Osteoporosis and Coronary Atherosclerosis in Asymptomatic Postmenopausal Women

Barengolts, Elena; Berman, Mones; Kukreja, Subhash C.; Kouznetsova, Tatiana; Lin, Chun‐Hung; Chomka, Eva V.

doi:10.1007/s002239900419

Cited by 237 publications

(159 citation statements)

References 31 publications

Supporting

Mentioning

136

Contrasting

Unclassified

Order By: Relevance

“…Previously, conflicting results have been reported on the effect of cardiovascular diseases on BMD. Although arterial hypertension was associated with an increased BMD in one study [27], a reduced BMD was found by other investigators in subjects with arterial hypertension, as well as in patients with ischaemic heart diseases [28][29][30][31][32]. Thus, if ischaemic heart diseases cause a reduced BMD, LD may actually affect BMD positively, as we found a similar BMD in subjects treated with LD due to cardiovascular diseases as in healthy nonusers of LD.…”

Section: Study Strengths and Limitationssupporting

confidence: 67%

Effects of long‐term treatment with loop diuretics on bone mineral density, calcitropic hormones and bone turnover

Rejnmark

Vestergaard

Heickendorff

et al. 2005

Journal of Internal Medicine

View full text Add to dashboard Cite

Abstract. Rejnmark L, Vestergaard P, Heickendorff L, Andreasen F, Mosekilde L (Aarhus University Hospital and Aarhus University, Aarhus, Denmark). Effects of long-term treatment with loop diuretics on bone mineral density, calcitropic hormones and bone turnover. J Intern Med 2005; 257: 176-184.Background. Loop diuretics (LD) are widely used in the treatment of cardiovascular diseases and disorders with fluid accumulation. LD are known to increase renal calcium losses and may thereby affect calcium homeostasis and bone metabolism. Objective. We studied to what extent long-term treatment with LD affects calcium homeostasis and bone metabolism. Design and subjects. In a cross-sectional design we compared 140 postmenopausal women treated with a LD for more than 2 years with 140 age-matched women not in diuretic therapy. Results. Treatment with LD was associated with significantly increased urinary calcium, plasma parathyroid hormone (PTH) and 1,25-dihydroxyvitamin D levels. Per 40 mg day )1 of furosemide,

show abstract

Section: Study Strengths and Limitationssupporting

confidence: 67%

Effects of long‐term treatment with loop diuretics on bone mineral density, calcitropic hormones and bone turnover

Rejnmark

Vestergaard

Heickendorff

et al. 2005

Journal of Internal Medicine

View full text Add to dashboard Cite

show abstract

“…Lipids have been shown to accumulate in bones of rats and blood vessels around bone in patients with osteo porosis [22,23] . Osteoporosis has been associated with both atherosclerosis and vascular calcification [24][25][26] . Serum lipid levels may alter bone mineralization.…”

Section: Discussionmentioning

confidence: 99%

High cholesterol diet increases osteoporosis risk via inhibiting bone formation in rats

Sheng

Tang

et al. 2011

Acta Pharmacol Sin

View full text Add to dashboard Cite

Aim: To investigate the effects of high cholesterol diet on the development of osteoporosis and the underlying mechanisms in rats. Methods: Female Sprague-Dawley rats were randomly separated into 3 groups: (1) the high cholesterol fed rats were fed a high cholesterol diet containing 77% normal diet food, 3% cholesterol and 20% lard for 3 months; (2) ovariectomised (OVX) rats were bilaterally ovariectomised and fed a standard diet; and (3) the control rats were fed the standard diet. Bone mineral density (BMD) of the rats was measured using dual-energy X-ray absorptiometry. Serum levels of oestradiol (E2), osteocalcin (BGP) and carboxy-terminal collagen crosslinks (CTX) were measured using ELISA. Gene expression profile was determined with microarray. Mouse osteoblast cells (MC3T3-E1) were used for in vitro study. Proliferation, differentiation and oxidative stress of the osteoblasts were investigated using MTT, qRT-PCR and biochemical methods. Results: In high cholesterol fed rats, the femur BMD and serum BGP level were significantly reduced, while the CTX level was significantly increased. DNA microarray analysis showed that 2290 genes were down-regulated and 992 genes were up-regulated in this group of rats. Of these genes, 1626 were also down-regulated and 1466 were up-regulated in OVX rats. In total, 370 genes were up-regulated in both groups, and 976 genes were down-regulated. Some of the down-regulated genes were found to code for proteins involved in the transforming growth factor beta (TGF-β)/bone morphogenic protein (BMP) and Wnt signaling pathways. The up-regulated genes were found to code for IL-6 and Ager with bone-resorption functions. Treatment of MC3T3-E1 cells with cholesterol (12.5-50 μg/mL) inhibited the cell proliferation and differentiation in vitro in a concentration-dependent manner. The treatment also concentration-dependently reduced the expression of BMP2 and Cbfa1, and increased the oxidative injury in MC3T3-E1 cells. Conclusion:The results suggest a close correlation between hypercholesterolaemia and osteoporosis. High cholesterol diet increases the risk of osteoporosis, possible via inhibiting the differentiation and proliferation of osteoblasts.

show abstract

“…Genetic control of bone mass is polygenic and the specific genes involved are beginning to be enumerated, such as genetic variants/mutations of vitamin D and estrogen receptors (Mitchell & Yerges-Armstrong 2011). Recent attention has been given to atherogenic conditions with low HDL plasma levels as factors compromising bone health, and numerous associations, have been revealed between lower bone mass and cardiovascular diseases (Banks et al 1994, Uyama et al 1997, Barengolts et al 1998, von der Recke et al 1999, Hegsted 2001, Yamaguchi et al 2002, Poli et al 2003, Adami et al 2004, Orozco 2004. In accordance, a positive correlation between plasma HDL levels and bone mass has been reported by epidemiological studies (reviewed in Ackert-Bicknell (2012)), suggesting that, in addition to protecting against atherosclerosis, HDL contribute to a healthy environment for bones.…”

Section: Introductionmentioning

confidence: 99%

Gender- and region-specific alterations in bone metabolism in Scarb1-null female mice

Martineau

Martin-Falstrault

Brissette

et al. 2014

Journal of Endocrinology

View full text Add to dashboard Cite

A positive correlation between plasma levels of HDL and bone mass has been reported by epidemiological studies. As scavenger receptor class B, type I (SR-BI), the gene product of Scarb1, is known to regulate HDL metabolism, we recently characterized bone metabolism in Scarb1-null mice. These mice display high femoral bone mass associated with enhanced bone formation. As gender differences have been reported in HDL metabolism and SR-BI function, we investigated gender-specific bone alterations in Scarb1-null mice by microtomography and histology. We found 16% greater relative bone volume and 39% higher bone formation rate in the vertebrae from 2-month-old Scarb1-null females. No such alteration was seen in males, indicating gender-and region-specific differences in skeletal phenotype. Total and HDL-associated cholesterol levels, as well as ACTH plasma levels, were increased in both Scarb1-null genders, the latter being concurrent to impaired corticosterone response to fasting. Plasma levels of estradiol did not differ between null and WT females, suggesting that the estrogen metabolism alteration is not relevant to the higher vertebral bone mass in female Scarb1-null mice. Constitutively, high plasma levels of leptin along with 2.5-fold increase in its expression in white adipose tissue were measured in female Scarb1-null mice only. In vitro exposure of bone marrow stromal cells to ACTH and leptin promoted osteoblast differentiation as evidenced by increased gene expression of osterix and collagen type I alpha. Our results suggest that hyperleptinemia may account for the gender-specific high bone mass seen in the vertebrae of female Scarb1-null mice.

show abstract

Osteoporosis and Coronary Atherosclerosis in Asymptomatic Postmenopausal Women

Cited by 237 publications

References 31 publications

Effects of long‐term treatment with loop diuretics on bone mineral density, calcitropic hormones and bone turnover

Effects of long‐term treatment with loop diuretics on bone mineral density, calcitropic hormones and bone turnover

High cholesterol diet increases osteoporosis risk via inhibiting bone formation in rats

Gender- and region-specific alterations in bone metabolism in Scarb1-null female mice

Contact Info

Product

Resources

About