Orosomucoid as prognosis factor associated with inflammation in acute or nutritional status in chronic heart failure

Agra, Rosa M.; Román, Alfonso Varela; González‐Ferreiro, Rocío; Viñuela, Juan E.; Castro-Pais, Ana; Fernández-Trasancos, Ángel; Díaz‐Rodriguez, Esther; Álvarez, Ezequiel; Carreira, Marcos C.; Casanueva, Felipe F.; González-Juanatey, José Ramón; Eiras, Sonia

doi:10.1016/j.ijcard.2016.11.134

Cited by 14 publications

(20 citation statements)

References 35 publications

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“…These authors found a positive correlation between the production of monocyte tumor necrosis factor (TNF) α and plasma levels of CRP with CONUT score. This myocardial imbalance might alter levels of circulating adipocytokines, including ghrelin, leptin, growth hormone and, more recently, orosomucoid [ 37 ]. This situation might contribute to the wasting process by altering appetite and energy expenditure [ [37] , [38] , [39] ].…”

Section: Discussionmentioning

confidence: 99%

“…This myocardial imbalance might alter levels of circulating adipocytokines, including ghrelin, leptin, growth hormone and, more recently, orosomucoid [ 37 ]. This situation might contribute to the wasting process by altering appetite and energy expenditure [ [37] , [38] , [39] ]. The derangement of these hormone systems, potentially triggered by the effects of proinflammatory cytokines may be responsible for the development of satiety without adequate food intake and the promotion of other deleterious mechanisms in HF.…”

Section: Discussionmentioning

confidence: 99%

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Prognostic value of nutrition status in the response of cardiac resynchronization therapy

Álvarez‐Álvarez

Seara

Rodríguez‐Mañero

et al. 2018

Indian Pacing and Electrophysiology Journal

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BackgroundCardiac resynchronization therapy (CRT) is indicated in symptomatic heart failure (HF) patients after achieving optimal medical therapy. However, there are still a large percentage of patients who do not respond to CRT. Malnutrition is a frequent comorbidity in patients with HF, and it is associated with a poorer prognosis. Here, we evaluate the nutritional status of patients assessed by Controlling Nutritional Status (CONUT) score and its association with structural remodeling and cardiovascular events.MethodsWe investigated the effect of CONUT on HF/death in 302 consecutive patients with a CRT device implanted between 2005 and 2015 in a single tertiary center. We categorized the patients into three groups: normal nutritional status (CONUT 0–1), mild malnutrition (CONUT 2–4) and moderate-severe malnutrition (CONUT ≥ 5). Changes in nutritional status were assessed in patients with mild-to-severe malnutrition prior to CRT.ResultsOne hundred and forty-eight patients exhibited normal nutritional status (49.0%), 99 patients exhibited mild malnutrition (32.8%) and 55 patients exhibited moderate-severe malnutrition (18.2%). CONUT scores of at least 2 were associated with higher risk of HF/death compared with CONUT 0–1. Significant left ventricular (LV) reverse remodeling was noted in patients with better nutritional status. In addition, those malnutrition patients at baseline that improved nutritional state exhibited fewer HF/death events at follow-up.ConclusionCONUT score prior to CRT was an independent risk factor of death/HF and was correlated with LV reverse remodeling. Improvements in CONUT score during long-term follow-up were associated with a reduction in the rate of HF/death.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prognostic value of nutrition status in the response of cardiac resynchronization therapy

Álvarez‐Álvarez

Seara

Rodríguez‐Mañero

et al. 2018

Indian Pacing and Electrophysiology Journal

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“…Blood samples were obtained at discharge as we previously described 26 and were centrifuged at 1800 xg for 15 minutes. Isolated plasma was stored at -80 ºC until be used.…”

Section: Methodsmentioning

confidence: 99%

Nutrients restriction upregulates adiponectin in epicardial or subcutaneous adipose tissue: impact in de novo heart failure patients

Agra¹,

Fernández-Trasancos²,

Díaz‐Rodriguez³

et al. 2018

Int. J. Med. Sci.

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Background: Hyperadiponectinemia is an indicator of worse outcomes in advanced heart failure (HF), its role in de novo HF is less clear.Objective: Because this protein is a hormone with starvation properties, we wanted to know its association with nutritional state and its regulator factors in de novo HF.Methods: Adiponectin circulating levels were determined by ELISA at discharge in patients admitted for de novo HF (n=74). Nutritional status was determined by CONUT score. Univariate and multivariate Cox regression analyses were employed to calculate the estimated hazard ratio (HR) with 95% confidence interval (CI) for death or all-cause readmission. Stromal vascular cells (SVC) of EAT and subcutaneous adipose tissue (SAT) from patients (n=5) underwent heart surgery were induced to adipogenesis for 18 days. Then, cells were cultured with complete or starved medium for 8 hours. At the end, adiponectin expression levels were analysed by real time polymerase chain reaction.Results: Patients were grouped regarding nutritional status. There was a strong association between high adiponectin levels and failing nutritional status. Those patients with worse nutritional state had the highest adiponectin and proBNP levels at discharge (p<0.01). Both proteins were slightly correlated (p<0.05). However, only high adiponectin levels were independently associated with death or all-cause readmission. Nutrients starvation upregulated adiponectin expression levels in adipogenesis-induced SVC from EAT or SAT.Conclusions: Worse nutritional state in de novo HF patients is associated with higher adiponectin plasma levels. Their levels were upregulated in adipose cells after being nutrients-starved. These results may help us to understand the adiponectin paradox in HF.

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“…Although the underlying molecular mechanism has not yet been elucidated, there are emerging evidences from proteomic studies that both the urinary and serum Orm1 may serve as predictors of therapeutic response and diagnostic and prognostic biomarkers for inflammatory diseases such as chronic heart failure ( Agra et al, 2017 , Yin et al, 2004 ) and cancers such as bladder cancer ( Li et al, 2016 ), lung squamous cell carcinoma ( Ayyub et al, 2016 ), breast cancer ( Alexander et al, 2004 ) as well as HCC ( Falleti et al, 1993 ). There is a well-recognized link between tissue regeneration and tumorigenesis, which share common molecular pathways in controlling cell growth ( Charni et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

“…In addition, it is known as an acute phase protein, which is expressed in response to stressful conditions such as tissue injury, inflammation, or infection ( Lee et al, 2010 ). There are emerging evidences from proteomic studies that both the urinary and serum Orm1 may serve as predictors of therapeutic response and diagnostic and prognostic biomarkers for inflammatory diseases such as chronic heart failure ( Agra et al, 2017 ) and cancers such as bladder cancer ( Li et al, 2016 ), lung squamous cell carcinoma ( Ayyub et al, 2016 ), breast cancer ( Alexander et al, 2004 ) as well as hepatocellular carcinoma (HCC) ( Falleti et al, 1993 ). However, the specific function of Orm1 under stresses has not yet been fully elucidated.…”

Section: Introductionmentioning

confidence: 99%

Transcriptome Analysis Uncovers a Growth-Promoting Activity of Orosomucoid-1 on Hepatocytes

et al. 2017

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The acute phase protein orosomucoid-1 (Orm1) is mainly expressed by hepatocytes (HPCs) under stress conditions. However, its specific function is not fully understood. Here, we report a role of Orm1 as an executer of HPC proliferation. Increases in serum levels of Orm1 were observed in patients after surgical resection for liver cancer and in mice undergone partial hepatectomy (PH). Transcriptome study showed that Orm1 became the most abundant in HPCs isolated from regenerating mouse liver tissues after PH. Both in vitro and in vivo siRNA-induced knockdown of Orm1 suppressed proliferation of mouse regenerating HPCs and human hepatic cells. Microarray analysis in regenerating mouse livers revealed that the signaling pathways controlling chromatin replication, especially the minichromosome maintenance protein complex genes were uniformly down-regulated following Orm1 knockdown. These data suggest that Orm1 is induced in response to hepatic injury and executes liver regeneration by activating cell cycle progression in HPCs.

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Orosomucoid as prognosis factor associated with inflammation in acute or nutritional status in chronic heart failure

Cited by 14 publications

References 35 publications

Prognostic value of nutrition status in the response of cardiac resynchronization therapy

Prognostic value of nutrition status in the response of cardiac resynchronization therapy

Nutrients restriction upregulates adiponectin in epicardial or subcutaneous adipose tissue: impact in de novo heart failure patients

Transcriptome Analysis Uncovers a Growth-Promoting Activity of Orosomucoid-1 on Hepatocytes

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