Outbreak of jaundice and hemorrhagic fever in the Southeast of Brazil in 2001: Detection and molecular characterization of yellow fever virus

Filippis, Ana María Bispo de; Nogueira, R. M.; Schatzmayr, Hermann G.; Tavares, Diva S; Jabor, A.V.; Diniz, S.C.M.; Oliveira, Jeferson Carvalhaes de; Moreira, Eliana Furtado; Miagostovich, M P; Costa, Eliane Veiga da; Galler, Ricardo

doi:10.1002/jmv.10226

Cited by 38 publications

(20 citation statements)

References 26 publications

(34 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The occurrence of a gradual increase in the sylvatic circulation of YFV beyond traditional boundaries of the enzootic zone, as those reported in the states of Rio Grande do Sul [Vasconcelos et al, 2003], and in Minas Gerais in 2000 and 2001 [Filippis et al, 2002], was associated with the high mobility of susceptible humans in those regions where the YF is endemic. As the YFV circulates in several regions in Brazil, the presence of A. aegypti was considered to be a real threat for reurbanization of the disease [Travassos da Rosa et al, 2000].…”

Section: Introductionmentioning

confidence: 86%

Detection of a new yellow fever virus lineage within the South American genotype I in Brazil

Souza

Foster

Sallum

et al. 2009

Journal of Medical Virology

View full text Add to dashboard Cite

Nucleotide sequences of two regions of the genomes of 11 yellow fever virus (YFV) samples isolated from monkeys or humans with symptomatic yellow fever (YF) in Brazil in 2000, 2004, and 2008 were determined with the objective of establishing the genotypes and studying the genetic variation. Results of the Bayesian phylogenetic analysis showed that sequences generated from strains from 2004 and 2008 formed a new subclade within the clade 1 of the South American genotype I. The new subgroup is here designated as 1E. Sequences of YFV strains recovered in 2000 belong to the subclade 1D, which comprises previously characterized YFV strains from Brazil. Molecular dating analyses suggested that the new subclade 1E started diversifying from 1D about 1975 and that the most recent 2004-2008 isolates arose about 1985.

show abstract

Section: Introductionmentioning

confidence: 86%

Detection of a new yellow fever virus lineage within the South American genotype I in Brazil

Souza

Foster

Sallum

et al. 2009

Journal of Medical Virology

View full text Add to dashboard Cite

show abstract

“…Since 2000, SYF has been spreading progressively, transcending its usual boundaries and reaching other areas formerly known as enzootic [13][14][15] . The last urban outbreak in Brazil occurred in 1942 4 .…”

Section: Methodsmentioning

confidence: 99%

“…The last urban outbreak in Brazil occurred in 1942 4 . The last autochthonous cases were reported in the State of São Paulo 47 years ago 15 , but in 2000, two autochthonous SYF cases were notified along the border of the State of Minas Gerais 14 . After YF laboratory confirmation in four monkeys from the region of São José do Rio Preto and two confirmed fatal human autochthonous cases in the region of Ribeirão Preto, two expeditions for entomological studies and eco-epidemiological assessment of the likely sites of infection (LSI) were conducted.…”

Section: Methodsmentioning

confidence: 99%

Reemergence of yellow fever: detection of transmission in the State of São Paulo, Brazil, 2008

Moreno

Rocco

Bergo³

et al. 2011

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

INTRODUCTION: Following yellow fever virus (YFV) isolation in monkeys from the São José do Rio Preto region and two fatal human autochthonous cases from the Ribeirão Preto region, State of São Paulo, Brazil, two expeditions for entomological research and eco-epidemiological evaluation were conducted. METHODS: A total of 577 samples from humans, 108 from monkeys and 3,049 mosquitoes were analyzed by one or more methods: virus isolation, ELISA-IgM, RT-PCR, histopathology and immunohistochemical. RESULTS: Of the 577 human samples, 531 were tested by ELISA-IgM, with 3 positives, and 235 were inoculated into mice and 199 in cell culture, resulting in one virus isolation. One sample was positive by histopathology and immunohistochemical. Using RT-PCR, 25 samples were processed with 4 positive reactions. A total of 108 specimens of monkeys were examined, 108 were inoculated into mice and 45 in cell culture. Four virus strains were isolated from Alouattacaraya. A total of 931 mosquitoes were captured in Sao Jose do Rio Preto and 2,118 in Ribeirão Preto and separated into batches. A single isolation of YFV was derived from a batch of 9 mosquitoes Psorophoraferox, collected in Urupês, Ribeirão Preto region. A serological survey was conducted with 128 samples from the municipalities of São Carlos, Rincão and Ribeirão Preto and 10 samples from contacts of patients from Ribeirão Preto. All samples were negative by ELISA-IgM for YFV. CONCLUSIONS: The results confirm the circulation of yellow fever, even though sporadic, in the Sao Paulo State and reinforce the importance of vaccination against yellow fever in areas considered at risk.

show abstract

“…The SYF has been gradually expanding its territory, which led to a gradual increase in cases near the traditional boundaries of the enzootic area, as well as in the states of Rio Grande do Sul 9 and Minas Gerais in 2000 and 2001, respectively 8 . The high mobility of human populations in such regions of transmission, associated with the spread of the Aedes aegypti in Brazil 25 , represents a real risk for the reintroduction of YFV in the urban environment.…”

Section: Introductionmentioning

confidence: 99%

Isolation of yellow fever virus (YFV) from naturally infectied Haemagogus (Conopostegus) leucocelaenus (diptera, cukicudae) in São Paulo State, Brazil, 2009

Souza

Petrella

Coimbra

et al. 2011

Rev. Inst. Med. trop. S. Paulo

View full text Add to dashboard Cite

SUMMARYAfter detecting the death of Howlers monkeys (genus Alouatta) and isolation of yellow fever virus (YFV) in Buri county, São Paulo, Brazil, an entomological research study in the field was started. A YFV strain was isolated from newborn Swiss mice and cultured cells of Aedes albopictus -C6/36, from a pool of six Haemagogus (Conopostegus) leucocelaenus (Hg. leucocelaenus) mosquitoes (Dyar & Shannon) collected at the study site. Virus RNA fragment was amplified by RT-PCR and sequenced. The MCC Tree generated showed that the isolated strain is related to the South American I genotype, in a monophyletic clade containing isolates from recent 2008-2010 epidemics and epizootics in Brazil. Statistical analysis commonly used were calculated to characterize the sample in relation to diversity and dominance and indicated a pattern of dominance of one or a few species. Hg. leucocelaenus was found infected in Rio Grande do Sul State as well. In São Paulo State, this is the first detection of YFV in Hg. leucocelaenus.

show abstract

Outbreak of jaundice and hemorrhagic fever in the Southeast of Brazil in 2001: Detection and molecular characterization of yellow fever virus

Cited by 38 publications

References 26 publications

Detection of a new yellow fever virus lineage within the South American genotype I in Brazil

Detection of a new yellow fever virus lineage within the South American genotype I in Brazil

Reemergence of yellow fever: detection of transmission in the State of São Paulo, Brazil, 2008

Isolation of yellow fever virus (YFV) from naturally infectied Haemagogus (Conopostegus) leucocelaenus (diptera, cukicudae) in São Paulo State, Brazil, 2009

Contact Info

Product

Resources

About