Osteogenesis Imperfecta

Abstract

Twelve families with 29 patients showing various patterns of osteogenesis imperfecta are described, along with the genetic, pathological, and clinical features. No abnormal blochemical features were found. It has been shown that the best treatment is prophylactic (such as intramedullary nailingy or supportive. There was no remarkable improvement from any form of medical treatment. These data are compared to those of other authors.

Osteogenic sarcoma complicating osteogenesis imperfecta tarda

“…of a m o r e t h a n c o i n c i d e n t a l c o n c u r r e n c e , c a n n o t be a n s w e r e d [3,8]. A s s u m i n g s y n t r o p i s m a n d a s s u m i n g a causal r e l a t i o n s h i p b e t w e e n the two disorders, multiple fractures a n d i m p l a n t a t i o n of metallic osteosynthetic devices have b e e n i n c r i m i n a t e d as precipitating factors [5].…”

“…Osteogenesis imperfecta tarda (o. i. t.) is a rare, and in most instances autosomaldominant transmitted disease, which is well characterized by the triad of abnormal fragility of the bones, blue sclerae and deafness [8,9,10]. Severe deformities of the lower limbs are frequent.…”

Neurosurgical implications of osteogenesis imperfecta in a child after fall: Case illustration

“…Osteogenesis imperfecta (OI) represents a rare heterogeneous group of inherited disorders characterized by low bone mass and an increase in bone fragility. [123] Different clinical manifestations have been described in these patients, is the most frequent: blue sclerotic, opalescent teeth, hearing loss, long bone deformity and spine, joint hyperextensibility motor development delay and short stature.…”