Organic Nanoparticles Using Microfluidic Technology for Drug‐Delivery Applications

Abstract

The sections in this article are Introduction Batch Synthesis of Organic Nanoparticles Specifications of Reactors: Macroscale versus Microscale Syntheses Properties and Application of Organic Nanoparticles for Drug Delivery Microfluidic Synthesis of Organic Nanoparticles Overview: Unique Features of Microfluidic Reactors for the Controlled Synthesis of Organic Nanoparticles Microfluidic Reactors for Organic Nanoparticles Emulsions Nanoprecipitation Liposomes Controlled Operating Parameters of Microfluidic Reactors Flow Velocity, Microfluidic Dimension, and Mixing Time Mixing Time, Aggression Time, and the Damkohler Number Synthetic Operations Micromixing Online Process of Various Reactants Thermal Control and Heat Transfer Spatial and Temporal Kinetic Control Self‐Assembly Mechanism and Competitive Reaction Microfluidic‐Related Organic Nanoparticles for Drug Delivery Drug Encapsulation and Release Stimuli‐Responsive Release Nanomedicine Delivery to Target Cells Conclusions and Prospective Study Materials, Design, and Fabrication High‐Throughput Microfluidic Processes Controlled Synthesis of Organic Nanoparticles Spatial and Temporal Kinetics Investigation of Nanoparticles

Preparation and statistical optimization of Losartan Potassium loaded nanoparticles using Box Behnken factorial design: Microreactor precipitation

“…Over the past two decades, development of nanoparticles has been gaining more prominence from industries in the field of chemistry, microelectronics, sensors, energy, optic, life sciences Page 3 of 34 A c c e p t e d M a n u s c r i p t 3 and pharmaceutics [1][2][3][4][5]. In pharmaceutical industries, the size and size distribution of nanoparticles plays an important role in drug delivery processes such as sustained release, targeted release and the kinetics of taking away from the body [6].Therefore, nanoparticles have prominent attribute because of their physicochemical properties and better control of process parameters, is vital in order to produce such nanomaterials with desired features [7].…”