Organophosphate Nerve Agents

Magnetic mesoporous Fe 3 O 4 @ n SiO 2 @ m SiO 2 nanoparticles for high-throughput mass spectrometry detection of hydrolyzed products of organophosphorus nerve agents

“…When analyzing real samples of OPNAs, the concentration of target compounds was large, and the LODs of DART-MS/MS were 2.50–5.00 ng mL −1 , which meets the detection standard of 1.00 μg mL −1 according to the scheduled compound detection standard, 30,31 and is suitable for the detection and analysis of MPs in the environment. Meanwhile, the key role of the M-QuEChERS–DART-MS/MS method is to enable the rapid detection of MPs in the first period of time after OPNA exposure.…”

Magnetic mesoporous Fe 3 O 4 @ n SiO 2 @ m SiO 2 nanoparticles for high-throughput mass spectrometry detection of hydrolyzed products of organophosphorus nerve agents

“…When analyzing real samples of OPNAs, the concentration of target compounds was large, and the LODs of DART-MS/MS were 2.50–5.00 ng mL −1 , which meets the detection standard of 1.00 μg mL −1 according to the scheduled compound detection standard, 30,31 and is suitable for the detection and analysis of MPs in the environment. Meanwhile, the key role of the M-QuEChERS–DART-MS/MS method is to enable the rapid detection of MPs in the first period of time after OPNA exposure.…”

Machine learning in drug design: Use of artificial intelligence to explore the chemical structure–biological activity relationship

“…As a consequence, flaccid paralysis of all muscles in the body occurs. The immediate cause of death is asphyxiation caused by paralysis of the diaphragm muscle 81 . In this case, both tested and comparable models were not very accurate, although both correctly predicted toxicity (EPA, class I).…”

Simple Chemical and Cholinesterase Methods for the Detection of Nerve Agents Using Optical Evaluation

“…The action of organophosphorus NAs is that they covalently bind to the enzyme at the active site via the serine (OH group), phosphorylate it, and irreversibly inhibit it. The consequence of this inhibition is continuous signal transduction and overstimulation of the corresponding cells [4,5].…”

Magnetic mesoporous Fe 3 O 4 @ n SiO 2 @ m SiO 2 nanoparticles for high-throughput mass spectrometry detection of hydrolyzed products of organophosphorus nerve agents

“…When analyzing real samples of OPNAs, the concentration of target compounds was large, and the LODs of DART-MS/MS were 2.50–5.00 ng mL −1 , which meets the detection standard of 1.00 μg mL −1 according to the scheduled compound detection standard, 30,31 and is suitable for the detection and analysis of MPs in the environment. Meanwhile, the key role of the M-QuEChERS–DART-MS/MS method is to enable the rapid detection of MPs in the first period of time after OPNA exposure.…”

Machine learning in drug design: Use of artificial intelligence to explore the chemical structure–biological activity relationship

“…As a consequence, flaccid paralysis of all muscles in the body occurs. The immediate cause of death is asphyxiation caused by paralysis of the diaphragm muscle 81 . In this case, both tested and comparable models were not very accurate, although both correctly predicted toxicity (EPA, class I).…”

Simple Chemical and Cholinesterase Methods for the Detection of Nerve Agents Using Optical Evaluation

“…The action of organophosphorus NAs is that they covalently bind to the enzyme at the active site via the serine (OH group), phosphorylate it, and irreversibly inhibit it. The consequence of this inhibition is continuous signal transduction and overstimulation of the corresponding cells [4,5].…”

Magnetic mesoporous Fe 3 O 4 @ n SiO 2 @ m SiO 2 nanoparticles for high-throughput mass spectrometry detection of hydrolyzed products of organophosphorus nerve agents

“…When analyzing real samples of OPNAs, the concentration of target compounds was large, and the LODs of DART-MS/MS were 2.50–5.00 ng mL −1 , which meets the detection standard of 1.00 μg mL −1 according to the scheduled compound detection standard, 30,31 and is suitable for the detection and analysis of MPs in the environment. Meanwhile, the key role of the M-QuEChERS–DART-MS/MS method is to enable the rapid detection of MPs in the first period of time after OPNA exposure.…”

Machine learning in drug design: Use of artificial intelligence to explore the chemical structure–biological activity relationship

“…As a consequence, flaccid paralysis of all muscles in the body occurs. The immediate cause of death is asphyxiation caused by paralysis of the diaphragm muscle 81 . In this case, both tested and comparable models were not very accurate, although both correctly predicted toxicity (EPA, class I).…”

Simple Chemical and Cholinesterase Methods for the Detection of Nerve Agents Using Optical Evaluation

“…The action of organophosphorus NAs is that they covalently bind to the enzyme at the active site via the serine (OH group), phosphorylate it, and irreversibly inhibit it. The consequence of this inhibition is continuous signal transduction and overstimulation of the corresponding cells [4,5].…”