Osteopontin Levels are Elevated in Patients with Asthma

Zhao, Jing; Yang, Lian; Fq, Zhao; Tan, P.

doi:10.1177/147323001103900426

Cited by 14 publications

(10 citation statements)

References 37 publications

(27 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the previous study (12), the mean serum OPN levels (15.4 ± 6.2 ng/mL) were relatively low compared to our data and other previous data (14). Commercial ELISA kits are available to determine plasma or serum OPN levels.…”

Section: Discussioncontrasting

confidence: 86%

“…The baseline rise in circulating OPN levels was associated with coronary artery disease with rapid plaque progression (16), asthma (14, 17), and cancer aggressiveness and poor survival (2) in humans. Our data demonstrate that high serum OPN levels were associated with osteoporosis, especially in postmenopausal women, suggesting the role of OPN in bone remodeling.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

High Serum Osteopontin Levels Are Associated with Low Bone Mineral Density in Postmenopausal Women

Cho

Lee

et al. 2013

J Korean Med Sci

View full text Add to dashboard Cite

Osteopontin (OPN) is an acidic, noncollagenous matrix protein produced by the bone and kidneys. It is reportedly involved in bone resorption and formation. We examined the association between serum OPN levels and bone mineral density in postmenopausal women. Premenopausal women (n=32) and postmenopausal women (n=409) participated in the study. We measured serum osteopontin levels and their relationships with bone mineral density and previous total fragility fractures. The postmenopausal women had higher mean serum OPN levels compared to the premenopausal women (43.6±25.9 vs 26.3±18.6 ng/mL; P<0.001). In the postmenopausal women, high serum OPN levels were negatively correlated with mean lumbar bone mineral density (BMD) (r=-0.113, P=0.023). In a stepwise multiple linear regression model, serum OPN levels were associated with BMD of the spine, femoral neck, and total hip after adjustment for age, body mass index, smoking, and physical activity in postmenopausal women. However, serum OPN levels did not differ between postmenopausal women with and without fractures. Postmenopausal women exhibit higher serum OPN levels than premenopausal women and higher serum OPN levels were associated with low BMD in postmenopausal women.

show abstract

Section: Discussioncontrasting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

High Serum Osteopontin Levels Are Associated with Low Bone Mineral Density in Postmenopausal Women

Cho

Lee

et al. 2013

J Korean Med Sci

View full text Add to dashboard Cite

show abstract

“…In several other studies conducted in adult patients with asthma, OPN levels were found to be increased in serum, saliva and BALF. 22,23 Regarding IL-17, our results revealed that the IL-17 levels in asthmatic children were higher than those of the control group. IL-17 expression has been shown to increase in sputum, lung, BALFs, and peripheral blood of asthmatic patients.…”

Section: Discussionmentioning

confidence: 61%

Measurement of Serum Osteopontin and Interleukin-17 in Asthmatic Children in Saudi Arabia

et al. 2015

View full text Add to dashboard Cite

Cytokines play an important role in the pathophysiology of asthma by affecting airway remodeling and allergic reactions. We aimed to measure the serum concentrations of osteopontin (OPN) and interleukin (IL)-17 in a group of asthmatic and normal children to test the association of these two cytokines with the severity of asthma in Saudi children. Our study included 50 asthmatic and 50 normal children. Serum cytokines were measured by ELISA technique. Pulmonary function tests were performed in the asthmatic children. Serum levels of OPN and IL-17 were significantly increased in asthmatic children in comparison to control group. Also, the concentrations of OPN and IL-17 were significantly associated with asthma severity. There was a significant positive correlation between OPN and IL-17 levels. In conclusion, our study suggests that OPN and IL-17 may play a role in childhood asthma and are strongly related to the disease severity.

show abstract

“…Osteopontin (OPN) is a multifunctional cytokine that can be expressed by eosinophils and implicated in allergic airway responses. The levels of OPN were elevated in serum of asthmatic patients, but its concentration did not correlated with disease severity . The chemokine RANTES, a key chemotaxis element in allergic airway inflammation, was significantly increased in patients with severe asthma.…”

Section: Biomarkers In Asthmamentioning

confidence: 90%

“…The levels of OPN were elevated in serum of asthmatic patients, but its concentration did not correlated with disease severity. 60 The chemokine RANTES, a key chemotaxis element in allergic airway inflammation, was significantly increased in patients with severe asthma. The serum level of RANTES was associated with eosinophil count and total serum IgE level and displayed inverse relationships with FEV1.…”

Section: Biomarkers In Bloodmentioning

confidence: 99%

Biomolecular markers in assessment and treatment of asthma

et al. 2014

View full text Add to dashboard Cite

Asthma is a chronic and heterogeneous inflammatory disorder with several different phenotypes. Whereas clinical features of asthma are non-specific and pulmonary function tests are often insensitive, further development is needed for efficient treatment or even early diagnosis. Recently, several airway inflammatory biomarkers have emerged as valuable tools in diagnosis and management of asthma. The analysis of molecular markers of airways inflammation has provided promising and non-invasive techniques that facilitate the detection of disease phenotypes as well as measurement of therapeutic efficacy. Although conventional treatments remain the preferred therapy, they do not adequately control some severe cases of asthma. Novel therapeutic agents have been developed to target various biomarkers involved in the inflammatory responses and have been investigated in patients with asthma. In this article, we summarized the most studied asthma biomarkers, derived from a variety of biological sources including exhaled gases, induced sputum, serum and urine. Likewise, the effects of current anti-inflammatory asthma treatments on inflammatory biomarkers and some promising biomarkers for developing new targeted therapies are also discussed.

show abstract

Osteopontin Levels are Elevated in Patients with Asthma

Cited by 14 publications

References 37 publications

High Serum Osteopontin Levels Are Associated with Low Bone Mineral Density in Postmenopausal Women

High Serum Osteopontin Levels Are Associated with Low Bone Mineral Density in Postmenopausal Women

Measurement of Serum Osteopontin and Interleukin-17 in Asthmatic Children in Saudi Arabia

Biomolecular markers in assessment and treatment of asthma

Contact Info

Product

Resources

About