Outbreak of recurrent abdominal cramps associated with Arcobacter butzleri in an Italian school

Vandamme, Peter; Pugina, P; Benzi, G; Etterijck, R Van; Vlaes, L; Kersters, Karel; Butzler, Jean‐Paul; Lior, H.; Lauwers, Sabine

doi:10.1128/jcm.30.9.2335-2337.1992

Cited by 186 publications

(86 citation statements)

References 8 publications

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“…fetus [60,61], C. jejuni subsp. doylei [61], C. concisus [61,62], A. butzleri [63][64][65][66][67][68] and Arcobacter skirrowii [69], have been isolated from human patients with diarrhoea.…”

Section: I C R O B I O L O G Ymentioning

confidence: 99%

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Campylobacter, from obscurity to celebrity

Butzler

2004

Clinical Microbiology and Infection

391

296

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After its successful isolation from stools in the 1970s, Campylobacter jejuni has rapidly become the most commonly recognised cause of bacterial gastroenteritis in man. Reported cases of human campylobacteriosis represent only a small fraction of the actual number. In industrialised countries, the incidence of C. jejuni/Campylobacter coli infections peaks during infancy, and again in young adults aged 15-44 years. Acute self-limited gastrointestinal illness, characterised by diarrhoea, fever and abdominal cramps, is the most common presentation of C. jejuni/C. coli infection. The introduction of selective media has made the diagnosis of Campylobacter enteritis a simple procedure. In general, Campylobacter enteritis is a self-limiting disease which seldom requires antimicrobial therapy, although one in 1000 infections may lead to the Guillain-Barré syndrome. In industrialised countries, most infections are acquired through the handling and consumption of poultry meat. In developing countries, where the disease is confined to young children, inadequately treated water and contact with farm animals are the most important risk factors. Many infections are acquired during travel. Fluoroquinolone resistance has been reported in C. jejuni since the late 1980s in Europe and Asia, and since 1995 in the USA. The use of fluoroquinolones to treat animals used for food has accelerated this trend of resistance. In Australia, where fluoroquinolones have not been licensed for use in food production animals, C. jejuni remains susceptible to fluoroquinolones. The public health burden of Campylobacter spp. other than C. jejuni/C. coli remains unmeasured. Better diagnostic methods may reveal the true health burden of these organisms.

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Section: I C R O B I O L O G Ymentioning

confidence: 99%

“…If a Campylobacter sp. other than C. jejuni is suspected, stool filtration and culture on a nonselective medium, with incubation at 37°C and 42°C, should also be used [61][62][63][64][65][66][67][68][69][70].…”

Section: I C R O B I O L O G Ymentioning

confidence: 99%

Campylobacter, from obscurity to celebrity

Butzler

2004

Clinical Microbiology and Infection

391

296

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“…Acrobacter nitrofigilis is present in the roots of a marsh plant (McClung et al, 1983) and Arcobacter halophilus was isolated from a hypersaline lagoon (Donachie et al, 2005). Other Arcobacter species were found in association with humans and animals: Arcobacter cibarius was isolated from chicken carcasses ; Arcobacter butzleri, Arcobacter skirrowii and A. cryaerophilus were found in foods of animal origin (Kabeya et al, 2004;Scullion et al, 2006) and in the stool of healthy as well as sick animals and humans (Vandamme et al, 1992;Anderson et al, 1993;On et al, 2002;Kabeya et al, 2003;Vandenberg et al, 2005). This mixture of species with very different habitats makes Arcobacter an 'unusual' and probably heterogeneous genus (Vandamme, 2000).…”

Section: Introductionmentioning

confidence: 99%

Arcobacterspp. possess two very short flagellins of which FlaA is essential for motility

Ho¹,

Lipman²,

Wösten³

et al. 2008

FEMS Immunology &Amp; Medical Microbiology

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Like Campylobacter and Helicobacter spp., Arcobacter spp. possess two flagellin genes (flaA and flaB) located adjacent to each other. The aim of this study was to characterize the flagellin proteins of Arcobacter spp., because these proteins are known virulence factors in the Epsilonproteobacteria, to which these three species belong. With the exception of Arcobacter nitrofigilis, Arcobacter flagellins are almost half the size of those in other Epsilonproteobacteria. Arcobacter flagellin proteins lack a large part of the variable central region. The low homology observed among flagellins of different Arcobacter species indicates genetic heterology between the members of this genus. Unlike in other Epsilonproteobacteria, the transcription of flagellin genes is not regulated by s 28 -or s 54 -dependent promoters, which suggests that transcription must be regulated in a different way in Arcobacter spp. Mutational studies revealed that only FlaA is needed for the motility of Arcobacter spp. Quantitative PCR analysis showed that transcription of flaB is higher at 30 1C than at 37 1C. Mutation of flaB had no effect on motility or on flaA transcription while mutation of flaA abolished motility and increased the transcription of flaB. These results underline that the genus Arcobacter is an unusual taxon in the epsilon subdivision of the Proteobacteria.

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“…With regard to potential infection routes, these mainly include drinking of contaminated water (particularly in developing countries with inadequate water supplies), and consumption and handling of contaminated food (primarily raw or undercooked meat) (Ho et al, 2006;Taylor et al, 1991;Wesley, 1996Wesley, , 1997. Nevertheless, contact with pets and person-toperson transmission have also been suggested as potential risk factors for human infections (Fera et al, 2009;Houf et al, 2008;Vandamme et al, 1992).…”

Section: Arcobacter Sppmentioning

confidence: 99%

“…Although an outbreak of recurrent abdominal cramps in a nursery and primary school in Italy in 1983 was associated with Ar. butzleri, with the successive timing of the cases suggesting a person-to-person transmission, no specific food vehicle was identified (Vandamme et al, 1992). Only recently were arcobacters associated with an outbreak of foodborne illness; Ar.…”

Section: Arcobacter Sppmentioning

confidence: 99%