OSTEOGENESIS FOLLOWING FENESTRATION OF THE VESTIBULAR LABYRINTH OF THE RHESUS MONKEY: A Controlled Experimental Study

XXIII Use of Antibiotics in Stapedectomy: Histopathological Results

“…The adventitia was placed toward the vestibule. These animals were sacrificed at different postoperative periods: 3 weeks, 6 weeks, 8 weeks, 14 weeks, 6 months and approximately one year. The head of the animal was perfused with Heidenhain-Susa solution at the time of sacrifice and the temporal bone sections were made in the usual fashion.…”

XXIII Use of Antibiotics in Stapedectomy: Histopathological Results

“…The adventitia was placed toward the vestibule. These animals were sacrificed at different postoperative periods: 3 weeks, 6 weeks, 8 weeks, 14 weeks, 6 months and approximately one year. The head of the animal was perfused with Heidenhain-Susa solution at the time of sacrifice and the temporal bone sections were made in the usual fashion.…”

Dorothy Wolff: A Pioneer in Otopathology

“…Over the course of her 40-year scientific career, Wolff elucidated mechanisms of osseous change within the temporal bone; she developed a novel animal model to study fixation of the stapes footplate; and she established effective otopathologic techniques to evaluate the auditory system across multiple animal models, including amphibians, birds, felines, and primates. [4][5][6] Her seminal work in otopathology was the prerequisite for subsequent developments in the field of surgical otology, specifically related to the treatment of otosclerosis ( Figure 1). Indeed, if Julius Lempert, MD, is to be remembered as the father of modern otology, Dorothy Wolff, PhD, may well be the lesser-known mother of modern otopathology.…”

“…While their work did not solve issues associated with the fenestration procedure, they did elucidate important aspects of osseous regeneration following damage of the otic capsule that contribute to our current understanding of new bone formation within the middle and inner ear. 6 In the 1950s, with the introduction of stapes mobilization, Wolff recognized the advantages of stapes surgery over fenestration procedures and appropriately shifted her focus to studying surgical outcomes following stapedectomy. Julius Lempert, however, never adopted stapes surgery, and Wolff necessarily moved on from his research laboratory to pursue the next phase of her career.…”

“…While their work did not solve issues associated with the fenestration procedure, they did elucidate important aspects of osseous regeneration following damage of the otic capsule that contribute to our current understanding of new bone formation within the middle and inner ear. 6…”

“…At the peak of her career, she ran the research laboratory at Julius Lempert's Endaural Hospital in New York, where she helped him perfect the single‐stage fenestration procedure for the treatment of otosclerosis. Over the course of her 40‐year scientific career, Wolff elucidated mechanisms of osseous change within the temporal bone; she developed a novel animal model to study fixation of the stapes footplate; and she established effective otopathologic techniques to evaluate the auditory system across multiple animal models, including amphibians, birds, felines, and primates 4‐6 . Her seminal work in otopathology was the prerequisite for subsequent developments in the field of surgical otology, specifically related to the treatment of otosclerosis ( Figure 1 ).…”

XXIII Use of Antibiotics in Stapedectomy: Histopathological Results

“…The adventitia was placed toward the vestibule. These animals were sacrificed at different postoperative periods: 3 weeks, 6 weeks, 8 weeks, 14 weeks, 6 months and approximately one year. The head of the animal was perfused with Heidenhain-Susa solution at the time of sacrifice and the temporal bone sections were made in the usual fashion.…”

Dorothy Wolff: A Pioneer in Otopathology

“…Over the course of her 40-year scientific career, Wolff elucidated mechanisms of osseous change within the temporal bone; she developed a novel animal model to study fixation of the stapes footplate; and she established effective otopathologic techniques to evaluate the auditory system across multiple animal models, including amphibians, birds, felines, and primates. [4][5][6] Her seminal work in otopathology was the prerequisite for subsequent developments in the field of surgical otology, specifically related to the treatment of otosclerosis ( Figure 1). Indeed, if Julius Lempert, MD, is to be remembered as the father of modern otology, Dorothy Wolff, PhD, may well be the lesser-known mother of modern otopathology.…”

“…While their work did not solve issues associated with the fenestration procedure, they did elucidate important aspects of osseous regeneration following damage of the otic capsule that contribute to our current understanding of new bone formation within the middle and inner ear. 6 In the 1950s, with the introduction of stapes mobilization, Wolff recognized the advantages of stapes surgery over fenestration procedures and appropriately shifted her focus to studying surgical outcomes following stapedectomy. Julius Lempert, however, never adopted stapes surgery, and Wolff necessarily moved on from his research laboratory to pursue the next phase of her career.…”

“…While their work did not solve issues associated with the fenestration procedure, they did elucidate important aspects of osseous regeneration following damage of the otic capsule that contribute to our current understanding of new bone formation within the middle and inner ear. 6…”

“…At the peak of her career, she ran the research laboratory at Julius Lempert's Endaural Hospital in New York, where she helped him perfect the single‐stage fenestration procedure for the treatment of otosclerosis. Over the course of her 40‐year scientific career, Wolff elucidated mechanisms of osseous change within the temporal bone; she developed a novel animal model to study fixation of the stapes footplate; and she established effective otopathologic techniques to evaluate the auditory system across multiple animal models, including amphibians, birds, felines, and primates 4‐6 . Her seminal work in otopathology was the prerequisite for subsequent developments in the field of surgical otology, specifically related to the treatment of otosclerosis ( Figure 1 ).…”

XXIII Use of Antibiotics in Stapedectomy: Histopathological Results

“…The adventitia was placed toward the vestibule. These animals were sacrificed at different postoperative periods: 3 weeks, 6 weeks, 8 weeks, 14 weeks, 6 months and approximately one year. The head of the animal was perfused with Heidenhain-Susa solution at the time of sacrifice and the temporal bone sections were made in the usual fashion.…”

Dorothy Wolff: A Pioneer in Otopathology

“…Over the course of her 40-year scientific career, Wolff elucidated mechanisms of osseous change within the temporal bone; she developed a novel animal model to study fixation of the stapes footplate; and she established effective otopathologic techniques to evaluate the auditory system across multiple animal models, including amphibians, birds, felines, and primates. [4][5][6] Her seminal work in otopathology was the prerequisite for subsequent developments in the field of surgical otology, specifically related to the treatment of otosclerosis ( Figure 1). Indeed, if Julius Lempert, MD, is to be remembered as the father of modern otology, Dorothy Wolff, PhD, may well be the lesser-known mother of modern otopathology.…”

“…While their work did not solve issues associated with the fenestration procedure, they did elucidate important aspects of osseous regeneration following damage of the otic capsule that contribute to our current understanding of new bone formation within the middle and inner ear. 6 In the 1950s, with the introduction of stapes mobilization, Wolff recognized the advantages of stapes surgery over fenestration procedures and appropriately shifted her focus to studying surgical outcomes following stapedectomy. Julius Lempert, however, never adopted stapes surgery, and Wolff necessarily moved on from his research laboratory to pursue the next phase of her career.…”

“…While their work did not solve issues associated with the fenestration procedure, they did elucidate important aspects of osseous regeneration following damage of the otic capsule that contribute to our current understanding of new bone formation within the middle and inner ear. 6…”

“…At the peak of her career, she ran the research laboratory at Julius Lempert's Endaural Hospital in New York, where she helped him perfect the single‐stage fenestration procedure for the treatment of otosclerosis. Over the course of her 40‐year scientific career, Wolff elucidated mechanisms of osseous change within the temporal bone; she developed a novel animal model to study fixation of the stapes footplate; and she established effective otopathologic techniques to evaluate the auditory system across multiple animal models, including amphibians, birds, felines, and primates 4‐6 . Her seminal work in otopathology was the prerequisite for subsequent developments in the field of surgical otology, specifically related to the treatment of otosclerosis ( Figure 1 ).…”