Oral Reduced L‐Glutathione Improves Growth in Pediatric Cystic Fibrosis Patients

Visca, A; Bishop, Clark T.; Hilton, Sterling C.; Hudson, Valerie M.

doi:10.1097/mpg.0000000000000738

Cited by 20 publications

(17 citation statements)

References 32 publications

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“…We postulate that it may be related to their antioxidant properties, assuming the increased GSH observed in testicular tissues reflects a systemic increase in reduced GSH. For reasons that are not fully understood, administration of reduced GSH is known to promote weight gain in humans receiving cisplatin (Smyth et al., ), as well as in other conditions characterised by weight loss, such as cystic fibrosis (Visca, Bishop, Hilton, & Hudson, ). Further studies are needed to determine the effects of different doses of montelukast on systemic GSH status, energy balance and food consumption in cisplatin‐treated rats.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of melatonin versus montelukast in cisplatin-induced seminiferous tubule damage in rats

et al. 2018

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We compared the protective effects of melatonin and montelukast against cisplatin-induced testicular damage. Adult male rats were assigned to one of four groups: a control group, a cisplatin (Cis) group treated with a single intraperitoneal injection of 7 mg/kg cisplatin, a cisplatin + melatonin group (Cis-Mel) and a cisplatin + montelukast group (Cis-Mon) each treated with the same dose of cisplatin together with either oral melatonin (20 mg/kg) or oral montelukast (10 mg/kg) in 2 ml water from day 1 to day 10 starting on the day of the cisplatin injection. Cisplatin-induced oxidative stress, with a significant increase in testicular malonedialdehyde (MDA), decreased testicular glutathione (GSH), histological testicular damage and body weight loss. Additionally, increased abnormal sperm forms and decreased count and motility were noted. Melatonin and montelukast both rescued GSH concentrations, increased sperm count and motility and decreased abnormal forms. Montelukast resulted in better rescue of weight loss, while greater improvement in sperm count and testicular pathology, and a trend for decreased MDA were noted with melatonin. These findings suggest that melatonin and montelukast protect against different aspects of cisplatin-induced toxicity. Future studies should assess whether both drugs may have additive benefit when used in combination.

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Section: Discussionmentioning

confidence: 99%

Protective effect of melatonin versus montelukast in cisplatin-induced seminiferous tubule damage in rats

et al. 2018

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“…Intestinal inflammation in CF may have significant clinical relevance due to its link with growth and nutrition [9,13,14]. In children with CF compared to healthy controls (HC), intestinal bacterial profiles are often characterised by an increased abundance of Proteobacteria (Escherichia coli, Shigella, Enterobacter) and a decreased abundance of Bacteroidetes (Bacteroides, Alistipes) and Firmicutes (Faecalibacterium prausnitzii) [4,6,8,12].…”

Section: Introductionmentioning

confidence: 99%

The intestinal virome in children with cystic fibrosis differs from healthy controls

et al. 2020

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Intestinal bacterial dysbiosis is evident in children with cystic fibrosis (CF) and intestinal viruses may be contributory, given their influence on bacterial species diversity and biochemical cycles. We performed a prospective, case-control study on children with CF and age and gender matched healthy controls (HC), to investigate the composition and function of intestinal viral communities. Stool samples were enriched for viral DNA and RNA by viral extraction, random amplification and purification before sequencing (Illumina MiSeq). Taxonomic assignment of viruses was performed using Vipie. Functional annotation was performed using Virsorter. Inflammation was measured by calprotectin and M2-pyruvate kinase (M2-PK). Eight CF and eight HC subjects were included (50% male, mean age 6.9 ± 3.0 and 6.4 ± 5.3 years, respectively, p = 0.8). All CF subjects were pancreatic insufficient. Regarding the intestinal virome, no difference in Shannon index between CF and HC was identified. Taxonomy-based beta-diversity (presence-absence Bray-Curtis dissimilarity) was significantly different between CF and HC (R 2 = 0.12, p = 0.001). Myoviridae, Faecalibacterium phage FP Taranis and unclassified Gokushovirinae were significantly decreased in CF compared with HC (q<0.05). In children with CF (compared to HC), the relative abundance of genes annotated to (i) a peptidoglycan-binding domain of the peptidoglycan hydrolases (COG3409) was significantly increased (q<0.05) and (ii) capsid protein (F protein) (PF02305.16) was significantly decreased (q<0.05). Picornavirales, Picornaviridae, and Enterovirus were found to positively correlate with weight and BMI (r = 0.84, q = 0.01). Single-stranded DNA viruses negatively correlated with M2-PK (r =-0.86, q = 0.048). Children with CF have an altered intestinal virome compared to well-matched HC, with both taxonomic and predicted functional changes. Further exploration of Faecalibacterium phages, Gokushovirinae and phage lysins are warranted. Intestinal viruses and their functions may

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“…Capsules containing 500 mg L-glutathione or 300mg L-glutathione plus curcumin, as a possible potentiator [43,44], are sold as natural supplements. Oral Lglutathione (Theranaturals, ID, USA) met primary and secondary endpoints in a placebo-controlled 6-month trial in CF children (NCT02029521), where it significantly improved growth and reduced gut inflammation [45]. In an uncontrolled study, CF patients using oral or inhaled L-glutathione appeared to have improved lung function and increased body weight [46].…”

Section: Reduced L-glutathionementioning

confidence: 99%

Current status of selected oral peptide technologies in advanced preclinical development and in clinical trials

Aguirre

Teijeiro‐Osorio

Rosa

et al. 2016

Advanced Drug Delivery Reviews

256

151

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Publication informationAdvanced Drug Delivery Reviews, 106 (Part B):Publisher Elsevier Item record/more information http://hdl.handle.net/10197/7801 Publisher's statementThis is the author's version of a work that was accepted for publication in Advanced Drug Delivery Reviews. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Advanced Drug Delivery Reviews (106, Part B, (2016)

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Oral Reduced L‐Glutathione Improves Growth in Pediatric Cystic Fibrosis Patients

Abstract: Oral reduced L-GSH significantly improves measures of growth status and gut inflammation in CF.

Cited by 20 publications

References 32 publications

Protective effect of melatonin versus montelukast in cisplatin-induced seminiferous tubule damage in rats

Protective effect of melatonin versus montelukast in cisplatin-induced seminiferous tubule damage in rats

The intestinal virome in children with cystic fibrosis differs from healthy controls

Current status of selected oral peptide technologies in advanced preclinical development and in clinical trials

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