Oregano demonstrates distinct tumour-suppressive effects in the breast carcinoma model

Abstract

Our results demonstrate, for the first time, a distinct tumour-suppressive effect of oregano in the breast cancer model.

Antineoplastic effects of clove buds (Syzygium aromaticum L.) in the model of breast carcinoma

“…Our experiment remarkably showed the pro‐apoptotic activities of high‐dose CLOs —it was characterized by an increase in the expression of caspase‐3 and Bax/Bcl‐2 ratio in rat mammary carcinomas. We have found similar findings in our earlier experiments reporting the pro‐apoptotic effects of Chlorella pyrenoidosa, fruit peels and oregano using the same rodent model . In our parallel in vitro study, we have demonstrated the decrease in a viability of MCF‐7 cell lines by clove's ethanol extract.…”

“…It is questionable whether an isolated plant secondary metabolite has the similar anticancer activities as the whole‐plant‐based food containing the cocktail of phytochemicals . In this regard, our earlier animal studies (with the same model and similar dosages as in this study) clearly demonstrated significant anticancer effects of plant foods (chlorella, fruit peels, oregano) containing mixtures of different phytochemicals manifesting comprehensive mechanism of action in the model of NMU‐induced mammary carcinogenesis in rats . Chemopreventive effects of plant foods, concretely rosemary, soya, blueberry and black raspberry in rat mammary carcinogenesis were found also by other authors .…”

“…Lower expression of CD24, CD44, ALDH1 and EpCAM is linked with better prognosis of breast carcinoma in patients . Our recent study showed decrease in CD24 and EpCAM expression in mammary cancer cells in rats after oregano treatment . Results of this experiment demonstrated decrease in CD24 and CD44 expressions in carcinomas, on the other hand increase in ALDH1 after treatment with CLOs.…”

“…However, both used dietary administered doses were well tolerated by animals. Doses of CLOs used in this study were based on our earlier experience with NMU‐induced rat mammary carcinoma model, where various plant‐derived functional foods were used, for example Chlorella pyrenoidosa , fruit peels or oregano .…”

Pharmacological and Phytochemical Studies of Origanum Vulgare: A Review

“…Origanum orally administration at the dose of (3 and 30 g/kg). According to results, tumoursuppressive effect of oregano in the breast cancer model has been observed for the first time [38].…”