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“…The combined clinical wisdom of this group of experts ( n  = 13) proclaimed that a 20-mmHg systolic and/or a 10-mmHg diastolic decline from lying to standing within 3 min of standing should be the standard. The 1996 criteria were primarily based on a study of 92 male and female normal subjects aged 17–61 years [24, 25], as epidemiological data were unavailable at that time. A later study by Fedorowski et al in a population-based cohort of 924 subjects confirmed that the older 20/10-mmHg standard for the definition of OH was an excellent cutoff for normotensive persons [5].…”
Section: Discussionmentioning
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“…The combined clinical wisdom of this group of experts ( n  = 13) proclaimed that a 20-mmHg systolic and/or a 10-mmHg diastolic decline from lying to standing within 3 min of standing should be the standard. The 1996 criteria were primarily based on a study of 92 male and female normal subjects aged 17–61 years [24, 25], as epidemiological data were unavailable at that time. A later study by Fedorowski et al in a population-based cohort of 924 subjects confirmed that the older 20/10-mmHg standard for the definition of OH was an excellent cutoff for normotensive persons [5].…”
Section: Discussionmentioning
“…9 Much of the subsequent history of the concept of OI is discussed by Streeten. 10, 11 Streeten proposed a classification of milder orthostatic disorders roughly calibrated with the severity of the impairment. This patient population is heterogeneous [12][13][14][15][16][17][18][19][20][21] and has been referred to by many names, as follow:…”
Section: Diversity Of Autonomic Dysregulationmentioning
“…Simple activities such as eating, showering, or low-intensity exercise may profoundly exacerbate these symptoms and may significantly impair even the most rudimentary activities of daily living. [6][7][8][9] This chronic orthostatic intolerance is a disorder that disproportionately (3-4 times more frequent) affects young women. The illness may develop subacutely and is often preceded by a viral-like illness.…”
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