Orally administrated nucleotide-delivery particles from microfluidics for inflammatory bowel disease treatment

Gan, Jingjing; Liu, Yu-Xiao; Sun, Lingyu; Ma, Wenjuan; Chen, Guopu; Zhao, Cheng; Wen, Lihui; Zhao, Yuanjin; Sun, Lingyun

doi:10.1016/j.apmt.2021.101231

Cited by 13 publications

(11 citation statements)

References 38 publications

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“…Polysaccharides participate in many biological activities, such as cytoskeleton formation, energy metabolism, blood glucose regulation and immunity modulation, are biocompatible and biodegradable, and can be easily extracted, processed and modified. Polysaccharides extracted from plants (for example, alginate 105,106 , cellulose 107 , starch 108 , carrageenan 109 , pectin 110 , guar gum 109 , mannan 111 , glucomannan 112 and inulin 113 ), animals (for example, chitosan 101,114 , hyaluronate 5 and chondroitin sulfate 115 ) and microbes (for example, pullulan 116 and β-glucan 117 ) are being explored for oral drug delivery. Polysaccharide nanoparticle formulations can orally deliver small molecules, oligonucleotides, peptides and proteins 94 .…”

Section: Biological Materialsmentioning

confidence: 99%

“…Furthermore, proteins and peptides can form complexes or composites with other materials, such as metals and metal oxides 122 , polysaccharides 123 , and synthetic polymers 124 , through chemical reactions or gelation induced by changes in temperature, pH, or salt concentrations. Moreover, proteins and peptides can be modified to form or functionalize microparticles and nanoparticles; for example, methacrylated gelatin was polymerized by photocrosslinking to fabricate oral delivery particles 112 . Genetically engineered silk sericin nanospheres, which remained negatively charged in the intestine, were used for targeted delivery to positively charged proteins at inflammatory sites of the colon in a mouse model of ulcerative colitis 121 .…”

Section: Biological Materialsmentioning

confidence: 99%

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Bioinspired oral delivery devices

et al. 2023

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Oral administration is a widespread and convenient drug delivery approach. However, oral delivery can be affected by the complex digestive tract environment, including irregular tissue morphology, the presence of digestive enzymes, mucus and mucosal barriers, and spatiotemporal variance in physiological parameters. These obstacles can prevent the oral delivery of many therapeutics. To overcome these challenges, oral delivery devices can be designed with bioinspired compositions, structures or functions to make more drugs available for oral administration. Various bioinspired oral delivery devices have been developed by harnessing biological materials and living microorganisms, or by imitating biological structures and functions. In this Review, we discuss the design and modification of bioinspired oral delivery devices, examining engineering strategies to target specific tissues and applications. We highlight how key bottlenecks in oral delivery can be addressed through bioinspired designs, concluding with an outlook on the remaining challenges towards the clinical translation of bioinspired oral delivery devices. SectionsIntroduction Naturally derived oral delivery devices Bioinspired oral delivery Target tissues Outlook

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Section: Biological Materialsmentioning

confidence: 99%

Section: Biological Materialsmentioning

confidence: 99%

Bioinspired oral delivery devices

et al. 2023

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“…Furthermore, investigations of chemical syntheses in various microreactors configurations may also represent an important base for designing chips for other purposes. Specifically, fluid dynamics analyses may be of good use for researchers aiming to fabricate microfluidic platforms for emerging biomedical applications, including non-invasive diagnosis devices [ 108 , 109 , 110 , 111 , 112 ], cell culture media (organs-on-a-chip) [ 113 , 114 , 115 , 116 , 117 ], and precise drug-delivery systems [ 118 , 119 , 120 , 121 ].…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

A Review of Microfluidic Experimental Designs for Nanoparticle Synthesis

Niculescu

Mihăiescu

Grumezescu

2022

IJMS

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Microfluidics is defined as emerging science and technology based on precisely manipulating fluids through miniaturized devices with micro-scale channels and chambers. Such microfluidic systems can be used for numerous applications, including reactions, separations, or detection of various compounds. Therefore, due to their potential as microreactors, a particular research focus was noted in exploring various microchannel configurations for on-chip chemical syntheses of materials with tailored properties. Given the significant number of studies in the field, this paper aims to review the recently developed microfluidic devices based on their geometry particularities, starting from a brief presentation of nanoparticle synthesis and mixing within microchannels, further moving to a more detailed discussion of different chip configurations with potential use in nanomaterial fabrication.

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“…employed microfluidics to fabricate colon-targeted microparticles for the oral delivery of ASOs against tumor necrosis factor alpha (TNF-α). The cationic Konjac glucomannan developed and gelatin methacryloyl microparticles loaded with ASO nanocomplex were coated by the acid resistant Eudragit FS30D shells which can prevent release of the encapsulated drugs in the stomach or small intestine and enhancing their accumulation in colon selectively [ 31 ]. The glucomannan provided specific mannose ligands for targeting the macrophages and oral delivery of the ASOs resulted in reduced TNF-α expression in the colonic macrophages, thus reducing the inflammatory responses.…”

Section: Prospects Of the Oral Delivery Of Nucleic Acidsmentioning

confidence: 99%

Oral Delivery of Nucleic Acid Therapies for Local and Systemic Action

et al. 2022

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Nucleic acid (NA) therapy has gained importance over the past decade due to its high degree of selectivity and minimal toxic effects over conventional drugs. Currently, intravenous (IV) or intramuscular (IM) formulations constitute majority of the marketed formulations containing nucleic acids. However, oral administration is traditionally preferred due to ease of administration as well as higher patient compliance. To leverage the benefits of oral delivery for NA therapy, the NA of interest must be delivered to the target site avoiding all degrading and inhibiting factors during its transition through the gastrointestinal tract. The oral route presents myriad of challenges to NA delivery, making formulation development challenging. Researchers in the last few decades have formulated various delivery systems to overcome such challenges and several reviews summarize and discuss these strategies in detail. However, there is a need to differentiate between the approaches based on target so that in future, delivery strategies can be developed according to the goal of the study and for efficient delivery to the desired site. The goal of this review is to summarize the mechanisms for target specific delivery, list and discuss the formulation strategies used for oral delivery of NA therapies and delineate the similarities and differences between local and systemic targeting oral delivery systems and current challenges.

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Orally administrated nucleotide-delivery particles from microfluidics for inflammatory bowel disease treatment

Cited by 13 publications

References 38 publications

Bioinspired oral delivery devices

Bioinspired oral delivery devices

A Review of Microfluidic Experimental Designs for Nanoparticle Synthesis

Oral Delivery of Nucleic Acid Therapies for Local and Systemic Action

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