Osteoradionecrosis: A new concept of its pathophysiology

Risk assessment for osteoradionecrosis of the jaws in patients with head and neck cancer

“…In the present study, ORN was observed more frequently in older individuals. This observation is in agreement with the findings by Marx et al [9]. We found a majority of patients with ORN had a primary tumor site in the buccal mucosa and alveolus.…”

Risk assessment for osteoradionecrosis of the jaws in patients with head and neck cancer

“…In the present study, ORN was observed more frequently in older individuals. This observation is in agreement with the findings by Marx et al [9]. We found a majority of patients with ORN had a primary tumor site in the buccal mucosa and alveolus.…”

Implant-Supported Oral Rehabilitation in Head and Neck Cancer Patients: A 20-Year Single-Center Study (2005–2024)

“…This aligns with several recent studies that have also reported no major impact of radiation on implant survival when confounding factors are controlled [57]. For example, a meta-analysis focusing on 2007-2013 data found no significant difference between implants in irradiated vs. native bone [58], which mirrors our findings. On the other hand, older reports in the literature and some meta-analyses have shown a clear effect of radiation, with reported survival rates of ~84-92% in irradiated cases vs. ~95% in non-irradiated [19,31,[59][60][61].…”

Suppurative osteomyelitis, bisphosphonate induced osteonecrosis, osteoradionecrosis: a blinded histopathologic comparison and its implications for the mechanism of each disease

“…By contrast, BIONJ showed empty marrow spaces devoid of all cellular elements and normal cellular products. ORNJ showed significant marrow fibrosis and a paucity of cells as well as the ghosts of old blood vessels consistent with the concept of hypocellular-hypovascularhypoxic tissue previously described 7 . Suppurative osteomyelitis was the only one of these three diseases in which osteoclasts were found, and whilst ORNJ demonstrated a nonviable periosteum and no evidence of reactive bone, both SOJ and BIONJ did show viable periosteum and even reactive bone in many cases.…”

Risk assessment for osteoradionecrosis of the jaws in patients with head and neck cancer

“…In the present study, ORN was observed more frequently in older individuals. This observation is in agreement with the findings by Marx et al [9]. We found a majority of patients with ORN had a primary tumor site in the buccal mucosa and alveolus.…”

Implant-Supported Oral Rehabilitation in Head and Neck Cancer Patients: A 20-Year Single-Center Study (2005–2024)

“…This aligns with several recent studies that have also reported no major impact of radiation on implant survival when confounding factors are controlled [57]. For example, a meta-analysis focusing on 2007-2013 data found no significant difference between implants in irradiated vs. native bone [58], which mirrors our findings. On the other hand, older reports in the literature and some meta-analyses have shown a clear effect of radiation, with reported survival rates of ~84-92% in irradiated cases vs. ~95% in non-irradiated [19,31,[59][60][61].…”

Suppurative osteomyelitis, bisphosphonate induced osteonecrosis, osteoradionecrosis: a blinded histopathologic comparison and its implications for the mechanism of each disease

“…By contrast, BIONJ showed empty marrow spaces devoid of all cellular elements and normal cellular products. ORNJ showed significant marrow fibrosis and a paucity of cells as well as the ghosts of old blood vessels consistent with the concept of hypocellular-hypovascularhypoxic tissue previously described 7 . Suppurative osteomyelitis was the only one of these three diseases in which osteoclasts were found, and whilst ORNJ demonstrated a nonviable periosteum and no evidence of reactive bone, both SOJ and BIONJ did show viable periosteum and even reactive bone in many cases.…”

Risk assessment for osteoradionecrosis of the jaws in patients with head and neck cancer

“…In the present study, ORN was observed more frequently in older individuals. This observation is in agreement with the findings by Marx et al [9]. We found a majority of patients with ORN had a primary tumor site in the buccal mucosa and alveolus.…”

Implant-Supported Oral Rehabilitation in Head and Neck Cancer Patients: A 20-Year Single-Center Study (2005–2024)

“…This aligns with several recent studies that have also reported no major impact of radiation on implant survival when confounding factors are controlled [57]. For example, a meta-analysis focusing on 2007-2013 data found no significant difference between implants in irradiated vs. native bone [58], which mirrors our findings. On the other hand, older reports in the literature and some meta-analyses have shown a clear effect of radiation, with reported survival rates of ~84-92% in irradiated cases vs. ~95% in non-irradiated [19,31,[59][60][61].…”

Suppurative osteomyelitis, bisphosphonate induced osteonecrosis, osteoradionecrosis: a blinded histopathologic comparison and its implications for the mechanism of each disease

“…By contrast, BIONJ showed empty marrow spaces devoid of all cellular elements and normal cellular products. ORNJ showed significant marrow fibrosis and a paucity of cells as well as the ghosts of old blood vessels consistent with the concept of hypocellular-hypovascularhypoxic tissue previously described 7 . Suppurative osteomyelitis was the only one of these three diseases in which osteoclasts were found, and whilst ORNJ demonstrated a nonviable periosteum and no evidence of reactive bone, both SOJ and BIONJ did show viable periosteum and even reactive bone in many cases.…”