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Cited by 9 publications
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References 27 publications
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“…Although indirect, it can be of importance to discuss the reduced liver triglycerides in association with activation of peroxisome proliferator-activated receptor alpha (PPARα), a ligand-activated transcription factor involved in regulation of genes that stimulate removal of triglycerides from the bloodstream and enhance β-oxidation in the liver. Tributyrin, a similar sibling of monobutyrin, has been shown to increase mRNA and protein expression of PPARα, and β-oxidation related genes in rat liver [33]. These effects were mediated by increased acetylation of histone H3 in the liver, subsequently leading to inhibition of inflammatory markers and liver injury, and reduced levels of plasma triglycerides, total and LDL-cholesterol after 24 h LPS challenge.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Although indirect, it can be of importance to discuss the reduced liver triglycerides in association with activation of peroxisome proliferator-activated receptor alpha (PPARα), a ligand-activated transcription factor involved in regulation of genes that stimulate removal of triglycerides from the bloodstream and enhance β-oxidation in the liver. Tributyrin, a similar sibling of monobutyrin, has been shown to increase mRNA and protein expression of PPARα, and β-oxidation related genes in rat liver [33]. These effects were mediated by increased acetylation of histone H3 in the liver, subsequently leading to inhibition of inflammatory markers and liver injury, and reduced levels of plasma triglycerides, total and LDL-cholesterol after 24 h LPS challenge.…”
Section: Discussionmentioning
confidence: 99%
“…A complete answer cannot be achieved with the design and aim of this study since it is not known whether the enzymatic hydrolysis of MB to butyric acid is complete or not. However, taking into account reported positive effects of MB and tributyrin on cecal microbiota composition, liver lipids, high-fat diet-induced inflammation, and gut barrier function [9,17,33,38], it can be suggested that mechanisms responsible for the effects of MB are possibly related to main functions of butyric acid, i.e., inhibition of histone deacetylase and regulation of receptor-mediated signaling. A summary of effects and mechanisms of MB is illustrated in Figure 6.…”
Section: Discussionmentioning
confidence: 99%
“…Ohhira et al (Ohhira et al, ) showed that injection of LPS transiently induced lipid accumulation in hepatocytes, especially around the portal vein of mice. Miyoshi et al () also found that LPS injection increased the plasma triacylglycerol (TAG) and total cholesterol (TC) levels at 24 h in rats. These observations highlighted that LPS leads to liver injury and lipid metabolism disorder (Affò et al, ; Zhang, Xu, et al, ).…”
Section: Introductionmentioning
confidence: 94%
“…On the other hand, recent study on Tributyrin also prove that it can reduce the cholesterol level. Makata et al [8] study the effect of oral consumption of Tributyrin toward the level of plasma triglyceride, total cholesterol and low-density lipoprotein cholesterol in rat. The clinical research shows that Tributyrin is important for health science area.…”
Section: Resultsmentioning
confidence: 99%