Oromucosal immunomodulation as clinical spectrum mitigating factor in SARS‐CoV‐2 infection

Rodriguez-Argente, F.; Alba-Domínguez, María; Ortiz‐Muñoz, Elena; Ortega‐González, Ángel

doi:10.1111/sji.12972

Cited by 7 publications

(9 citation statements)

References 21 publications

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“…Thus, recognition of SARS-CoV-2 by heterologous antibodies in BIM could cause complement fixation of the immune complexes, triggering activation of any of its pathways. This would generate specific responses of neutralization, cytolysis, chemotaxis, opsonization, and others ( 55 ), as well as the activation of other immune mechanisms that would benefit immune action, such as the production of IL-10, IFN-β ( 56 ), or CD27 cells ( 57 ) (which would involve the activation, proliferation, and differentiation of B lymphocytes) or even activation of immunoglobulin class switching ( 58 ). The complexity of the cytokine network in humans makes immunomodulation essential in the control of severe COVID-19 and could be achieved by the presence of specific immunoglobulins in the GALT and gut lumen.…”

Section: Discussionmentioning

confidence: 99%

Bovine Coronavirus Immune Milk Against COVID-19

et al. 2021

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After a year of evolution of the SARS-CoV-2 epidemic, there is still no specific effective treatment for the disease. Although the majority of infected people experience mild disease, some patients develop a serious disease, especially when other pathologies concur. For this reason, it would be very convenient to find pharmacological and immunological mechanisms that help control SARS-CoV-2 infection. Since the COVID-19 and BCoV viruses are very close phylogenetically, different studies demonstrate the existence of cross-immunity as they retain shared epitopes in their structure. As a possible control measure against COVID-19, we propose the use of cow’s milk immune to BCoV. Thus, the antigenic recognition of some highly conserved structures of viral proteins, particularly M and S2, by anti-BCoV antibodies present in milk would cause a total or partial inactivation of SARS-COV-2 (acting as a particular vaccine) and be addressed more easily by GALT’s highly specialized antigen-presenting cells, thus helping the specific immune response.

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Section: Discussionmentioning

confidence: 99%

Bovine Coronavirus Immune Milk Against COVID-19

et al. 2021

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“…We are not alone, others have pointed to a strong correlation between high iodine diets and significantly lower death rates from COVID‐19 infection in Japan 3,4 . This is a follow‐up comment to the Discussion Forum paper presented by Rodríguez‐Argente et al 5 in this journal where they point to the importance of encouraging innate immunity in the oral and upper respiratory tracts to prevent COVID‐19 infection.…”

Section: Country Population (M) % Vaccinated (≥1 Dose) Infections (%)...mentioning

confidence: 99%

High dietary iodine intake may contribute to the low death rate from COVID‐19 infection in Japan with activation by the lactoperoxidase system

Smith¹,

Sharma

Singh

2023

Scand J Immunol

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We draw the attention of readers and governments to the death rate from coronavirus disease 2019 in Japan, continuing as a fraction of that experienced by many other developed nations. We think this is due to the activity of the powerful, protective lactoperoxidase system (LPO) which prevents serious airborne infections. The LPO system requires iodine, which is liberally provided by the typical Japanese diet but lacking in many others. One might consider the Japanese experience an incredibly large, open-label study exhibiting the preventative power of a high-iodine diet. We predict this favourable trend will continue for Japan because deadly variants of the severe, acute respiratory syndrome coronavirus 2 will be with us, forever.How to cite this article: Smith ML, Sharma S, Singh TP. High dietary iodine intake may contribute to the low death rate from COVID-19 infection in Japan with activation by the lactoperoxidase system.

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“…As this virus mainly penetrates mucosal epithelial cells, mucosal immunity may be an important parameter influencing the infection course. The induction of a strong local immune response may be crucial for the initial control of the virus and for paving the way to an effective adaptive immune response [152]. Mucosal immune responses are initiated at inductive sites in nasopharynx-associated lymphoid tissues and lead to the production of secretory IgA.…”

Section: Immunology Of Covid-19mentioning

confidence: 99%

COVID-19 and Dentistry in 72 Questions: An Overview of the Literature

Derruau

Bouchet

Nassif

et al. 2021

JCM

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The outbreak of Coronavirus Disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has significantly affected the dental care sector. Dental professionals are at high risk of being infected, and therefore transmitting SARS-CoV-2, due to the nature of their profession, with close proximity to the patient’s oropharyngeal and nasal regions and the use of aerosol-generating procedures. The aim of this article is to provide an update on different issues regarding SARS-CoV-2 and COVID-19 that may be relevant for dentists. Members of the French National College of Oral Biology Lecturers (“Collège National des EnseignantS en Biologie Orale”; CNESBO-COVID19 Task Force) answered seventy-two questions related to various topics, including epidemiology, virology, immunology, diagnosis and testing, SARS-CoV-2 transmission and oral cavity, COVID-19 clinical presentation, current treatment options, vaccine strategies, as well as infection prevention and control in dental practice. The questions were selected based on their relevance for dental practitioners. Authors independently extracted and gathered scientific data related to COVID-19, SARS-CoV-2 and the specific topics using scientific databases. With this review, the dental practitioners will have a general overview of the COVID-19 pandemic and its impact on their practice.

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Oromucosal immunomodulation as clinical spectrum mitigating factor in SARS‐CoV‐2 infection

Cited by 7 publications

References 21 publications

Bovine Coronavirus Immune Milk Against COVID-19

Bovine Coronavirus Immune Milk Against COVID-19

High dietary iodine intake may contribute to the low death rate from COVID‐19 infection in Japan with activation by the lactoperoxidase system

COVID-19 and Dentistry in 72 Questions: An Overview of the Literature

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