Osler-Weber-Rendu syndrome during pregnancy

Abstract

Osler-Weber-Rendu syndrome is a very rare systemic fibrovascular dysplasia. Rupture of angiomas can cause haemorrhages, which sometimes can be severe with difficult bleeding control. The main manifestation is recurrent epistaxis. Treatment of this disorder is symptomatic. During pregnancy, there may be an increased risk of complications. We describe a case of a pregnant woman with Osler-Weber-Rendu syndrome. Besides frequent epistaxis and microcytic hypochromic anaemia that resolved with oral iron treatment, she had a normal pregnancy, vaginal delivery and puerperium without complications.

Planning Pregnancy and Birth in Women with Inherited Bleeding Disorders

“…46 Prophylaxis with VWF concentrates during pregnancy in type 3 VWD has been reported only in a few case studies. 47 48 Conversely, a case–control study by the Healthcare Cost and Utilization Project of the Agency for Healthcare Research and Quality utilizing the United States Nationwide Inpatient Sample noted antepartum bleeding in 280 of 4,067 (6.8%) women with VWD; 10 times more frequent than in unaffected controls (odds ratio [OR]: 10.2; 95% confidence interval [CI], 7.1–14.6) but no increase in the risk of placental abruption. 49…”

Congenital vascular malformations

“…Auch wenn das Verständnis der Erkrankung und die Kenntnis von Komplikationen in der Schwangerschaft in den letzten Jahren zugenommen haben, ist die Datenlage zu Schwangerschaften bei M. Osler-Weber-Rendu spärlich (35)(36)(37)(38)(39).…”

Post-Partum Hemorrhage (PPH) as Implicated by Osler-Weber-Rendu Syndrome

“…A family history of HHT (i.e., first-degree relative such as brother, sister, parent, or child who meets these same criteria for definite HHT or has been genetically diagnosed) [ 3 - 4 ]. The prognosis is generally good and the telangiectasias typically manifest themselves as pseudopigmented lesions of the lips and recurrent epistaxis, but may potentially pose an increased challenge in surgical bleeding management and wound repair in an otherwise asymptomatic individual [ 5 - 7 ]. All this considered, the typical incidence of HHT is about 1 in 10,000 [ 7 ].…”