Osteopontin knockdown suppresses the growth and angiogenesis of colon cancer cells

Abstract

Knockdown of OPN gene expression suppresses colon cancer cell growth, adherence, invasion, and expression of angiogenic factors.

MicroRNA-125a Reduces Proliferation and Invasion of Oral Squamous Cell Carcinoma Cells by Targeting Estrogen-related Receptor α

“…Furthermore, OPN is a well known gene involved in the regulation of proliferation, migration, and invasion of OSCC cells (49). Our results showed that miR-125a-mediated targeting of ESRRA indeed regulates the levels of WNT11 and OPN (Fig.…”

“…Furthermore, Lam et al (47) have shown that targeted inhibition of ESRRA inhibits the expression of SNAI1 (Snail family zinc finger 1) and in turn attenuates epithelial to mesenchymal transition in ovarian cancer cells. The mechanisms underlying these effects can be attributed to the ESRRA-driven regulation of several genes involved in cancer progression and development such as WNT11, CCNE1, OPN, and OPG, which are the crucial genes involved in increasing the proliferative and migratory capacity of cells (17,48,49).…”

Wnt/catenin β1/microRNA 183 predicts recurrence and prognosis of patients with colorectal cancer

“…Areas of decreased incidence include South America, Africa and Asia. The morbidity and mortality of colorectal cancer differs between areas of increased and decreased incidence (5).…”

Interactions between osteopontin and vascular endothelial growth factor: Implications for cancer

“…OPN and VEGF contribute to tumor progression [8,12,19,20,62,[99][100][101][102] and angiogenesis [11,12,16,21,28,37,93,99,100,[103][104][105][106][107][108]. The inhibition of OPN may reduce VEGF levels and suppress tumor progression [85,[109][110][111][112].…”