“…24 Leukocyte filtration has been shown to be effective in treating endothelial injury after both acute coronary occlusion 26 and HTx. 12,13,27,28 In addition, prevention (rather than treatment) of endothelial stunning may be possible, because some investigators have found that delivery of the natural nitric oxide precursor, L-arginine, limits endothelial and myocyte damage, even without white blood cell depletion. 29 -31 The relation between myocyte and endothelial injury and stunning is underscored by reports that, in cardiac transplantation, myocardial protection may be important for both early graft failure and non-immunologic vascular failure of the transplanted heart, leading to allograft vascular disease.…”