ORAL SQUAMOUS CELL CARCINOMA IN AN AGED CAPTIVE WHITE RHINOCEROS (<i>CERATOTHERIUM SIMUM</i>)

Langer, Sandra; Czerwonka, Nadine; Ternes, Kerstin; Herbst, Werner; Koehler, Kernt

doi:10.1638/2015-0238.1

Cited by 5 publications

(3 citation statements)

References 7 publications

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“…In megavertebrates, oral and facial proliferative lesions have been previously reported. This includes cases of gingivitis, tooth root abscessation, and SCC [31][32][33]. It is important to conduct routine clinical examinations and detailed histopathological examinations to properly diagnose these lesions.…”

Section: Discussionmentioning

confidence: 99%

Dentinogenic Ghost Cell Tumor in a Sumatran Rhinoceros

Salleh

Zainuddin

Tarmizi

et al. 2021

Animals

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An adult female Sumatran rhinoceros was observed with a swelling in the left infraorbital region in March 2017. The swelling rapidly grew into a mass. A radiograph revealed a cystic radiolucent area in the left maxilla. In June 2017, the rhinoceros was euthanized. At necropsy, the infraorbital mass measured 21 cm × 30 cm. Samples of the infraorbital mass, left parotid gland, and left masseter muscle were collected for histopathology (Hematoxylin & Eosin, Von Kossa, Masson’s trichrome, cytokeratin AE1/AE3, EMA, p53, and S-100). Numerous neoplastic epithelial cells showing pleomorphism and infiltration were observed. Islands of dentinoid material containing ghost cells and keratin pearls were observed with the aid of the two special histochemistry stains. Mitotic figures were rarely observed. All the neoplastic odontogenic cells and keratin pearls showed an intense positive stain for cytokeratin AE1/AE3, while some keratin pearls showed mild positive stains for S-100. All samples were negative for p53 and S-100 immunodetection. The mass was diagnosed as a dentinogenic ghost cell tumor.

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Section: Discussionmentioning

confidence: 99%

Dentinogenic Ghost Cell Tumor in a Sumatran Rhinoceros

Salleh

Zainuddin

Tarmizi

et al. 2021

Animals

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“…In humans it represents 95% of oral neoplasms, and it is associated with alcohol and tobacco consumption, low hygiene, inadequate diets, and papillomavirus infection (10). Oral SCC has been described in other species of wild ungulates including white rhinoceros (Ceratotherium simum) (5) and Malayan tapir (Tapirus indicus) (8). In both cases, etiology was not established and the possibility of a viral infection predisposing to neoplastic development was not ruled out.…”

Section: Discussionmentioning

confidence: 99%

Metastatic oral squamous cell carcinoma in a captive common hippopotamus (Hippopotamus amphibius)

Oliveira¹,

Arenales²,

Carvalho³

et al. 2018

BJVP

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Oliveira, et al.; Metastatic oral squamous cell carcinoma in a captive common hippopotamus (Hippopotamus amphibius). Braz J Vet Pathol, 2018, 11(2), 64 -67. DOI: 10.24070/bjvp.1983 AbstractReported cases of neoplasia affecting hippopotamus are very scarce. This report describes a metastatic oral squamous cell carcinoma in a captive 44-year-old male common hippopotamus (Hippopotamus amphibius) that developed progressive loss of appetite, fibrinohemorrhagic oral discharge, and progressive weight loss. Gross, cytological, and histopathological findings were compatible with a conclusive diagnosis of an invasive oral squamous cell carcinoma with metastasis in the lung, adrenal, and spleen. To the best of our knowledge this is the first report of squamous cell carcinoma in a common hippopotamus.

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“…Traumatic damage primarily involves a physical injury of sudden onset, such as tooth fractures during combat (Garutt, 1997;Miles & Grigson, 2003). Secondarily, it may result in subsequent defects, such as root resorption, or chronic infections, such as periodontitis (chronic inflammation of the gum tissue) (Trope, 2002;Miles & Grigson, 2003;Shaddox & Walker, 2010;Langer et al, 2016). Non-traumatic damage includes congenital defects, such as supernumerary teeth, enamel hypoplasia or acquired tooth defects, such as dental caries (Miles & Grigson, 2003;Touger-Decker & van Loveren, 2003;Koenigswald et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Dental paleopathology in fossil rhinoceroses: etiology and implications

Rößner

2017

Journal of Zoology

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The identification and interpretation of paleopathological findings in the dentition of mammals have the potential to shed light on disturbed development and stress conditions. In combination with knowledge about the timing of dental development, dental pathologies can provide a unique opportunity to reconstruct specific phases in the life history of fossil taxa, as well as animal-environment interactions. The dental ontogeny of the extinct rhinoceros Prosantorhinus germanicus from the Miocene is well-known from an exceptionally preserved sample of juvenile dentaries. Two of the represented juvenile individuals each revealed a dental anomaly, which were analyzed macroscopically and via X-ray tomography in this study. One specimen documents decreased dental wear of deciduous cheek teeth, mandibular bone resorption as well as abnormal cemental deposition. At an early age, the extinct juvenile rhinoceros probably was affected by a gingival infection resulting from an accumulation of bacterial plaque. This led to a chronic gingivitis and eventually may have caused periodontitis. Furthermore, it suffered from inflammation-induced hypercementosis. Another specimen revealed an abnormal reduction in thickness of enamel in the deciduous cheek tooth. The enamel hypoplasia indicates stress experienced during the prenatal period. During a phase of environmental stress (e.g. increased fluoride exposure) or physiological stress (e.g. malnutrition) the function of the secretory ameloblasts was disrupted in the developing embryo. The present work shows that the analysis of dental paleopathologies is a useful means for retrospective assessment of specific phases in the life history of extinct animals. This adds to the picture of the living conditions of the extinct rhinoceros P. germanicus.

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ORAL SQUAMOUS CELL CARCINOMA IN AN AGED CAPTIVE WHITE RHINOCEROS (CERATOTHERIUM SIMUM)

Cited by 5 publications

References 7 publications

Dentinogenic Ghost Cell Tumor in a Sumatran Rhinoceros

Dentinogenic Ghost Cell Tumor in a Sumatran Rhinoceros

Metastatic oral squamous cell carcinoma in a captive common hippopotamus (Hippopotamus amphibius)

Dental paleopathology in fossil rhinoceroses: etiology and implications

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