Organic-inorganic hybrid nanoflowers: The known, the unknown, and the future

Jafari-Nodoushan, Hossein; Mojtabavi, Somayeh; Faramarzi, Mohammad Ali; Samadi, Nasrin

doi:10.1016/j.cis.2022.102780

Cited by 29 publications

(20 citation statements)

References 215 publications

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“…Recently developed and reviewed methods of obtaining new hybrid nanostructures, named “nanoflowers” [ 55 , 56 , 57 ], were applied for the immobilization of His-tagged PTE [ 29 ]. Usually, chlorides or phosphates of metals are used in the mixture with proteins for the creation of organic–inorganic structures of nanoflowers.…”

Section: Stabilization Of Hexa-histidine-containing Oph For Opc Hydro...mentioning

confidence: 99%

Carrier Variety Used in Immobilization of His6-OPH Extends Its Application Areas

et al. 2023

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Organophosphorus hydrolase, containing a genetically introduced hexahistidine sequence (His6-OPH), attracts the attention of researchers by its promiscuous activity in hydrolytic reactions with various substrates, such as organophosphorus pesticides and chemical warfare agents, mycotoxins, and N-acyl homoserine lactones. The application of various carrier materials (metal-organic frameworks, polypeptides, bacterial cellulose, polyhydroxybutyrate, succinylated gelatin, etc.) for the immobilization and stabilization of His6-OPH by various methods, enables creation of biocatalysts with various properties and potential uses, in particular, as antidotes, recognition elements of biosensors, in fibers with chemical and biological protection, dressings with antimicrobial properties, highly porous sorbents for the degradation of toxicants, including in flow systems, etc. The use of computer modeling methods in the development of immobilized His6-OPH samples provides in silico prediction of emerging interactions between the enzyme and immobilizing polymer, which may have negative effects on the catalytic properties of the enzyme, and selection of the best options for experiments in vitro and in vivo. This review is aimed at analysis of known developments with immobilized His6-OPH, which allows to recognize existing recent trends in this field of research, as well as to identify the reasons limiting the use of a number of polymer molecules for the immobilization of this enzyme.

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Section: Stabilization Of Hexa-histidine-containing Oph For Opc Hydro...mentioning

confidence: 99%

Carrier Variety Used in Immobilization of His6-OPH Extends Its Application Areas

et al. 2023

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“…Graphene oxide is a 2D nanostructure based on SP2-carbon atoms, which contains different oxygen atoms due to the carbon oxidation reaction [ 40 ]. Metal nanoflowers are composed of metal phosphates such as cobalt [ 41 ], copper, manganese, zinc, ferrous, and calcium salts as inorganic components, having larger diameters concerning carbon and gold nanoparticles (100–500 nm). They are characterized by simple synthesis, high stability, larger specific area, good carrier transmission, and enhanced photocatalytic efficiency.…”

Section: Nanomaterials For Sensingmentioning

confidence: 99%

Nanomaterials for Cortisol Sensing

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2022

Nanomaterials

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Space represents one of the most dangerous environments for humans, which can be affected by high stress levels. This can lead to severe physiological problems, such as headaches, gastrointestinal disorders, anxiety, hypertension, depression, and coronary heart diseases. During a stress condition, the human body produces specific hormones, such as dopamine, adrenaline, noradrenaline, and cortisol. In particular, the control of cortisol levels can be related to the stress level of an astronaut, particularly during a long-term space mission. The common analytical methods (HPLC, GC-MS) cannot be used in an extreme environment, such as a space station, due to the steric hindrance of the instruments and the absence of gravity. For these reasons, the development of smart sensing devices with a facile and fast analytical protocol can be extremely useful for space applications. This review summarizes the recent (from 2011) miniaturized sensoristic devices based on nanomaterials (gold and carbon nanoparticles, nanotubes, nanowires, nano-electrodes), which allow rapid and real-time analyses of cortisol levels in biological samples (such as saliva, urine, sweat, and plasma), to monitor the health conditions of humans under extreme stress conditions.

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“…The use of different sources of metals allows the synthesis of a diverse range of antimicrobial nanoparticles, including those derived from silver (Ag), gold (Au), zinc oxide (ZnO), platinum (Pt), palladium (Pd), copper (Cu), iron oxide (Fe 2 O 3 and Fe 2 O 4 ), nickel oxide (NiO), magnesium oxide (MgO), titanium dioxide (TiO 2 ), and indium oxide (In 2 O 3 ). 11 Among various metal-based nanoparticles, gadolinium nanostructures display superior diagnostic and therapeutic potential. 12 Moreover, gadolinium-based nanostructures have demonstrated potent antibacterial activity against some pathogenic bacteria and their antibiotic-resistant variants.…”

Section: Introductionmentioning

confidence: 99%