Origin of the Human Basal Cell Epithelioma**From the Department of Dermatology, Wayne State University College of Medicine, Detroit, Michigan.

Zackheim, Herschel S.

doi:10.1038/jid.1963.152

Cited by 65 publications

(3 citation statements)

References 10 publications

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“…These findings indicate that histogenetically the origin cell of BCC is from the basal cell of epidermis, located at the interfollicular epidermis and infundibulum of the hair follicle distributed along the basal layer, supporting the theories that the origin of BCC arises from the basal cell layer of the interfollicular epidermis [8, 27], not the ORS and hair follicles [15, 28]. …”

Section: Discussionsupporting

confidence: 74%

Basal Cell Carcinoma Arises from Interfollicular Layer of Epidermis

Tan

Ghaznawie

Heenan³

et al. 2018

Journal of Oncology

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Background BCC is currently the most common type of skin cancer in humans. Although having a low-grade malignancy and metastatic potential, BCC is locally aggressive and destructive. Despite numerous studies, the origin of BCC, whether arising from the follicular or interfollicular layer, remains controversial. Objectives This study aims to evaluate whether BCC arises from the follicular or interfollicular layer by using immunohistochemical staining. Methods Twenty-three specimens of superficial and nodular BCC at its very early stage were examined. The samples were immunohistochemically stained using BerEP4 antibody. The stained specimens were then examined and scored by 2 independent observers. Results BerEP4 was found to be strongly positive in all BCC lesions, including a very early lesions budding off the basal layer of the epidermis. Conclusion This study confirmed that the origin site of BCC is basal layer of epidermis. This finding suggests that BCC arises from the interfollicular epidermis.

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Section: Discussionsupporting

confidence: 74%

Basal Cell Carcinoma Arises from Interfollicular Layer of Epidermis

Tan

Ghaznawie

Heenan³

et al. 2018

Journal of Oncology

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“…Originally, the tumor was regarded as deriving from the basal cells of the epidermis (1). Although the site of origin of the BCC is usually considered to be the surfaee epidermis (3), the tumor has also been suggested as originating from the hair follicle epithelial cells (4). Although the site of origin of the BCC is usually considered to be the surfaee epidermis (3), the tumor has also been suggested as originating from the hair follicle epithelial cells (4).…”

mentioning

confidence: 99%

“…Later, it was suggested to originate from pluripotential epithelial germ cells, able to differentiate toward different epidermal appendages (2). Although the site of origin of the BCC is usually considered to be the surfaee epidermis (3), the tumor has also been suggested as originating from the hair follicle epithelial cells (4). Analysis of eytokeratin polypeptides of BCC has recently revealed a related keratin pattern in these tumors and in the cells of the pilosebaceous tract (5).…”

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confidence: 99%

Cellular differentiation of basal cell carcinoma studied with fluorescent lectins and cytokeratin antibodies

et al. 1984

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The expression of cellular glycoconjugates and cytokeratin polypeptides in 8 basal cell carcinomas (BCC) was studied using fluorochrome-coupled lectins and different keratin-antibodies. Peanut agglutinin and Wistaria floribunda agglutinin, binding to all layers of normal human epidermis, also stained all cells in the basal cell carcinomas. Dolichos biflorus agglutinin, which in normal epidermis binds only to the basal cells, gave a mottled staining pattern in most of the tumors. Instead, Ulex europaeus I agglutinin and soybean agglutinin, which in normal epidermis only bind to the spinous and granular cell layers, did not stain tumor cells in basal cell carcinomas. Rabbit antibodies to human 43-50kD epidermal keratin polypeptides and 2 monoclonal cytokeratin antibodies, PKK1 reacting only with follicular epithelium, and PKK2 reacting also with the basal epidermal cells, brightly stained all cells of the basal cell carcinomas studied, whereas antibodies to human 60-67kD epidermal keratin polypeptides did not bind to the carcinoma cells. The results suggest that the cells in basal cell carcinomas resemble epidermal basal cells both by their glycoconjugate pattern and keratin expression. However, the tumor cells also express cytokeratins, which can be found only in the follicular epithelium, but not in normal interfollicular epidermis.

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Basal Cell Carcinoma With Pulmonary and Lymph Node Metastasis Causing Death

Robinson

Dahiya

2003

Arch Dermatol

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Background:The incidence of metastatic basal cell carcinoma ranges from 0.003% to 0.55%. The 230 reported cases most often occurred in long-standing recurrent lesions and appeared in regional nodes or the lungs.Observations: The stromal dependence of the tumor provides an explanation for the nonmetastasizing nature of basal cell carcinoma. The dense fibrous stroma of the lymph node in the case of metastatic basal cell carcinoma reported in the present study is similar to other reported cases with metastases to lymph nodes, bone, bone marrow, glands, and subcutaneous tissue.Conclusions: This metastatic basal cell carcinoma demonstrated lymphatic and hematogenous dissemination to the lungs and lymph nodes. A dense accumulation of microvessels was present at the boundary of the tumor nests and dermal stroma and in the stroma surrounding the tumor in the lymph node.

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Origin of the Human Basal Cell Epithelioma**From the Department of Dermatology, Wayne State University College of Medicine, Detroit, Michigan.

Cited by 65 publications

References 10 publications

Basal Cell Carcinoma Arises from Interfollicular Layer of Epidermis

Basal Cell Carcinoma Arises from Interfollicular Layer of Epidermis

Cellular differentiation of basal cell carcinoma studied with fluorescent lectins and cytokeratin antibodies

Basal Cell Carcinoma With Pulmonary and Lymph Node Metastasis Causing Death

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