Abstract:The mammalian circadian clock plays a crucial role in regulating the 24-hour physiological and behavioral processes. This work presents an improved model for the mammalian circadian clock by integrating physiologically plausible modifications into the Kim-Forger model, and investigates the oscillatory dynamics of the mammalian circadian clock induced by the core delayed negative feedback loop using bifurcation theory. The modifications involve introducing time delays in PER protein transcription, translation, … Show more
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