Organoselenium‐Catalyzed Regioselective C−H Pyridination of 1,3‐Dienes and Alkenes

Abstract

An efficient approach for organoselenium-catalyzed regioselective C À Hp yridination of 1,3-dienes to form pyridinium salts has been developed. This method was also successfully applied to direct CÀHp yridination of alkenes.F luoropyridinium reagents,o ri nitially loaded pyridine derivatives, acted as pyridine sources in the pyridination reactions.T he obtained pyridinium salts could be further converted under different conditions.This work is the first example of catalytic C-2 direct CÀHf unctionalization of 1,3-dienes and the first case of organoselenium-catalyzed CÀHp yridination.Supportinginformation for this article can be found under: http://dx.Scheme 5. Further transformations of pyridinium salts. Scheme 6. Mechanistic exploration. Angewandte Chemie Communications

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