Beside cultural, social, and educational issues, religious beliefs are assumed to play a significant role on the attitude towards organ transplantation much more often than clinicians believe. At the same time, health-care providers may lack sufficient knowledge on religious issues pertaining to transplantation. This chapter aims to provide an overview on the different religious concepts on organ transplantation. Such knowledge among transplant physicians and surgeons, donor coordinators, and intensivists may provide a background to deal with religious concerns towards organ and tissue donation professionally and appropriately and to increase the transplant numbers.