Orally given indomethacin and blood flow response to UVL

Greenberg, Richard A.

doi:10.1001/archderm.111.3.328

Cited by 8 publications

(6 citation statements)

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“…These findings con firm some of the results of others [1][2][3][4][5][6][7][8][9][10][11][12]. IN has been reported to reduce the hyperemia after dosing with UVB (12]. Our findings also indicate that by 8-12 h after UVB the combination of an NSAID plus a topical corticosteroid provide the greatest reduction in SBF.…”

Section: Discussionsupporting

confidence: 92%

“…The therapy of the cutaneous response to ultravioletinduced injury is felt to be amenable to therapy with either topical [1][2][3][4][5][6][7][8][9] or oral [1,8,[10][11][12] nonsteroidal anti-inflam matory drugs (NSAIDs) and/or topical corticosteroids [1. 6.9].…”

mentioning

confidence: 99%

“…such as aspirin, ibuprofen (IB) or indo methacin (IN) inhibit the production of prostaglandins (especially of the E series) within the first 24 h after injury, whereas corticosteroids inhibit leukocyte migration or Previous investigations have focused on cither the oral or topical administration of NSAIDs and/or topical cortico steroids hut with mixed results [1][2][3][4][5][6][7][8][9][10][11][12]. Several studies which have used oral doses of aspirin ( 1,200 mg) [ 10,111, IB (400 mg) [II] or IN (25 mg) ( 12] before and after expo sure to UVB have given the best results in reduction of ery thema or SBF [12]. These studies indicated that NSAIDs were most effective when given early (or even prior to exposure to UVB or after solar injury) and contin ued for 24 h. The addition of potent topical corticosteroids provided additional benefit 24 h after injury in these stud ies.…”

mentioning

confidence: 99%

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Synergistic Effects of Oral Nonsteroidal Drugs and Topical Corticosteroids in the Therapy of Sunburn in Humans

et al. 1992

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The ability to modify skin injury due to ultraviolet light (UVB) by the nonsteroidal anti-inflammatory drugs (NSAIDs) oral ibuprofen (IB) or indomethacin (IN) plus topical betamethasone dipropionate (BD) was studied in 24 subjects in this open-label, four-way, cross-over trial. All subjects received UVB at weekly intervals: group 1 was randomized to IBBD, IB + BD or control, and group 2 to IN, BD, IN + BD or control. Oral medications were given prior to and after exposure to UVB, but BD was applied only afterwards. The skin response to UVB [erythema and increased skin blood flow (SBF)] was measured serially for 96 h. A skin biopsy was taken at 24 h after each dosing with UVB. At maximum erythema (8–12 h after UVB), the following approximate reductions in SBF (compared to control responses) were noted: 42–58% for combination therapies, 33–40% for IB or IN alone, and 17% for BD alone. SBF tended to equalize across all treatments by 24 h and remained until 96 h. Skin biopsy results were consistent with the noninvasive findings. Thus, we observed a synergistic effect of reduction of UVB-induced erythema and SBF with combinations of oral NSAIDs and topical corticosteroids. This study could have implications for the therapy of sunburn in humans.

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Section: Discussionsupporting

confidence: 92%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Synergistic Effects of Oral Nonsteroidal Drugs and Topical Corticosteroids in the Therapy of Sunburn in Humans

et al. 1992

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“…Indomethacin significantly reduced this in crease at 2 3 hr after irradiation. This result is essentially similar to the results reported in humans (34,35), except for the difference in the time when the diminishing effect of indomethacin was observed, probably due to the differ ence in the time course of erythemal response between the species. It was shown in the present study that the time courses of blood flow change agreed well with those of C* change in both control and indomethacin-administered animals.…”

Section: Discussionsupporting

confidence: 90%

Streptozocin-Diabetes Modifies Acetylcholine Release from Mouse Phrenic Nerve Terminal and Presynaptic Sensitivity to Succinylcholine

Nose

Tsurumi

1993

Japanese Journal of Pharmacology

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ABSTRACT-This study was conducted to quantify the intensity of ultraviolet (UV) erythema in guinea pigs, a method for evaluating anti-inflammatory drugs, and to clarify any correlation of erythema with cutaneous blood flow. Skin color and cutaneous blood flow in non-administered and indomethacin administered animals were measured by a colorimeter and a laser Doppler flowmeter over time after UV irradiation treatment. Skin color was indicated by a XYZ colorimetric system and L*a*b* color space. In either colorimetric system, the values of two indices, x and y or a* and b*, increased along with the inten sification of erythema. The increase in the chroma (C*) value calculated from a* and b* was UV-dose dependent. This value was significantly suppressed by indomethacin 0.5-4 hr after irradiation, and it was found to be a clear and sensitive index for evaluating the suppressive effect of drugs. Cutaneous blood flow also increased with UV irradiation. Indomethacin significantly suppressed this increase 2-3 hr after UV ir radiation. The changes of cutaneous blood flow correlated with those of C*. These results suggested C* was a suitable parameter to quantify UV erythema, and the change of skin color in UV erythema reflected the change of cutaneous blood flow.

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“…Prostaglandin synthetase inhibitors have previously been shown to inhibit the erythema resulting from u.v. irradiation (Snyder & Eaglstein, 1974a, b;Miller, Ruderman & Smith, 1967) and prostaglandins have previously been suggested to mediate this erythema (Greenberg, Eaglstein, Turnier & Houdek, 1975).…”

Section: Discussionmentioning

confidence: 98%

The effects of indomethacin on arachidonic acid and prostaglandins e2 and f2alpha levels in human skin 24 h after u.v.B and u.v.C irradiation.

Black¹,

Greaves²,

Hensby³

et al. 1978

Brit J Clinical Pharma

100

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1 Clinically normal human abdominal skin was irradiated with either three times its minimal erythema dose (MED) of ultraviolet B (u.v.B) or six MEDs of ultraviolet C (u.v.C) radiation. In both instances erythema was maximal at 24 h. 2 Exudate was recovered by a suction bulla technique from normal and irradiated skin at 24 h after irradiation. 3 Arachidonic acid, prostaglandins E2 and FSalpha, as measured by GC–MS, were significantly elevated at 24 h. Radioimmunoassay also showed increased PGF2alpha‐like concentrations. 4 Oral indomethacin only partially reduced the erythema resulting from both types of radiation but totally suppressed the elevation of PGE 2 and F2alpha concentrations. 5 Topical indomethacin also suppressed u.v.B‐induced increases in prostaglandins E2 and F2alpha. Unexpectedly, the vehicle alone produced a similar suppressive effect on prostaglandins although erythema appeared unaltered. 6 Most of the arachidonic acid metabolized by indomethacin‐sensitive pathways is not converted to prostaglandins E2 and F2alpha in human skin.

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Orally given indomethacin and blood flow response to UVL

Cited by 8 publications

References 0 publications

Synergistic Effects of Oral Nonsteroidal Drugs and Topical Corticosteroids in the Therapy of Sunburn in Humans

Synergistic Effects of Oral Nonsteroidal Drugs and Topical Corticosteroids in the Therapy of Sunburn in Humans

Streptozocin-Diabetes Modifies Acetylcholine Release from Mouse Phrenic Nerve Terminal and Presynaptic Sensitivity to Succinylcholine

The effects of indomethacin on arachidonic acid and prostaglandins e2 and f2alpha levels in human skin 24 h after u.v.B and u.v.C irradiation.

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