Oral, Tongue-Coating Microbiota, and Metabolic Disorders: A Novel Area of Interactive Research

Li, Yiwen; Cui, Jing; Liu, Yanfei; Chen, Ke-ji; Huang, Lusheng; Liu, Yue

doi:10.3389/fcvm.2021.730203

Cited by 35 publications

(41 citation statements)

References 112 publications

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“…However, the theory of oral focal infection has not received enough attention and theoretical support. With the advances of microbiome research, the association between oral microbes and a variety of human chronic diseases has been studied, including inflammatory bowel disease, 3 cancers, 4 cardiovascular diseases, 5 Alzheimer’s disease, 6 diabetes, 7 rheumatoid arthritis, 8 and preterm birth 9 (Fig. 1 ).…”

Section: Introductionmentioning

confidence: 99%

Oral microbiota in human systematic diseases

et al. 2022

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Oral bacteria directly affect the disease status of dental caries and periodontal diseases. The dynamic oral microbiota cooperates with the host to reflect the information and status of immunity and metabolism through two-way communication along the oral cavity and the systemic organs. The oral cavity is one of the most important interaction windows between the human body and the environment. The microenvironment at different sites in the oral cavity has different microbial compositions and is regulated by complex signaling, hosts, and external environmental factors. These processes may affect or reflect human health because certain health states seem to be related to the composition of oral bacteria, and the destruction of the microbial community is related to systemic diseases. In this review, we discussed emerging and exciting evidence of complex and important connections between the oral microbes and multiple human systemic diseases, and the possible contribution of the oral microorganisms to systemic diseases. This review aims to enhance the interest to oral microbes on the whole human body, and also improve clinician’s understanding of the role of oral microbes in systemic diseases. Microbial research in dentistry potentially enhances our knowledge of the pathogenic mechanisms of oral diseases, and at the same time, continuous advances in this frontier field may lead to a tangible impact on human health.

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Section: Introductionmentioning

confidence: 99%

Oral microbiota in human systematic diseases

et al. 2022

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“…Table 2 [96][97][98][99][100][101][102][103][104][105][106][107][108][109][110][111][112] illustrates examples of research into the relationship between taste, food choices, and eating. Other factors such as smell/odor detection, satiety, and addictions follow in subsequent tables.…”

Section: Who Behavioral Modification #1: Eat a Healthy Diet (In Spite Of The Microbiota-driven Sense Control)mentioning

confidence: 99%

“…What we get from food depends upon what we eat but also on what the microbes do as per extraction and metabolism of the food. Table 2 [ 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 ] illustrates examples of research into the relationship between taste, food choices, and eating. Other factors such as smell/odor detection, satiety, and addictions follow in subsequent tables.…”

Section: Who Behavioral Modification #1: Eat a Healthy Diet (In Spite Of The Microbiota-driven Sense Control)mentioning

confidence: 99%

Microbiome First Approaches to Rescue Public Health and Reduce Human Suffering

Dietert

2021

Biomedicines

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The is a sequential article to an initial review suggesting that Microbiome First medical approaches to human health and wellness could both aid the fight against noncommunicable diseases and conditions (NCDs) and help to usher in sustainable healthcare. This current review article specifically focuses on public health programs and initiatives and what has been termed by medical journals as a catastrophic record of recent failures. Included in the review is a discussion of the four priority behavioral modifications (food choices, cessation of two drugs of abuse, and exercise) advocated by the World Health Organization as the way to stop the ongoing NCD epidemic. The lack of public health focus on the majority of cells and genes in the human superorganism, the microbiome, is highlighted as is the “regulatory gap” failure to protect humans, particularly the young, from a series of mass population toxic exposures (e.g., asbestos, trichloroethylene, dioxin, polychlorinated biphenyls, triclosan, bisphenol A and other plasticizers, polyfluorinated compounds, herbicides, food emulsifiers, high fructose corn syrup, certain nanoparticles, endocrine disruptors, and obesogens). The combination of early life toxicity for the microbiome and connected human physiological systems (e.g., immune, neurological), plus a lack of attention to the importance of microbial rebiosis has facilitated rather than suppressed, the NCD epidemic. This review article concludes with a call to place the microbiome first and foremost in public health initiatives as a way to both rescue public health effectiveness and reduce the human suffering connected to comorbid NCDs.

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“…What we get from food depends upon what we eat but also on what the microbes do as per extraction and metabolism of the food. Table 2 [96][97][98][99][100][101][102][103][104][105][106][107][108][109][110][111][112] illustrates examples of research into the relationship between taste, food choices, and eating. Other factors such as smell/odor detection, satiety, and addictions follow in subsequent tables.…”

Section: Who Behavioral Modification #1: Eat a Healthy Diet -(In Spite Of The Microbiota-driven Sense-diet Cycle)mentioning

confidence: 99%

“…One interesting observation was that an oral pathobiont, Treponema, was detected most often in adults with dental problems and in obese youth. Li et al [100] discuss the tongue microbiome, its effect on taste receptors and the routes through which tongue microbiota dysbiosis can directly and indirectly promote obesity, diabetes and cardiovascular disease.…”

Section: Tastementioning

confidence: 99%

Microbiome First Approaches to Rescue Public Health and Reduce Human Suffering

Dietert¹

2021

Preprint

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The is a sequential article to an initial review suggesting that Microbiome First medical approaches to human health and wellness could both aid the fight against noncommunicable diseases and conditions (NCDs) and help to usher in sustainable healthcare. This current review article specifically focuses on public health programs and initiatives and what has been termed by medical journals as a catastrophic record of recent failures. Included in the review is a discussion of the four priority behavioral modifications (food choices, cessation of two drugs of abuse, and exercise) advocated by the World Health Organization as the way to stop the ongoing NCD epidemic. The lack of public health focus on the majority of cells and genes in the human superorganism, the microbiome, is highlighted as is the “regulatory gap” failure to protect humans, particularly the young, from a series of mass population toxic exposures (e.g., asbestos, trichloroethylene, dioxin, polychlorinated biphenyls, triclosan, bisphenol A and other plasticizers, polyfluorinated compounds, herbicides, food emulsifiers, high fructose corn syrup, certain nanoparticles, endocrine disruptors, obesogens). The combination of early life toxicity for the microbiome and connected human physiological systems (e.g., immune, neurological), plus a lack of attention to the importance of microbial rebiosis has facilitated rather than suppressed, the NCD epidemic. This review article concludes with a call to place the microbiome first and foremost in public health initiatives as a way to both rescue public health effectiveness and reduce the human suffering connected to co-morbid NCDs.

show abstract

Oral, Tongue-Coating Microbiota, and Metabolic Disorders: A Novel Area of Interactive Research

Cited by 35 publications

References 112 publications

Oral microbiota in human systematic diseases

Oral microbiota in human systematic diseases

Microbiome First Approaches to Rescue Public Health and Reduce Human Suffering

Microbiome First Approaches to Rescue Public Health and Reduce Human Suffering

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