Osteoporosis in men

Vilaça, Tatiane; Eastell, Richard; Schini, Marian

doi:10.1016/s2213-8587(22)00012-2

Cited by 104 publications

(73 citation statements)

References 115 publications

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“…According to some relevant literature reports [6][7][8], there are many possible risk factors for osteoporosis in men, including alcoholism, body mass index (BMI), glucocorticoid overdose, hypogonadism, parathyroidism, hyperthyroidism, gastro-intestinal diseases, and hypercalciuria. However, the causal relationships between these risk factors and osteoporosis have not been fully established.…”

Section: Introductionmentioning

confidence: 99%

Causal relationships between sex hormone traits, lifestyle factors, and osteoporosis in men: A Mendelian randomization study

Wang

Cheng²,

Wei³

et al. 2022

PLoS ONE

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Although observational studies have explored factors that may be associated with osteoporosis, it is not clear whether they are causal. Osteoporosis in men is often underestimated. This study aimed to identify the causal risk factors associated with bone mineral density(BMD) in men. Single nucleotide polymorphisms (SNPs) associated with the exposures at the genome-wide significance (p < 5x10-8) level were obtained from corresponding genome-wide association studies (GWASs) and were utilized as instrumental variables. Summary-level statistical data for BMD were obtained from two large-scale UK Biobank GWASs. A Mendelian randomization (MR) analysis was performed to identify causal risk factors for BMD. Regarding the BMD of the heel bone, the odds of BMD increased per 1-SD increase of free testosterone (FT) (OR = 1.13, P = 9.4 × 10−17), together with estradiol (E2) (OR = 2.51, P = 2.3 × 10−4). The odds of BMD also increased with the lowering of sex-hormone binding globulin (SHBG) (OR = 0.87, P = 7.4 × 10−8) and total testosterone (TT) (OR = 0.96, P = 3.2 × 10−2) levels. Regarding the BMD of the lumbar spine, the odds of BMD increased per 1-SD increase in FT (OR = 1.18, P = 4.0 × 10−3). Regarding the BMD of the forearm bone, the odds of BMD increased with lowering SHBG (OR = 0.75, P = 3.0 × 10−3) and TT (OR = 0.85, P = 3.0 × 10−3) levels. Our MR study corroborated certain causal relationships and provided genetic evidence among sex hormone traits, lifestyle factors and BMD. Furthermore, it is a novel insight that TT was defined as a disadvantage for osteoporosis in male European populations.

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Section: Introductionmentioning

confidence: 99%

Causal relationships between sex hormone traits, lifestyle factors, and osteoporosis in men: A Mendelian randomization study

Wang

Cheng²,

Wei³

et al. 2022

PLoS ONE

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“…Although OP is a chronic and age-dependent bone disease, its complications seriously affect the quality of life of osteoporotic patients and bring huge economic burden to the society (27,28). With the increased lifespan of the human population, a higher proportion of the global population will be susceptible to osteoporosis (29)(30)(31).…”

Section: Discussionmentioning

confidence: 99%

Relationship between indices of circulating blood cells and bone homeostasis in osteoporosis

Hao

Guan

et al. 2022

Front. Endocrinol.

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Bone development have been shown to play an important role in regulating hematopoiesis as one major component of bone marrow microenvironment. Recent studies support the notion that there is an intricate relationship between hematopoiesis and bone homeostasis, however, little is known about the alterations in the hematopoietic lineages in pathologic conditions. Using various osteoporotic mouse models, we show here that bone microarchitecture abnormalities alter parameters of peripheral blood cells. The level of white blood cells is dynamics and negatively correlated with bone mineral density during the progression of osteoporosis. Furthermore, our clinical data confirm that osteoporosis is associated with abnormal circulating blood cell counts. These results demonstrated a causal link that osteoporosis is accompanied by the altered circulating blood cells, supporting the idea of a close interplay between hematopoiesis and bone homeostasis. Our study would propose that routine complete blood count might be applied as a potential diagnostic and putative marker for osteoporosis.

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“…Hormone replacement therapy (HRT) has proven effective at preventing bone loss in postmenopausal women. In men [ 63 ], studies have found that testosterone can regulate bone metabolism directly and by being converted to estrogen [ 64 ]. Indeed, inhibition of aromatase, the enzyme responsible for androgen conversion into estrogen, resulted in decreased BMD in male rats [ 65 ].…”

Section: The Regulation Of Bone Remodeling In Health and Osteoporosismentioning

confidence: 99%

Osteoporosis pathogenesis and treatment: existing and emerging avenues

et al. 2022

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Osteoporotic fractures lead to increased disability and mortality in the elderly population. With the rapid increase in the aging population around the globe, more effective treatments for osteoporosis and osteoporotic fractures are urgently required. The underlying molecular mechanisms of osteoporosis are believed to be due to the increased activity of osteoclasts, decreased activity of osteoblasts, or both, which leads to an imbalance in the bone remodeling process with accelerated bone resorption and attenuated bone formation. Currently, the available clinical treatments for osteoporosis have mostly focused on factors influencing bone remodeling; however, they have their own limitations and side effects. Recently, cytokine immunotherapy, gene therapy, and stem cell therapy have become new approaches for the treatment of various diseases. This article reviews the latest research on bone remodeling mechanisms, as well as how this underpins current and potential novel treatments for osteoporosis.

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Osteoporosis in men

Cited by 104 publications

References 115 publications

Causal relationships between sex hormone traits, lifestyle factors, and osteoporosis in men: A Mendelian randomization study

Causal relationships between sex hormone traits, lifestyle factors, and osteoporosis in men: A Mendelian randomization study

Relationship between indices of circulating blood cells and bone homeostasis in osteoporosis

Osteoporosis pathogenesis and treatment: existing and emerging avenues

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