Organotin(IV) Carboxylates as Promising Potential Drug Candidates in the Field of Cancer Chemotherapy

Abstract

Medicinal inorganic chemistry plays an important role in exploring the properties of metal ions for the designing of new drugs. The field has been stimulated by the success of cis-platin, the world best selling anticancer drug and platinum complexes with reduced toxicity, oral activity and activity against resistant tumors are currently on clinical trial. The use of cis-platin is, however, severely limited by its toxic side-effects. This has stimulated chemists to employ different strategies in the development of new metal-based anticancer agents with different mechanisms of action. The discovery of new non-covalent interactions with the classical target, DNA, was the first developing step in the treatment of cancer. The use of organometallic compounds as a medicine is very common now a days because it offers potential advantages over the more common organic-based drugs. In this article we have highlighted the anticancer activity of the organotin(IV) carboxylates published in the last few years (from 2008 to 2016). In most cases they present lower IC50 values than those of cisplatin, which indicates their high activity against the cancer cell lines. The summarized data reveal that every year new organotin(IV) carboxylate complexes are synthesized with the aim of new anticancer agent with much better results than the than the corresponding activity of cis-platin or other clinically approved drugs. In addition to the advantages of high activity, compared to the platinum compound, tin complexes are much cheaper. Thus by using organotin carboxylate for clinical medicine, cost reduction, dosage reduction and effect enhancement will be reached.

Tin Complexes of 4-(Benzylideneamino)benzenesulfonamide: Synthesis, Structure Elucidation and Their Efficiency as PVC Photostabilizers

“…The most common PVC stabilizers include Schiff bases [24][25][26][27][28], polybenzimidazoles [29], polyphosphates [30], pigments [31], zinc oxide [32], and titanium dioxide [33,34]. Tin complexes containing organic moieties have high stability and are used in many medicinal and industrial applications [35][36][37][38]. The efficiency of tin complexes is highly dependent on the organic moieties and substituents attached to the tin (Sn) atom [39].…”

Photostabilization of Poly(vinyl chloride) Films Blended with Organotin Complexes of Mefenamic Acid for Outdoor Applications

“…Compounds containing tin have unique physical and chemical properties and are widely used in the pharmaceutical industry [31]. Organotin compounds containing carboxylate moiety showed potential for use as a cancer chemotherapy drug [32]. They can be used as antimicrobials [33], anti-inflammatory agents [34], antitubercular agents [35], biocides and wood preservatives [36], and catalysts [37].…”

Cytotoxic Activity of Organotin(IV) Derivatives with Triazolopyrimidine Containing Exocyclic Oxygen Atoms

“…Organotin (IV) compounds have been receiving increasing attention over the past years [1][2][3][4][5][6] due to their possible use as biologically active non-platinum chemotherapeutic agents, that might have lower toxicity, better excretion properties and fewer side effects than platinum based drugs [7][8][9]. These compounds, even at low doses, present high anti-proliferative activity which, in some cases, is higher than that of cisplatin.…”