Oral supplementation with fish oil reduces dryness and pruritus in the acetone-induced dry skin rat model

Barcelos, Raquel Cristine Silva; Mello-Sampayo, Cristina de; Antoniazzi, Caren Tatiane de David; Segat, Hecson Jesser; Silva, Henrique; Veit, Juliana Cristina; Piccolo, Jaqueline; Emanuelli, Tatiana; Bürger, Marilise Escobar; Silva‐Lima, Beatriz; Rodrigues, Luís Monteiro

doi:10.1016/j.jdermsci.2015.06.015

Cited by 30 publications

(23 citation statements)

References 55 publications

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“…Fish oil and the related fatty acids are reported to be useful for ameliorating dermatitis symptoms. Barcelos et al [84] demonstrated the reduction of cutaneous dryness and pruritus by oral supplementation of fish oil in rats. Dry skin is a consequence of the subtraction of epidermal water content due to stratum corneum barrier function loss [85].…”

Section: Fatty Acids For Skin Disorder Prevention and Treatmentmentioning

confidence: 99%

Cosmetic and Therapeutic Applications of Fish Oil’s Fatty Acids on the Skin

et al. 2018

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Fish oil has been broadly reported as a potential supplement to ameliorate the severity of some skin disorders such as photoaging, skin cancer, allergy, dermatitis, cutaneous wounds, and melanogenesis. There has been increasing interest in the relationship of fish oil with skin protection and homeostasis, especially with respect to the omega-3 polyunsaturated fatty acids (PUFAs), docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA). The other PUFAs, such as α-linolenic acid (ALA) and linoleic acid (LA), also show a beneficial effect on the skin. The major mechanisms of PUFAs for attenuating cutaneous inflammation are the competition with the inflammatory arachidonic acid and the inhibition of proinflammatory eicosanoid production. On the other hand, PUFAs in fish oil can be the regulators that affect the synthesis and activity of cytokines for promoting wound healing. A systemic review was conducted to demonstrate the association between fish oil supplementation and the benefits to the skin. The following describes the different cosmetic and therapeutic approaches using fatty acids derived from fish oil, especially ALA, LA, DHA, and EPA. This review summarizes the cutaneous application of fish oil and the related fatty acids in the cell-based, animal-based, and clinical models. The research data relating to fish oil treatment of skin disorders suggest a way forward for generating advances in cosmetic and dermatological uses.

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Section: Fatty Acids For Skin Disorder Prevention and Treatmentmentioning

confidence: 99%

Cosmetic and Therapeutic Applications of Fish Oil’s Fatty Acids on the Skin

et al. 2018

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“…Dry skin is apparent in several human pruritic diseases such as senile xerosis and pruritus in renal insufficiency . In a rodent model of dry skin pruritus, cutaneous barrier disruption is induced by repeated cutaneous application of an acetone–ether solution and water .…”

Section: Animal Models Of Itchmentioning

confidence: 99%

Preclinical and human surrogate models of itch

Hoeck

Marker

Gazerani

et al. 2016

Experimental Dermatology

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Pruritus, or simply itch, is a debilitating symptom that significantly decreases the quality of life in a wide range of clinical conditions. While histamine remains the most studied mediator of itch in humans, treatment options for chronic itch, in particular antihistamine-resistant itch, are limited. Relevant preclinical and human surrogate models of non-histaminergic itch are needed to accelerate the development of novel antipruritics and diagnostic tools. Advances in basic itch research have facilitated the development of diverse models of itch and associated dysaesthesiae. While experimental itch in humans is induced over a short period of time and usually assessed psychophysically, the study of itch reactions in animals allows for both short-term and long-term studies but relies heavily on behavioural assessments. This review provides a background and a presentation of the established models of itch currently applied in animals and humans with emphasis on translatability. K E Y W O R D Sanimal, histaminergic itch, non-histaminergic itch, pruritus, surrogate models, translational ineffective. Itch and pain are related but distinct sensations, and while pain has been extensively studied, the understanding of itch transmission is lacking behind. 6 There is evidence for different peripheral and central mechanisms underlying histaminergic and non-histaminergic itch, 3,7 and elucidation of the pathways and mechanisms mediating itch, especially chronic itch, is essential to the development of novel antipruritic drugs. In this regard, both preclinical and human surrogate models serve as important tools to expand the current knowledge. 3,8This review presents an overview of the currently available preclinical and human surrogate models of itch. | APPLICABILITY OF TRANSLATIONAL MODELSIdeal translational models of pruritus should induce itch through pathways associated with those involved in human pruritic diseases while closely mimicking one or several symptomatological aspects of these diseases.For example, itch in urticaria is well linked to mast cell degranulation and can be mimicked experimentally with histamine administration in both animal and human surrogate models. 9-13 The validity is confirmed by comparable efficacy of antihistamines between the animal models, the human surrogate models and the urticarial patient population. 10-13Translational models of itch can also provide a platform for screening compounds for antipruritic activity in a preclinical setting, evaluation of antipruritic drug candidates in phase Ib, and to mechanistically profile and select patients for phase II-III clinical trials.

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“…Barcelos et al . administered daily omega‐3 fish oils (FOs) to rats and observed the changes in dermal response to skin irritation after 30, 60 and 60 days of supplementation. After 60 days of supplementation, both irritation and TEWL were significantly reduced in response to acetone exposure.…”

Section: Moisturizing Moleculesmentioning

confidence: 99%

“…The SCPB reduces both transepidermal water loss (TEWL) and pathogenic invasion [160][161][162]; therefore, loss of lipid components may cause skin dryness [9,155,163]. Marine-derived lipids can aid in preserving skin hydration by maintaining the lipid matrix of the SC [163,164]. Omega-3 oils, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), can be easily extracted from several marine and freshwater fish [165][166][167], which are naturally enriched in EPA and DHA.…”

Section: Moisturizing Moleculesmentioning

confidence: 99%

The promise of marine molecules as cosmetic active ingredients

Brunt

Burgess

2017

Intern J of Cosmetic Sci

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The marine environment represents an underexploited resource for the discovery of novel products, despite its high level of biological and chemical diversity. With increasing awareness of the harmful effects of chronic ultraviolet exposure, and a universal desire to improve cosmetic appearance, the market for new cosmetic ingredients is growing, and current trends have generated a greater demand for products sourced from the environment. A growing number of novel molecules from marine flora and fauna exhibit potent and effective dermatological activities. Secondary metabolites isolated from macroalgae, including carotenoids and polyphenols, have demonstrated antioxidant, anti-ageing and anti-inflammatory activities. In addition, marine extremophilic bacteria have recently been shown to produce bioactive exopolymeric molecules, some of which have been commercialized. Available data on their activities show significant antioxidant, moisturizing and anti-ageing activities, but a more focussed investigation into their mechanisms and applications is required. This review surveys the reported biological activities of an emerging and growing portfolio of marine molecules that show promise in the treatment of cosmetic skin problems including ultraviolet damage, ageing and cutaneous dryness.R esum e L'environnement marin repr esente une ressource sous-exploit ee pour la d ecouverte de nouveaux produits, malgr e son niveau elev e de diversit e biologique et chimique. Avec la prise de conscience croissante des effets n efastes de l'exposition chronique aux ultraviolets et un d esir universel d'am eliorer l'apparence, le march e des nouveaux ingr edients cosm etiques est en croissance et les tendances actuelles ont g en er e une plus grande demande pour les produits issus de l'environnement. Un nombre croissant de nouvelles mol ecules issues de la flore et de la faune marines pr esentent des activit es dermatologiques efficaces et performantes. Les m etabolites secondaires isol es des macroalgues, y compris les carot eno€ ıdes et les polyph enols, ont d emontr e des activit es antioxydantes, antivieillissement et anti-inflammatoires. De plus, il a et e d emontr e r ecemment que les bact eries extrêmophiles marines produisent des mol ecules exopolym eriques bioactives, dont certaines ont et e commercialis ees. Les donn ees disponibles sur leurs activit es montrent des activit es antioxydantes, hydratantes et anti-ages significatives, mais une investigation plus cibl ee de leurs m ecanismes et applications est requise. Cette revue etudie les activit es biologiques rapport ees d'une gamme emergente et croissante de mol ecules marines prometteuses, dans le traitement des probl emes de peau cosm etiques, y compris les dommages caus es par les ultraviolets, le vieillissement et la s echeresse cutan ee.

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Oral supplementation with fish oil reduces dryness and pruritus in the acetone-induced dry skin rat model

Cited by 30 publications

References 55 publications

Cosmetic and Therapeutic Applications of Fish Oil’s Fatty Acids on the Skin

Cosmetic and Therapeutic Applications of Fish Oil’s Fatty Acids on the Skin

Preclinical and human surrogate models of itch

The promise of marine molecules as cosmetic active ingredients

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