Ossifying Parotid Carcinoma Ex Pleomorphic Adenoma

Ossifying Parotid Carcinoma ex Pleomorphic Adenoma

“…Unfortunately, due to the coexistence of multiple tissue types, CXPA imaging findings can be nonspecific and poorly distinguished from other benign or malignant salivary gland tumors. For example, PA and CXPA may appear similarly on CT, with calcified regions of cartilaginous elements seen frequently in both [ 4 ]. Kato and colleagues recently have suggested using diffusion-weighted MRI to distinguish benign and malignant tissue in CXPA [ 5 ].…”

“…In the head and neck, the tongue is the most common site, while, in contrast, parotid tumor calcification is rare. When present, however, ossification in parotid masses is highly suggestive of pleomorphic adenoma [ 4 , 6 ]. PAs commonly contain mucoid, chondromyxoid, or hyalinized mesenchymal-like elements, but reports of extensive stromal ossification are limited [ 6 – 8 ].…”

“…Reports of ossification of CXPA are extremely rare. Spencer et al reported the first ossifying CXPA identified on CT, noting that punctate calcifications in both benign and malignant PAs had been observed previously, but without bone formation [ 4 ]. They describe a large parotid carcinoma with a core of well-formed, trabecular bone on CT, revealing its origin as a PA, but without any concealment of the carcinomatous portion of the mass.…”

“…They describe a large parotid carcinoma with a core of well-formed, trabecular bone on CT, revealing its origin as a PA, but without any concealment of the carcinomatous portion of the mass. They also recommend CT over MRI as a modality for imaging PA, noting that MR is less reliable in assessing necrotic tumor foci, a potential marker of malignant change, and in identifying calcifications or tumoral bone [ 4 ]. In contrast, our case features a benign appearance on CT.…”

Ossifying Parotid Carcinoma ex Pleomorphic Adenoma

“…Unfortunately, due to the coexistence of multiple tissue types, CXPA imaging findings can be nonspecific and poorly distinguished from other benign or malignant salivary gland tumors. For example, PA and CXPA may appear similarly on CT, with calcified regions of cartilaginous elements seen frequently in both [ 4 ]. Kato and colleagues recently have suggested using diffusion-weighted MRI to distinguish benign and malignant tissue in CXPA [ 5 ].…”

“…In the head and neck, the tongue is the most common site, while, in contrast, parotid tumor calcification is rare. When present, however, ossification in parotid masses is highly suggestive of pleomorphic adenoma [ 4 , 6 ]. PAs commonly contain mucoid, chondromyxoid, or hyalinized mesenchymal-like elements, but reports of extensive stromal ossification are limited [ 6 – 8 ].…”

“…Reports of ossification of CXPA are extremely rare. Spencer et al reported the first ossifying CXPA identified on CT, noting that punctate calcifications in both benign and malignant PAs had been observed previously, but without bone formation [ 4 ]. They describe a large parotid carcinoma with a core of well-formed, trabecular bone on CT, revealing its origin as a PA, but without any concealment of the carcinomatous portion of the mass.…”

“…They describe a large parotid carcinoma with a core of well-formed, trabecular bone on CT, revealing its origin as a PA, but without any concealment of the carcinomatous portion of the mass. They also recommend CT over MRI as a modality for imaging PA, noting that MR is less reliable in assessing necrotic tumor foci, a potential marker of malignant change, and in identifying calcifications or tumoral bone [ 4 ]. In contrast, our case features a benign appearance on CT.…”

Schwannoma-like pleomorphic adenoma of the parotid

“…In some cases an important chondroid matrix was present with the formation of enchondral ossification at the borders. 9 Others described the formation of osteoid indicating a possible direct differentiation from myoepithelial cells 10,11 Osseous metaplasia can also be found in carcinoma ex pleomorphic adenoma 12,13 and mixed tumour of the skin. 14,15 …”

Ossifying Parotid Carcinoma ex Pleomorphic Adenoma

“…Unfortunately, due to the coexistence of multiple tissue types, CXPA imaging findings can be nonspecific and poorly distinguished from other benign or malignant salivary gland tumors. For example, PA and CXPA may appear similarly on CT, with calcified regions of cartilaginous elements seen frequently in both [ 4 ]. Kato and colleagues recently have suggested using diffusion-weighted MRI to distinguish benign and malignant tissue in CXPA [ 5 ].…”

“…In the head and neck, the tongue is the most common site, while, in contrast, parotid tumor calcification is rare. When present, however, ossification in parotid masses is highly suggestive of pleomorphic adenoma [ 4 , 6 ]. PAs commonly contain mucoid, chondromyxoid, or hyalinized mesenchymal-like elements, but reports of extensive stromal ossification are limited [ 6 – 8 ].…”

“…Reports of ossification of CXPA are extremely rare. Spencer et al reported the first ossifying CXPA identified on CT, noting that punctate calcifications in both benign and malignant PAs had been observed previously, but without bone formation [ 4 ]. They describe a large parotid carcinoma with a core of well-formed, trabecular bone on CT, revealing its origin as a PA, but without any concealment of the carcinomatous portion of the mass.…”

“…They describe a large parotid carcinoma with a core of well-formed, trabecular bone on CT, revealing its origin as a PA, but without any concealment of the carcinomatous portion of the mass. They also recommend CT over MRI as a modality for imaging PA, noting that MR is less reliable in assessing necrotic tumor foci, a potential marker of malignant change, and in identifying calcifications or tumoral bone [ 4 ]. In contrast, our case features a benign appearance on CT.…”

Schwannoma-like pleomorphic adenoma of the parotid

“…In some cases an important chondroid matrix was present with the formation of enchondral ossification at the borders. 9 Others described the formation of osteoid indicating a possible direct differentiation from myoepithelial cells 10,11 Osseous metaplasia can also be found in carcinoma ex pleomorphic adenoma 12,13 and mixed tumour of the skin. 14,15 …”

Ossifying Parotid Carcinoma ex Pleomorphic Adenoma

“…Unfortunately, due to the coexistence of multiple tissue types, CXPA imaging findings can be nonspecific and poorly distinguished from other benign or malignant salivary gland tumors. For example, PA and CXPA may appear similarly on CT, with calcified regions of cartilaginous elements seen frequently in both [ 4 ]. Kato and colleagues recently have suggested using diffusion-weighted MRI to distinguish benign and malignant tissue in CXPA [ 5 ].…”

“…In the head and neck, the tongue is the most common site, while, in contrast, parotid tumor calcification is rare. When present, however, ossification in parotid masses is highly suggestive of pleomorphic adenoma [ 4 , 6 ]. PAs commonly contain mucoid, chondromyxoid, or hyalinized mesenchymal-like elements, but reports of extensive stromal ossification are limited [ 6 – 8 ].…”

“…Reports of ossification of CXPA are extremely rare. Spencer et al reported the first ossifying CXPA identified on CT, noting that punctate calcifications in both benign and malignant PAs had been observed previously, but without bone formation [ 4 ]. They describe a large parotid carcinoma with a core of well-formed, trabecular bone on CT, revealing its origin as a PA, but without any concealment of the carcinomatous portion of the mass.…”

“…They describe a large parotid carcinoma with a core of well-formed, trabecular bone on CT, revealing its origin as a PA, but without any concealment of the carcinomatous portion of the mass. They also recommend CT over MRI as a modality for imaging PA, noting that MR is less reliable in assessing necrotic tumor foci, a potential marker of malignant change, and in identifying calcifications or tumoral bone [ 4 ]. In contrast, our case features a benign appearance on CT.…”

Schwannoma-like pleomorphic adenoma of the parotid

“…In some cases an important chondroid matrix was present with the formation of enchondral ossification at the borders. 9 Others described the formation of osteoid indicating a possible direct differentiation from myoepithelial cells 10,11 Osseous metaplasia can also be found in carcinoma ex pleomorphic adenoma 12,13 and mixed tumour of the skin. 14,15 …”