Organizing pneumonia in patients with severe respiratory failure due to novel A (H1N1) influenza

Cornejo, Rodrigo; Llanos, Osvaldo; Fernández, Cristina; Díaz, Juan Carlos; Cardemil, Gonzalo; Salguero, Jorge; Luengo, Cecilia; Tobar, Eduardo; Romero, Carlos; Gálvez, Luis Ricardo

doi:10.1136/bcr.02.2010.2708

Cited by 42 publications

(48 citation statements)

References 21 publications

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“…To date, six cases of post‐influenza organizing pneumonia have been reported in the literature; all had influenza A infection, and most were infected by H1N1 strain . The usual presenting features included refractory respiratory failure during the infective episodes and incomplete recovery after antiviral therapy.…”

Section: Discussionmentioning

confidence: 99%

Influenza B/Streptococcal co‐infection complicated by organizing pneumonia

Kwok

Lam

Wong

et al. 2016

Respirology Case Reports

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Organizing pneumonia is a rare complication of influenza infection that has substantial morbidity. We report the first case of organizing pneumonia associated with influenza B and Streptococcus pneumoniae coinfection that had significant improvement with corticosteroid treatment. The clinical and radiological features of organizing pneumonia associated with this coinfection are similar to those after influenza A infection. Timely use of systemic glucocorticosteroids would be of benefit in promoting resolution for influenza‐associated organizing pneumonia.

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Section: Discussionmentioning

confidence: 99%

Influenza B/Streptococcal co‐infection complicated by organizing pneumonia

Kwok

Lam

Wong

et al. 2016

Respirology Case Reports

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“…Our team has developed experience in prolonged prone ventilation as a protocolized routine therapy for severe ARDS [12], recently applied during the 2009 flu pandemic [13]. In addition, several procedures are performed in prone positioning in ARDS patients in our unit, as the installation of intravascular devices using ultrasound-guided central catheter insertions in the case of central venous and artery pulmonary catheters, fiber optic bronchoscopy, and transesophageal echocardiography; the latter has been reported in other centers [14, 15].…”

Section: Discussionmentioning

confidence: 99%

Prone Position Ventilation Used during a Transfer as a Bridge to Ecmo Therapy in Hantavirus-Induced Severe Cardiopulmonary Syndrome

Cornejo

Ugalde

Llanos

et al. 2013

Case Reports in Critical Care

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Background. Transport of critically ill patients is a complex issue. We present a case using prone positioning as a bridge to extracorporeal membrane oxygenation (ECMO), performed by a critical retrieval team from a university hospital. Case Report. A 28-year-old male developed fever, progressive respiratory failure, and shock. He was admitted to ICU from a public hospital, and mechanical ventilation was begun, but clinical response was not adequate. ECMO was deemed necessary due to severe respiratory failure and severe shock. A critical retrieval team of our center was assembled to attempt transfer. Prone positioning was employed to stabilize and transfer the patient, after risk-benefit assessment. Once in our hospital, ECMO was useful to resolve shock and pulmonary edema secondary to Hantavirus cardiopulmonary syndrome. Finally, he was discharged with normal functioning. Conclusion. This case exemplifies the relevance of a retrieval team and bridge therapy. Prone positioning improves oxygenation and is safe to perform as transport if performed by a trained team as in this case. Preparation and organization is necessary to improve outcomes, using teams and organized networks. Catastrophic respiratory failure and shock should not be contraindications to transferring patients, but it must be done with an experienced team.

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“…Cornejo et al [40] Case report Two patients with H1N1 that developed organizing pneumonia Methylprednisolone 500 mg/d for 3 d…”

Section: Clinical Improvementmentioning

confidence: 99%

“…Case reports suggested beneficial use in specific contexts, such as organizing pneumonia [40] , post-viral inflammatory pneumonitis [41] and H1N1 pneumonia in a pregnant woman [42] .…”

Section: Not Reportedmentioning

confidence: 99%

Corticosteroids for severe influenza pneumonia: A critical appraisal

Nedel

Nora

Salluh

et al. 2016

WJCCM

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Influenza pneumonia is associated with high number of severe cases requiring hospital and intensive care unit (ICU) admissions with high mortality. Systemic steroids are proposed as a valid therapeutic option even though its effects are still controversial. Heterogeneity of published data regarding study design, population demographics, severity of illness, dosing, type and timing of corticosteroids administered constitute an important limitation for drawing robust conclusions. However, it is reasonable to admit that, as it was not found any advantage of corticosteroid therapy in so diverse conditions, such beneficial effects do not exist at all. Its administration is likely to increase overall mortality and such trend is consistent regardless of the quality as well as the sample size of studies. Moreover it was shown that corticosteroids might be associated with higher incidence of hospital-acquired pneumonia and longer duration of mechanical ventilation and ICU stay. Finally, it is reasonable to conclude that corticosteroids failed to demonstrate any beneficial effects in the treatment of patients with severe influenza infection. Thus its current use in severe influenza pneumonia should be restricted to very selected cases and in the setting of clinical trials.

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Organizing pneumonia in patients with severe respiratory failure due to novel A (H1N1) influenza

Cited by 42 publications

References 21 publications

Influenza B/Streptococcal co‐infection complicated by organizing pneumonia

Influenza B/Streptococcal co‐infection complicated by organizing pneumonia

Prone Position Ventilation Used during a Transfer as a Bridge to Ecmo Therapy in Hantavirus-Induced Severe Cardiopulmonary Syndrome

Corticosteroids for severe influenza pneumonia: A critical appraisal

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