Order Effects in Neuropsychological Investigations Utilizing Serial Regional Cerebral Blood Flow Measurements

Abstract

Neuropsychological investigations utilizing serial regional cerebral blood flow (rCBF) measurements have been inconsistent in their finding of run order effects. This study investigated the significance of run order when utilizing extended rCBF intermeasure intervals. Subjects were 20 healthy adult female volunteers. The 133-xenon inhalation technique was utilized in obtaining two rCBF measurements per subject. The mean intermeasure interval was 14.7hS.6 days. All measurements were performed during morning hours under conditions of minimal external sensory stimulation. No significant run order effect was obtained. Results are compared with relevant previous studies. Effect of intermeasure interval length on subject anxiety, habituation, fatigue, and on order effects are discussed.Int J Neurosci Downloaded from informahealthcare.com by University of Newcastle Upon Tyne on 12/20/14For personal use only.