extremities 44 , sometimes with important clinical consequences.…”

Section: Introductionmentioning

confidence: 99%

ACE2 Down-Regulation May Act as a Transient Molecular Disease Causing RAAS Dysregulation and Tissue Damage in the Microcirculatory Environment Among COVID-19 Patients

Ramos¹,

Rattis²,

Ottaviani³

et al. 2021

The American Journal of Pathology

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SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), the etiological agent of COVID-19 (coronavirus disease 2019) and the cause of the current pandemic, produces multiform manifestations throughout the body, causing indiscriminate damage to multiple organ systems, particularly the lungs, heart, brain, kidney, and vasculature. The aim of this review is to provide a new look at the data already available for COVID-19, exploring it as a transient molecular disease that causes negative regulation of ACE-2 (angiotensin-converting enzyme 2) and, consequently, deregulates the renin-angiotensin-aldosterone system (RAAS), promoting important changes in the microcirculatory environment. In addition, the authors seek to demonstrate how these microcirculatory changes may be responsible for the wide variety of injury mechanisms observed in different organs in this disease. This new proposed concept of COVID-19 provides a unifying pathophysiological picture of this infection and offers new insights for a rational treatment strategy to combat this new pandemic.

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Outbreak of SARS-CoV2: Pathogenesis of infection and cardiovascular involvement

Cited by 40 publications

References 138 publications

Impact of colchicine on mortality in patients with COVID-19: A meta-analysis

Impact of colchicine on mortality in patients with COVID-19: A meta-analysis

Curcumin as a Potential Treatment for COVID-19

ACE2 Down-Regulation May Act as a Transient Molecular Disease Causing RAAS Dysregulation and Tissue Damage in the Microcirculatory Environment Among COVID-19 Patients

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