Organotin(IV) complexes of 2-hydroxyacetophenone-N(4)-cyclohexylthiosemicarbazone (H2dact): Synthesis, spectral characterization, crystal structure and biological studies

Abstract

Sn NMR spectral studies. The molecular structure of complex (5) has also been determined by single-crystal X-ray diffraction. The crystal structure of complex (5) showed that the ligand is doubly deprotonated at the oxygen and sulfur atoms and is coordinated to the tin(IV) atom through thiolate-S, azomethine-N and phenoxide-O atoms. X-ray diffraction studies indicated that complex (5) is a monomer and the central tin(IV) atom is five coordinated in a distorted trigonal bipyramidal geometry. The cytotoxicity of the ligand (1) as well as its organotin(IV) complexes (2-5) was studied against Artemia salina. The in vitro antibacterial activities of these compounds were also evaluated. The screening results have shown that the organotin(IV) complexes (2-5) have better antibacterial activity than the free ligand. Furthermore, it has been shown that diphenyltin(IV) derivative (5) exhibits significantly better activity than the monoorganotin(IV) derivatives (2-4).

Diorganotin(IV) complexes of 3,5-dichloro-2-hydroxybenzaldehyde-N(4)-ethylthiosemicarbazone: Synthesis, spectral characterization and crystal structure

“…The Sn1-O1 bond distance (2.08 Å) is almost close to the covalent radii of Sn-O (2.10 Å) and comparable with those reported in articles [54,55]. The Sn1-S1 bond length (2.495 Å) was found close to the sum of the covalent radii of Sn-S (2.42 Å) [56], indicating thiolate sulfur bonded to the Sn moiety after deprotonation and is comparable with the reported values for Sn-S (2.50 Å) in [Ph 2 Sn(dact)] [57]. The two phenyl groups are bonded to the tin(IV) atom [Sn1-C11 = 2.1269(12) Å, Sn1-C17 = 2.1326(12) Å which are slightly shorter than the non-polar covalent radii of Sn-C (2.17 Å) [53], but are comparable with other reported diorganotin(IV) complexes [43,58].…”

New organotin(IV) complexes with N(4)-methylthiosemicarbazone derivatives prepared from 2,3-dihydroxybenzaldehyde and 2-hydroxy-5-methylbenzaldehyde: synthesis, characterization, and cytotoxic activity

“…Thiosemicarbazones have become an area of intensive study because of their biological activities and have obtained much attention [7][8][9]. Thiosemicarbazone derivatives with tridentate donor sites would provide the five-coordinate environment to the metal center [10][11][12]. Thiosemicarbazone with ONS donors have received attention in the expansion of coordination chemistry as they easily form complexes with metal ions [13][14][15].…”

Microwave assisted synthesis of disubstituted benzyltin arylformylhydrazone complexes: anticancer activity and DNA‐binding properties

“…The results of the FT‐IR study are consistent with the X‐ray structure. In addition, the typical absorptions for Sn‐C, Sn‐O, and Sn‐O‐Sn vibrations in the complexes are located in the normal ranges based on similar organotin compounds …”