Organic Phosphorus Poisoning and Its Therapy

Durham, William F.; Hayes, Wayland J.

doi:10.1080/00039896.1962.10663237

Cited by 110 publications

(24 citation statements)

References 66 publications

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“…13 Since RBC values may vary by 10% on retesting, an increase of less than 10% over the previous value may show that a plateau has been reached. Values at the lower limit of the normal range should be evaluated more strictly.…”

Section: Methodsmentioning

confidence: 99%

Clinical Confirmation of Organophosphate Poisoning by Serial Cholinesterase Analyses

Coye¹,

Barnett²,

Midtling³

et al. 1987

Arch Intern Med

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Section: Methodsmentioning

confidence: 99%

Clinical Confirmation of Organophosphate Poisoning by Serial Cholinesterase Analyses

Coye¹,

Barnett²,

Midtling³

et al. 1987

Arch Intern Med

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“…The inhibition of AChE in the red blood cell is approximately in parallel with that of the nerves, muscle and glands and has been justified as an index of tissue inhibition (6). were performed when appropriate.…”

mentioning

confidence: 99%

Acetylcholinesterase inhibitor, pyridostigmine bromide, reduces skin blood flow in humans

Stephenson

Kolka

1990

American Journal of Physiology-Regulatory, Integrative and Comp

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Five subjects exercised on a cycle ergometer for 30 min at 55% peak oxygen consumption on two occasions in an environmental test chamber (ambient temperature = 29 degrees C; dew point temperature = 10 degrees C). Pyridostigmine bromide (PYR), an acetylcholinesterase (AChE) inhibitor, was ingested (30 mg) approximately 150 min before one experiment, and no drug was administered during the other experiment (control). Red blood cell AChE inhibition averaged 40 (+/- 7)% during PYR treatment. Esophageal temperature (Tes), an eight site-derived mean skin temperature, forearm blood flow (FBF; venous occlusion plethysmography), skin blood flow (SkBF; laser-Doppler velocimetry), and metabolic rate (indirect calorimetry) were measured. SkBF decreased 37% after PYR treatment compared with control (P less than or equal to 0.05). The Tes threshold for initiation of cutaneous vasodilation was 36.8 (+/- 0.3) degrees C for the control treatment and 37.0 (+/- 0.3) degrees C for the PYR treatment (P less than or equal to 0.01). FBF was not significantly different between treatments, whereas heart rate was reduced by 7 and 9 beats/min during rest and exercise, respectively (P less than or equal to 0.01). The increased threshold for initiation of cutaneous vasodilation with AChE inhibition by PYR is compatible with nonthermal modulation of the control of thermoregulation through increased acetylcholine (ACh) accumulation. This could potentiate preganglionic transmission to enhance adrenergic vasoconstrictor tone. One suggested mechanism possible at the neuroeffector junction of the sweat gland may be that accumulated ACh diffusion across the adventitia of adjacent arterioles to muscarinic receptors initiates contraction of the smooth muscle.(ABSTRACT TRUNCATED AT 250 WORDS)

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“…29 The overall mortality rate in this study was 9%. Mortality rate was 5.5% in a study by Malik 23 and 8% in the study by Aziza, et al 22 In some other studies 22,30,31 , it varied from 12% to 27%. We observed that mortality rate was much higher in patients who required mechanical ventilation (40%) as compared to the patients managed on spontaneous breathing (2.2 %).…”

Section: Duration Of Stay N (%)mentioning

confidence: 89%

Management of Acute Organophosphorus Insecticide Poisoning: An Experience at a University Hospital

Shaikh¹,

Siddiqui²,

Soomro³

2008

j liaquat uni med health sci

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Organic Phosphorus Poisoning and Its Therapy

Cited by 110 publications

References 66 publications

Clinical Confirmation of Organophosphate Poisoning by Serial Cholinesterase Analyses

Clinical Confirmation of Organophosphate Poisoning by Serial Cholinesterase Analyses

Acetylcholinesterase inhibitor, pyridostigmine bromide, reduces skin blood flow in humans

Management of Acute Organophosphorus Insecticide Poisoning: An Experience at a University Hospital

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