volume 8, issue 6, P1167-1183 2016
DOI: 10.18632/aging.100962
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Rachelle E. Kaplon, Sierra D. Hill, Nina Z. Bispham, Jessica R. Santos-Parker, Molly J. Nowlan, Laura L. Snyder, Michel Chonchol, Thomas J. LaRocca, Matthew B. McQueen, Douglas R. Seals

Abstract: We hypothesized that supplementation with trehalose, a disaccharide that reverses arterial aging in mice, would improve vascular function in middle-aged and older (MA/O) men and women. Thirty-two healthy adults aged 50-77 years consumed 100 g/day of trehalose (n=15) or maltose (n=17, isocaloric control) for 12 weeks (randomized, double-blind). In subjects with Δbody mass<2.3kg (5 lb.), resistance artery endothelial function, assessed by forearm blood flow to brachial artery infusion of acetylcholine (FBFACh), …

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