Oral premalignant lesions: is a biopsy reliable?

Holmstrup, Palle; Vedtofte, Poul; Reibel, Jesper; Stoltze, Kaj

doi:10.1111/j.1600-0714.2007.00513.x

Cited by 151 publications

(119 citation statements)

References 27 publications

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“…We thus believe that the histopathological diagnosis reflects the true nature of the lesion. Holmstrup et al (19), in a retrospective study to learn whether an incisional biopsy of oral premalignant lesions, leukoplakia and erythroplakia, showed histopathological findings representative of the whole surgically removed lesion, observed underdiagnosis in 35% of the incisional biopsies, and stepwise sectioning revealed seven unexpected carcinomas (7%).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of cell proliferation rate in non-dysplastic leukoplakias

Hildebrand

Carrard²,

Lauxen³

et al. 2010

Med Oral

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http://www.medicinaoral.com/medoralfree01/v15i2/medoralv15i2p328.pdf AbstractObjective: Analyze whether the most frequent cases of non-dysplastic leukoplakias, hyperkeratosis (H), acanthosis (A), and hyperkeratosis with acanthosis (HA) have similar cell proliferation rates and to compare them with epithelial dysplastic (ED) leukoplakias and normal oral epithelium (NOE).Study design: The sample comprised 10 cases of normal oral epithelium, 10 cases of hyperkeratosis, 10 cases of acanthosis, 10 cases of hyperkeratosis with acanthosis and 10 cases of epithelial dysplasia. The mean number of AgNORs per nucleus (mAgNOR) and the mean percentage of cells with 1, 2, 3 and 4 or more AgNORs per nucleus (pAgNOR) were recorded. Results: The results of mAgNOR showed differences between disorders in the evaluation of the basal layer, of the parabasal layer, and in the overall evaluation. mAgNOR and pAgNOR=2 increased progressively from normal oral epithelium to hyperkeratosis with acanthosis, hyperkeratosis, acanthosis and epithelial dysplasia (p<0.05). Cell proliferation rate was different between different subtypes of non-dysplastic leukoplakias and this group presented a higher proliferative behavior when compared to normal oral epithelium. Conclusion: It may be suggested that non-dysplastic leukoplakias had different characteristics regarding cell proliferation rates and sometimes showed a proliferative behavior similar to that found in epithelial dysplasia. More studies should be conduced to increase knowledge about the biological profile of non-dysplastic leukoplakias, especially as it pertains to acanthosis.

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Section: Discussionmentioning

confidence: 99%

Evaluation of cell proliferation rate in non-dysplastic leukoplakias

Hildebrand

Carrard²,

Lauxen³

et al. 2010

Med Oral

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“…Some studies have shown that presence of Oral Epithelial Dysplasia (OED) in OPML as the most reliable factors predicting malignant transformation (Abbey et al, 1995). But there are other studies contradicting the presence of epithelial dysplasia in the biopsy not being a significant factor for malignant development (Holmstrup et al, 2007). Histopathological assessment many times is subjected to inter-observer variation.…”

Section: Introductionmentioning

confidence: 99%

p53 Expression Helps Identify High Risk Oral Tongue Premalignant Lesions and Correlates with Patterns of Invasive Tumour Front and Tumour Depth in Oral Tongue Squamous Cell Carcinoma Cases

Thangaraj

Shyamsundar²,

Ramani³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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Oral tongue squamous cell carcinoma (OTSCC) is the most common oral cancer subtype with a maximum propensity for regional spread. Our objective was to study if p53 expression might have any correlation with aggressive patterns of invasion within oral tongue cancers as well as with the histologically identified degree of oral tongue dysplasia. p53 immunoexpression was studied using immunohistochemistry in early staged OTSCCs (n=155), oral tongue dysplasias, (n=29) and oral tongue normal specimens (n=10) and evaluated for correlations with histological and clinicopathological parameters. Our study (n=194) showed a pattern of p53 expression increasing with different grades of tongue dysplasia to different grades of invasive OTSCC (p=0.000). Among the OTSCC tumours, positive p53 expression was seen in 43.2% (67/155) and a higher p53 labelling index was significantly associated with increased Bryne's grade of the tumour invasive front (p=0.039) and increased tumour depth (p=0.018). Among the OTSCC patients with tobacco habits, (n=91), a higher p53 labelling index was significantly associated with increased risk of local recurrence (p=0.025) and with lymphovascular space involvement (p=0.014). Evaluation of p53 through varying degrees of dysplasia to oral tongue cancer indicates that p53 expression is linked to aggressive features of oral tongue cancers and tongue precancers entailing a closer monitoring in positive cases. Among the OTSCCs, p53 expression is associated with tumour aggressiveness correlating with increased grading of invasive tumour front and tumour depth.

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“…Dans l'étude prospective, toutes les lésions ont bénéficié d'une analyse anatomopathologique à partir de biopsies réalisées avant la première consultation ou lors de celle-ci. Certains auteurs ont souligné que, concernant les lésions « pré-cancéreuses » de la muqueuse buccale, la biopsie localisée était insuffisante et que l'exérèse complète de la lésion et son étude anatomopathologique était nécessaire pour évaluer la présence et le grade de la dysplasie [15] . Ainsi, dans une étude portant sur 101 lésions « pré-cancéreuses » ou précurseurs du carcinome épi-dermoïde chez 96 patients, Holmstrup et coll.…”

Section: Biopsieunclassified

“…Ainsi, dans une étude portant sur 101 lésions « pré-cancéreuses » ou précurseurs du carcinome épi-dermoïde chez 96 patients, Holmstrup et coll. ont comparé les données histologiques de l'exérèse totale de la lésion réalisée en moyenne 10,4 mois après la biopsie [15] . Les résultats de l'étude montraient que 35 % des lésions avaient un degré de dysplasie plus sévère sur un endroit de la lésion qui n'a pas été intéressé par la biopsie initiale.…”

Section: Biopsieunclassified

Traitement des lésions blanches non détachables de la muqueuse buccale par laser CO₂: études rétrospective et prospective

Nuncques

Deparcy

Nawrocki

et al. 2008

Med Buccale Chir Buccale

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RÉSUMÉUne lésion blanche non détachable de la muqueuse buccale correspond le plus souvent à une kératose de surface. Pour ces lésions à risque de transformation, le traitement reste controversé. Pour évaluer l'efficacité du laser CO 2 , deux études ont été menées. La première, rétrospective, a porté sur 61 patients présentant 64 lésions traitées sur une période de 17 ans ; la seconde, prospective, a concerné 12 patients présentant 13 lésions, pendant un an. L'âge, le sexe, le praticien référent, le type et le site de la lésion, la présence de dysplasie, un facteur favorisant, la survenue d'une récidive ou d'une transformation maligne ont été recherchés. Le lichen plan touche davantage la femme, tandis que les lésions papillomateuses ou verruqueuses prédominent chez l'homme. Les lésions se situent préférentiellement sur la face interne des joues. Des facteurs favorisants ont été retrouvés (terrain dépressif, tabac, traumatisme, éléments métalliques). Le taux de récidive a été de 26,6 % dans l'étude rétrospective, celui de transformation maligne de 7,8 %. Dans l'étude prospective, ils ont été respectivement de 33,3 % et de 0% (pour la période d'observation). Compte-tenu de ces résultats et des facilités opératoires, et sous couvert d'une biopsie pré-opératoire, l'utilisation du laser CO 2 semble être une alternative intéressante aux autres techniques chirurgicales (excision, électrocoagulation, cryothérapie)

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Oral premalignant lesions: is a biopsy reliable?

Abstract: The estimated odds ratio showed that none of the associated variables including presence of any degree of epithelial dysplasia in the whole lesion, site, demarcation and smoking had influence on the risk of malignant development.

Cited by 151 publications

References 27 publications

Evaluation of cell proliferation rate in non-dysplastic leukoplakias

Evaluation of cell proliferation rate in non-dysplastic leukoplakias

p53 Expression Helps Identify High Risk Oral Tongue Premalignant Lesions and Correlates with Patterns of Invasive Tumour Front and Tumour Depth in Oral Tongue Squamous Cell Carcinoma Cases

Traitement des lésions blanches non détachables de la muqueuse buccale par laser CO₂: études rétrospective et prospective

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Oral premalignant lesions: is a biopsy reliable?

Abstract: The estimated odds ratio showed that none of the associated variables including presence of any degree of epithelial dysplasia in the whole lesion, site, demarcation and smoking had influence on the risk of malignant development.

Cited by 151 publications

References 27 publications

Evaluation of cell proliferation rate in non-dysplastic leukoplakias

Evaluation of cell proliferation rate in non-dysplastic leukoplakias

p53 Expression Helps Identify High Risk Oral Tongue Premalignant Lesions and Correlates with Patterns of Invasive Tumour Front and Tumour Depth in Oral Tongue Squamous Cell Carcinoma Cases

Traitement des lésions blanches non détachables de la muqueuse buccale par laser CO2: études rétrospective et prospective

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Traitement des lésions blanches non détachables de la muqueuse buccale par laser CO₂: études rétrospective et prospective