Oral Sildenafil Citrate (Viagra) for Erectile Dysfunction: A Systematic Review and Meta-analysis of Harms

Sildenafil Alleviates Bronchopulmonary Dysplasia in Neonatal Rats by Activating the Hypoxia-Inducible Factor Signaling Pathway

“…Sildenafil was originally developed to treat male erectile dysfunction (47). Sildenafil binds and inactivates PDE5, leading to an elevation of cGMP in penile smooth muscle cells.…”

Mechanisms of Penile Erection and Basis for Pharmacological Treatment of Erectile Dysfunction

“…Sildenafil. The efficacy of sildenafil when taken on demand at doses of 25, 50, and 100 mg has been well documented in numerous reviews (Hatzimouratidis, 2006;Giuliano et al, 2010;Tsertsvadze et al, 2009;Eardley et al, 2010 and references therein). It is also clear that sildenafil is efficacious in men where the ED is a consequence of specific diseases such as diabetes, depression, spinal cord injury, multiple sclerosis, CV disease, and hypertension.…”

“…It is also clear that sildenafil is efficacious in men where the ED is a consequence of specific diseases such as diabetes, depression, spinal cord injury, multiple sclerosis, CV disease, and hypertension. It is effective in men with lower urinary tract symptoms and ED (Tsertsvadze et al, 2009;Eardley et al, 2010;Giuliano et al, 2010). Side effects do occur with sildenafil (most notably headache, flushing, indigestion, nasal congestion, and occasional visual changes), but providing that the drug is used in line with the labeling recommendations, there is no convincing evidence in the literature of any significant safety issue, including CV, visual, and aural safety (Tsertsvadze et al, 2009;Eardley et al, 2010;Giuliano et al, 2010).…”

Current Perspectives on Pharmacotherapy Treatments for Erectile Dysfunction

“…Minor side effects do occur with the use of sildenafil; the most reported side effects were headaches, flushing, indigestion, and visual changes [9,19,22]. Sildenafil will most likely continue to be the drug of choice for physicians, since there have not been any reports that have cast uncertainty on its safety for men with ED.…”