Orthobunyaviruses (Peribunyaviridae)

Evans, Alyssa B.; Winkler, Clayton W.; Peterson, Karin E.

doi:10.1016/b978-0-12-809633-8.21542-2

Cited by 4 publications

(6 citation statements)

References 31 publications

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“…The genus Orthobunyavirus belonging to the family Peribunyaviridae (order Bunyavirales ) contains numerous mosquito-borne bunyaviruses [ 7 ]. So far, orthobunyaviruses have been detected in various of mosquito species, including Ochlerotatus spp., Culex spp.…”

Section: Introductionmentioning

confidence: 99%

Vector competence and immune response of Aedes aegypti for Ebinur Lake virus, a newly classified mosquito-borne orthobunyavirus

Yang

Wang²,

Huang³

et al. 2022

PLoS Negl Trop Dis

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The global impact of mosquito-borne diseases has increased significantly over recent decades. Ebinur Lake virus (EBIV), a newly classified orthobunyavirus, is reported to be highly pathogenic in adult mice. The evaluation of vector competence is essential for predicting the arbovirus transmission risk. Here, Aedes aegypti was applied to evaluate EBIV infection and dissemination in mosquitos. Our experiments indicated that Ae. aegypti had the possibility to spread EBIV (with a transmission rate of up to 11.8% at 14 days post-infection) through biting, with the highest viral dose in a single mosquito’s saliva reaching 6.3 plaque-forming units. The highest infection, dissemination and ovary infection rates were 70%, 42.9%, and 29.4%, respectively. The high viral infection rates in Ae. aegypti ovaries imply the possibility of EBIV vertical transmission. Ae. aegypti was highly susceptible to intrathoracic infection and the saliva-positive rate reached 90% at 10 days post-infection. Transcriptomic analysis revealed Toll and Imd signaling pathways were implicated in the mosquito’s defensive response to EBIV infection. Defensin C and chitinase 10 were continuously downregulated in mosquitoes infected via intrathoracic inoculation of EBIV. Comprehensive analysis of the vector competence of Ae. aegypti for EBIV in laboratory has indicated the potential risk of EBIV transmission through mosquitoes. Moreover, our findings support a complex interplay between EBIV and the immune system of mosquito, which could affect its vector competence.

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Section: Introductionmentioning

confidence: 99%

Vector competence and immune response of Aedes aegypti for Ebinur Lake virus, a newly classified mosquito-borne orthobunyavirus

Yang

Wang²,

Huang³

et al. 2022

PLoS Negl Trop Dis

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“…Records of SSHV in northern Asia and northern Europe ( Traavik et al 1978 , Mitchell et al 1993 , Lundström 1999 , Putkuri et al 2014 , 2016 ) are probably Chatanga virus or Tanhyna virus, mosquito-borne California serogroup viruses closely related to SSHV, and causative agents of human infection and disease ( Putkuri et al 2016 , Hughes et al 2017 , Evans and Peterson 2019 , and Evans et al 2021 ). A serosurvey of small mammals including shrews (genus Sorex ) in western Siberia documented high seropositivity rates to SSHV (80.4% of the 184 individuals); however, only a single putative isolate of SSHV was obtained in the same study from a single Aedes euedes Howard, Dyar, and Knab mosquito.…”

Section: Distributionmentioning

confidence: 99%

Snowshoe hare virus: discovery, distribution, vector and host associations, and medical significance

Walker,

Yuill

2023

Journal of Medical Entomology

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Snowshoe hare virus (SSHV), within the California serogroup of the genus Orthobunyavirus, family Peribunyaviridae, was first isolated from a snowshoe hare (Lepus americanus) in Montana, United States, in 1959. The virus, closely related to LaCrosse virus (LACV) and Chatanga virus (CHATV), occurs across Canada and the northern latitudes of the United States, primarily in the northern tier of states bordering Canada. Reports of SSHV in northern Europe and Asia are probably the closely related to CHATV, or the less closely related Tahyna virus. Vertebrate associations include snowshoe hares and ground squirrels, demonstrated by field isolation of virus from wild-caught animals, seroconversion of snowshoe hares, seroconversion of sentinel rabbits, isolation of virus from sentinel rabbits, and experimental infections demonstrating viremia. Isolations of virus from field populations of mosquitoes include primarily univoltine and boreal mosquitoes of the genus Aedes, Culiseta impatiens and Culiseta inornata; and, rarely, certain multivoltine floodwater Aedes species. Experimental transmission studies in mosquitoes show infection in and transmission by boreal Aedes and Culiseta inornata. Isolation of SSHV from larval Aedes on three occasions, and experimentation in Culiseta inornata, reveal transovarial transmission of the virus in mosquitoes. Serosurveys reveal exposure to SSHV in human and domestic animals, with rates of seropositivity commonly high in some settings in Alaska and Canada, but disease in humans or horses has rarely been reported, only in Canada.

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“…The family Peribunyaviridae , genus Orthobunyavirus , contains three-segmented, negative-stranded RNA viruses transmitted exclusively by arthropods [ 3 ]. So far, nearly 200 viruses of the genus Orthobunyavirus have been identified, and they are grouped into 20 serogroups [ 4 ]. Multiple viruses belonging to the Simbu and Bunyawera serogroups have been found in various mosquito species, including Culex spp., Aedes spp., and Anopheles spp.…”

Section: Introductionmentioning

confidence: 99%

“…Oya virus (OYAV) and Ebinur Lake virus (EBIV) belong to the Orthobunyavirus genus [ 4 ]. Oya virus and Cat Que virus (CQV) are classified under the same virus species, Orthobunyavirus catqueense [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluating the mosquito vector range for two orthobunyaviruses: Oya virus and Ebinur Lake virus

Liu,

Wang,

Wang

et al. 2024

Parasites Vectors

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Background Mosquito-borne viruses cause various infectious diseases in humans and animals. Oya virus (OYAV) and Ebinur Lake virus (EBIV), belonging to the genus Orthobunyavirus within the family Peribunyaviridae, are recognized as neglected viruses with the potential to pose threats to animal or public health. The evaluation of vector competence is essential for predicting the arbovirus transmission risk. Methods To investigate the range of mosquito vectors for OYAV (strain SZC50) and EBIV (strain Cu20-XJ), the susceptibility of four mosquito species (Culex pipiens pallens, Cx. quinquefasciatus, Aedes albopictus, and Ae. aegypti) was measured through artificial oral infection. Then, mosquito species with a high infection rate (IR) were chosen to further evaluate the dissemination rate (DR), transmission rate (TR), and transmission efficiency. The viral RNA in each mosquito sample was determined by RT-qPCR. Results The results revealed that for OYAV, Cx. pipiens pallens had the highest IR (up to 40.0%) among the four species, but the DR and TR were 4.8% and 0.0%, respectively. For EBIV, Cx. pipiens pallens and Cx. quinquefasciatus had higher IR compared to Ae. albopictus (1.7%). However, the EBIV RNA and infectious virus were detected in Cx. pipiens pallens, with a TR of up to 15.4% and a transmission efficiency of 3.3%. Conclusions The findings indicate that Cx. pipiens pallens was susceptible to OYAV but had an extremely low risk of transmitting the virus. Culex pipiens pallens and Cx. quinquefasciatus were susceptible to EBIV, and Cx. pipiens pallens had a higher transmission risk to EBIV than Cx. quinquefasciatus. Graphical Abstract

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Orthobunyaviruses (Peribunyaviridae)

Cited by 4 publications

References 31 publications

Vector competence and immune response of Aedes aegypti for Ebinur Lake virus, a newly classified mosquito-borne orthobunyavirus

Vector competence and immune response of Aedes aegypti for Ebinur Lake virus, a newly classified mosquito-borne orthobunyavirus

Snowshoe hare virus: discovery, distribution, vector and host associations, and medical significance

Evaluating the mosquito vector range for two orthobunyaviruses: Oya virus and Ebinur Lake virus

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