2009
DOI: 10.1590/s0103-50532009000300003
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Os agentes de guerra química constituem uma das maiores ameaças do mundo moderno. Dentre estes, destacam-se os agentes neurotóxicos, em virtude de sua alta letalidade e periculosidade. Eles são compostos organofosforados que atuam pela inibição da enzima acetilcolinesterase, a qual é fundamental no processo de transmissão de impulsos nervosos. Existem várias formas de tratamento para a intoxicação por organofosforados, mas nenhuma delas é eficaz contra todos os agentes conhecidos ou contra todos os seus efeito… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4

Citation Types

0
170
0
9

Year Published

2011
2011
2019
2019

Publication Types

Select...
6
1

Relationship

1
6

Authors

Journals

citations
Cited by 215 publications
(179 citation statements)
references
References 144 publications
0
170
0
9
Order By: Relevance
“…Acetylcholinesterase hydrolyses acetylcholine and is mainly associated with nerves and muscles, being typically found on the synapses, while butyrylcholinesterase hydrolyses butyrylcholine and is synthesized by the liver, being found in large concentration in serum [8].…”
Section: Introductionmentioning
confidence: 99%
“…Acetylcholinesterase hydrolyses acetylcholine and is mainly associated with nerves and muscles, being typically found on the synapses, while butyrylcholinesterase hydrolyses butyrylcholine and is synthesized by the liver, being found in large concentration in serum [8].…”
Section: Introductionmentioning
confidence: 99%
“…The aging process occurs at different times, depending on the nature of the organophosphorus compound. 1,[21][22][23][24][25] An understanding of the processes and mechanisms behind the reactivation of the inhibited AChE (11) is required to develop new drugs for the treatment of intoxication with neurotoxic organophosphorus agents. 10 The most effective reported reactivation compounds are cationic oximes prepared from pyridine aldehydes.…”
Section: Introductionmentioning
confidence: 99%
“…Intoxication with neurotoxic organophosphorus compounds is a serious problem caused by some pesticides used in agriculture, such as paraoxon (1) and malathion (2) ( Figure 1) and chemical warfare agents. [1][2][3][4][5][6][7][8][9][10][11] According to the World Health Organization, there are about 220,000 intoxications with organophosphorus pesticides throughout the world every year, leading to approximately 20,000 deaths.…”
Section: Introductionmentioning
confidence: 99%
See 2 more Smart Citations