Osmoviscoelastic finite element model of the intervertebral disc

Schroeder, Y.; Wilson, W.; Huyghe, Jmrj Jacques; Baaijens, F.P.T.

doi:10.1007/s00586-006-0110-3

Cited by 79 publications

(64 citation statements)

References 57 publications

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“…The simulation of intervertebral discs is a major challenge, and therefore, the geometry of the disc has been inevitably simplified in most of the previous studies. For example, the disc structure was assumed to be axisymmetric [22,23] or symmetrical in the sagittal [24] or sagittal and transverse planes [23]. Further, the superior and inferior surfaces of the disc are also assumed to be flat, although some segmental models do consider a more realistic curvature [25].…”

Section: Discussionmentioning

confidence: 99%

Establishment and Validation of a Computed Tomography–Based Finite Element Model of Lumbar3-5 Vertebrae

Xia¹,

Zhang²,

Chen³

et al. 2018

dtcse

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Objective: To describe a rapid method for establishing a finite element model of the lumbar vertebrae by using computed tomography (CT) images Methods: CT images of the L3-L5 vertebrae of a 75-year-old man were acquired and used to establish a finite element model using the Minics 10.01 and Hypermesh 11.0 softwares. Soft tissues, such as the intervertebral discs and ligaments, were manually meshed. The model thus generated was subjected to a vertical force of 400 N and a torsion force of 10 N·m to simulate the conditions of the human spine in the standing position. Results: The CT-based finite element model of the lumbar vertebrae was successfully established, accurately reflecting the anatomy of both vertebrae and attached soft tissues. The biomechanical response of the model to the external testing forces was within the accepted normal ranges. Conclusion: We constructed a feasible and accurate CT-based finite element model of the lumbar vertebrae with manually meshing of the soft tissue data. This model showed good consistency with in vitro experimental data. Thus, our method appeared to be useful in the construction of a finite element model of the spine.

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Section: Discussionmentioning

confidence: 99%

Establishment and Validation of a Computed Tomography–Based Finite Element Model of Lumbar3-5 Vertebrae

Xia¹,

Zhang²,

Chen³

et al. 2018

dtcse

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“…The 3D FE mesh was based on a simplified geometry of a human lumbar disc (L4/L5; Schroeder et al 2006). Because symmetry about the transversal and sagittal plane was assumed, the mesh was reduced to 1/4 of the size of the disc ( Fig.…”

Section: Finite Element Modelmentioning

confidence: 99%

“…This is of special interest, as variation in the experimental data entails a large variability in the material properties describing the disc tissue behavior (Jones and Wilcox 2008). This paper presents a novel FE model at a wholeorgan level; the 3D OVED model describes the overall disc behavior as a function of annulus and nucleus tissue biochemical composition, organization and the specific material properties of each of these constituents (Schroeder et al 2006;Schroeder et al 2008). The description of the 3D collagen network in the 3D OVED model is (Table 1) enhanced to account for smaller fibril structures.…”

Section: Introductionmentioning

confidence: 99%

A biochemical/biophysical 3D FE intervertebral disc model

Schroeder

Huyghe

Donkelaar

et al. 2010

Biomech Model Mechanobiol

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Present research focuses on different strategies to preserve the degenerated disc. To assure long-term success of novel approaches, favorable mechanical conditions in the disc tissue are essential. To evaluate these, a model is required that can determine internal mechanical conditions which cannot be directly measured as a function of assessable biophysical characteristics. Therefore, the objective is to evaluate if constitutive and material laws acquired on isolated samples of nucleus and annulus tissue can be used directly in a wholeorgan 3D FE model to describe intervertebral disc behavior. The 3D osmo-poro-visco-hyper-elastic disc (OVED) model describes disc behavior as a function of annulus and nucleus tissue biochemical composition, organization and specific constituent properties. The description of the 3D collagen network was enhanced to account for smaller fibril structures. Tissue mechanical behavior tests on isolated nucleus and annulus samples were simulated with models incorporating tissue composition to calculate the constituent parameter values. The obtained constitutive laws were incorporated into the whole-organ model. The overall behavior and disc properties of the model were corroborated against in vitro creep experiments of human L4/L5 discs. The OVED model simulated isolated tissue experiments on confined compression and uniaxial tensile test and whole-organ disc behavior. This was possible, provided that secondary fiber structures were accounted for. The fair agreement (radial bulge, axial creep deformation and intradiscal pressure) between model and experiment was obtained using constitutive properties that are the same for annulus and nucleus. Both tissue models differed in the 3D OVED model only by composition. The composition-based modeling presents the advantage of reducing the numbers of material parameters to a minimum and to use tissue composition directly as input. Hence, this approach provides the possibility to describe internal mechanical conditions of the disc as a function of assessable biophysical characteristics.

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“…Though, it is estimated that 20% of the water is absorbed by the collagen network. Different modelling strategies have been proposed to grasp its coupled electro-chemo-mechanical properties (Huyghe 1999, Iatridis et al 2003, van Loon et al 2003, Schroeder et al 2006 Selected paper presented at the IUTAM Symposium on Swelling and Shrinking of Porous Materials: From Colloid Science to Poromechanics -August 06-10 2007, LNCC/MCT. E-mail: j.m.r.huyghe@tue.nl Schroeder et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Biaxial testing of canine annulus fibrosus tissue under changing salt concentrations

Huyghe

2010

An. Acad. Bras. Ciênc.

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The in vivo mechanics of the annulus fibrosus of the intervertebral disc is one of biaxial rather than uniaxial loading. The material properties of the annulus are intimately linked to the osmolarity in the tissue. This paper presents biaxial relaxation experiments of canine annulus fibrosus tissue under stepwise changes of external salt concentration. The force tracings show that stresses are strongly dependent on time, salt concentration and orientation. The force tracing signature of a response to a change in strain, is one of a jump in stress that relaxes partly as the new strain is maintained. The force tracing signature of a stepwise change in salt concentration is a progressive monotonous change in stress towards a new equilibrium value. Although the number of samples does not allow any definitive quantitative conclusions, the trends may shed light on the complex interaction among the directionality of forces, strains and fiber orientation on one hand, and on the other hand, the osmolarity of the tissue. The dual response to a change in strain is understood as an immediate response before fluid flows in or out of the tissue, followed by a progressive readjustment of the fluid content in time because of the gradient in fluid chemical potential between the tissue and the surrounding solution.

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Osmoviscoelastic finite element model of the intervertebral disc

Cited by 79 publications

References 57 publications

Establishment and Validation of a Computed Tomography–Based Finite Element Model of Lumbar3-5 Vertebrae

Establishment and Validation of a Computed Tomography–Based Finite Element Model of Lumbar3-5 Vertebrae

A biochemical/biophysical 3D FE intervertebral disc model

Biaxial testing of canine annulus fibrosus tissue under changing salt concentrations

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