1978
DOI: 10.1001/archderm.114.5.732
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Origin of familial malignant melanomas from heritable melanocytic lesions. 'The B-K mole syndrome'

Abstract: Distinctive melanocytic moles are described in 37 patients from six melanoma families. Among the family members examined by the authors, 15 of 17 patients with melanoma and 22 of 41 nonmelanoma relatives had the unique moles. The clinical and histological features of these moles have been designated the "B-K mole syndrome." The clinical features of the syndrome include the presence of less than 10 to greater than 100 moles prominent of the upper trunk and extremities, and variability of mole size (5 mm to 15 m… Show more

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Cited by 284 publications
(179 citation statements)
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“…The features seen in these nevi are similar to the changes referred to as the B-K mole syndrome described by Clark et al (1978) and Reimer et al (1978). These authors use the term "atypical melanocytic hyperplasia".…”
Section: Discussionsupporting
confidence: 57%
See 1 more Smart Citation
“…The features seen in these nevi are similar to the changes referred to as the B-K mole syndrome described by Clark et al (1978) and Reimer et al (1978). These authors use the term "atypical melanocytic hyperplasia".…”
Section: Discussionsupporting
confidence: 57%
“…We have compared them with descriptions of the histopathology of the B-K moles described by Clark et al (1978).…”
mentioning
confidence: 99%
“…The significance of the cutaneous phenotype was not originally recognized in this family. Nevertheless, the striking mela noma cluster was maintained in our registry for a decade until it was ob served in two other families, one of which was reported by Clark et al 48 The eventual demonstration of the phe notype in the family discussed above demonstrates the utility of longitudinal monitoring of such kindreds.…”
Section: Familial Atypical Multiple Mole-melanoma Syndrome (Fammm)mentioning
confidence: 59%
“…These observations led this surgeon to suggest that the disease was hereditary. This may have been the first example of the familial atypical multiple mole-melanoma syndrome (FAMMM) Frichot et al, 1977), which has also been referred to by the following names: the B-K Mole Syndrome (Greene & Fraumeni, 1979;Clark et al, 1978;Reimer et al, 1978) th-e Dysplastic Naevus Syndrome (DNS) (Elder et al, 1980) and the Large Atypical Naevus Syndrome (LANS) (Bondi et al, 1981).…”
mentioning
confidence: 99%