Organochlorine Pollutants and Female Fertility: A Systematic Review Focusing on In Vitro Fertilization Studies

Kadhel, Philippe; Monnier, Patricia; Boucoiran, Isabelle; Chaillet, Nils; Fraser, William D.

doi:10.1177/1933719112446077

Cited by 11 publications

(3 citation statements)

References 87 publications

(165 reference statements)

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“…for 7 days showed a reduction in seminal vesicle weight, serum testosterone, and dehydroepiandrosterone levels [ 10 ] while mature female rabbits exposed to dichlorodiphenyltrichloroethane (DDT) (3 mg kg −1 ) and lindane (0.8 mg kg −1 ) exhibited reduced ovulation rates [ 11 ]. Although several in-vitro studies (e.g., studies using ovarian cells) have listed the negative impacts of DDE and DDT, such as infertility and reductions in the number, development or quality of oocytes, fertilization rate, embryo quality or development, and pregnancy rate, only a few of these studies have managed to obtain statistically significant results [ 12 ]. An epidemiological study reported that high levels of serum ΣDDT (DDE + DDT) above 1 μg kg −1 were significantly correlated to low pregnancy rates in German women [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Association between Organochlorine Pesticide Levels in Breast Milk and Their Effects on Female Reproduction in a Taiwanese Population

Chen

Santos

Que

et al. 2018

IJERPH

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Only few studies have focused on organochlorine pesticides (OCPs) in breast milk and the related health risks for women in Taiwan. Our goal is to examine breast milk OCPs and their associations with female reproductive function (infertility, gynecological diseases, and menstruation characteristics) as well as their correlation with sociodemographic parameters (age, pre-pregnant body mass index (BMI), annual incomes, population, birth year, and parity) and dietary habit. The breast milk samples were collected in southern Taiwan (n = 68) from 2013 to 2016 and the OCP residues were analyzed using high resolution gas chromatography with low resolution mass spectrometry (HRGC/LRMS). The results show that the most abundant OCP residues in the breast milk was ΣDDT with the geometric mean ± standard deviation of 9.81 ± 7.52 ng−1 lipid−1 followed by ΣHCH (0.539 ± 0.557 ng−1·lipid−1). In the principal component analysis, cis-chlordane (cis-CHL) and γ-HCH were found to be related to participants who received medical treatment for infertility, and 4,4′-DDT was associated with those who received gynecological surgery. The logistic regression showed that the odds ratio (OR) of log γ-hexachlorocyclohexane (γ-HCH) was higher for mothers who had received medical treatment for infertility than for the normal group (OR = 25.6, p = 0.035) after adjustments for age, pre-pregnant BMI, annual income, population (i.e., native-born Taiwanese), birth year, and parity. Cow milk and beef consumption as well as menstruation characteristics such as average menstrual period (>5 days), shortest menstrual period (<3 days), and women who had taken hormonal drugs were significantly associated to several OCP residues in the breast milk. In addition, ΣHCH including β-HCH and γ-HCH was correlated with annual family income and gravidity as well as cow milk and beef consumptions. Overall, γ-HCH exhibited a probable association with the infertility diseases of Taiwanese women, and dietary habit might play an important role in the female Taiwanese exposure to OCPs.

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Section: Introductionmentioning

confidence: 99%

Association between Organochlorine Pesticide Levels in Breast Milk and Their Effects on Female Reproduction in a Taiwanese Population

Chen

Santos

Que

et al. 2018

IJERPH

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“…In the last decades, assisted reproduction treatments have increased, including IVF. The IVF studies allow acquiring evidence on the impact of environmental pollutants on embryo quality (Kadhel et al, 2012).…”

Section: In Vitro Fertilizationmentioning

confidence: 99%

Update about the disrupting‐effects of phthalates on the human reproductive system

Mesquita

Lorigo

Cairrão

2021

Molecular Reproduction Devel

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Phthalate esters are synthetic chemicals used in the plastic industry as plasticizers and consumable products. According to United Nations, about 400 million tons of plastic are produced every year. In parallel with increased production, the concerns about its effects on human health have increased because phthalates are endocrinedisrupting compounds. Humans are continuously exposed to phthalates through different routes of exposure. Experimental data have associated the phthalates exposure to adverse effects on development and reproduction in women (e.g., earlier puberty, primary ovarian insufficiency, endometriosis, preterm birth, or in vitro fertilization) and men (e.g., anogenital distance, cryptorchidism, hypospadias, and changes in adult reproductive function) although there is no consensus. Therefore, one question arises: could the increase in infertility be related to phthalates exposure? To answer this question, we aimed to assess the disruptingeffects of phthalates on the human reproductive system. For this, we reviewed the current literature based on epidemiological and experimental data and experimental studies in humans. The phthalate effects were discussed in a separate mode for female and male reproductive systems. In summary, phthalates induce toxicity in the reproductive system and human development. The increased plastic production may be related to the increase in human infertility.

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“…The presence of DDE, MXC, or simazine (a triazine herbicide) was associated with follicular atresia (34). Given that MXC, simazine, and other pesticides (as atrazine, endosulfan, and chlordecone) are oestrogen receptor agonists (in contrast to DDE, DDT, and vinclozolin), they may have oestrogenic and/or antiandrogenic effects (5,10,35,36). This implicitly explains why some specific pesticides could be responsible for various female reproductive diseases to differing extents and why the effects of some pesticide compounds (such as DDE, PCB, and MXC) depend on the patient's genetic predisposition.…”

Section: The Association Between Pesticide Exposure and Certain Femalmentioning

confidence: 99%

The impact of endocrine disruptor chemicals on oocyte/embryo and clinical outcomes in IVF

Cabry¹,

Merviel²,

Madkour

et al. 2020

Endocrine Connections

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The negative impact of endocrine-disrupting pesticides on human fertility is now a key issue in reproductive health. There are much fewer literature data about the impact of pesticide exposure on women than on men and very few studies of women participating in an in vitro fertilization (IVF) programme. In the present review, we found that (1) various pesticides with an endocrine-disrupting action are associated with poor oocyte maturation and competency, embryonic defects and poor IVF outcomes, and (2) some pesticide compounds are linked to specific causes of female infertility, such as premature ovarian insufficiency, polycystic ovarian syndrome, and endometriosis. IVF participants living in agricultural regions should be informed about the fertility decline, low ongoing pregnancy rates, and elevated risk of miscarriage associated with exposure to high doses of pesticides.

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Organochlorine Pollutants and Female Fertility: A Systematic Review Focusing on In Vitro Fertilization Studies

Cited by 11 publications

References 87 publications

Association between Organochlorine Pesticide Levels in Breast Milk and Their Effects on Female Reproduction in a Taiwanese Population

Association between Organochlorine Pesticide Levels in Breast Milk and Their Effects on Female Reproduction in a Taiwanese Population

Update about the disrupting‐effects of phthalates on the human reproductive system

The impact of endocrine disruptor chemicals on oocyte/embryo and clinical outcomes in IVF

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