Osteogenic ability of free perichondreal autografts in canine tibial defects: An experimental study

Arican, Mustafa; Ortatatll, M.; Yiğitarslan, Kürşad; Ceylan, Cengiz

doi:10.1016/s0939-8600(03)80003-2

Cited by 1 publication

(1 citation statement)

References 28 publications

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“…The remodeling phase is the longest (it may require 6-9 years in adults) and aims to reestablish the skeletal integrity [50,51]. The reparative phase is characterized by the development of an organized fibrous mass [52] in a process that recapitulates the embryonic intramembranous and endochondral ossifications [53,54,55]. This soft or fibrous callus will bond the broken ends [24] and guarantee the mechanical stability of the injured area [56].…”

Section: Discussionmentioning

confidence: 99%

Below the Callus Surface: Applying Paleohistological Techniques to Understand the Biology of Bone Healing in Skeletonized Human Remains

Assis

Keenleyside

2016

Pathobiology

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Objectives: Bone trauma is a common occurrence in human skeletal remains. Macroscopic and imaging scrutiny is the approach most currently used to analyze and describe trauma. Nevertheless, this line of inquiry may not be sufficient to accurately identify the type of traumatic lesion and the associated degree of bone healing. To test the usefulness of histology in the examination of bone healing biology, we used an integrative approach that combines gross inspection and microscopy. Materials and Methods: Six bone samples belonging to 5 adult individuals with signs of bone trauma were collected from the Human Identified Skeletal Collection from the Museu Bocage (Lisbon, Portugal). Previous to sampling, the lesions were described according to their location, morphology, and healing status. After sampling, the bone specimens were prepared for plane light and polarized light analysis. Results: The histological analysis was pivotal: (1) to differentiate between types of traumatic lesions; (2) to ascertain the posttraumatic interval, and (3) to diagnose other associated pathological conditions. Conclusion: The outer surface of a bone lesion may not give a complete picture of the biology of the tissue's response. Accordingly, microscopic analysis is essential to differentiate, characterize, and classify trauma signs.

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