Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

2
36
0

Year Published

2012
2012
2021
2021

Publication Types

Select...
6
1
1

Relationship

1
7

Authors

Journals

citations
Cited by 99 publications
(38 citation statements)
references
References 28 publications
2
36
0
Order By: Relevance
“…Importantly, PLGA has been used in clinical devices, and low cytotoxicity of chitosanmodified PLGA NS was confirmed by several basic studies. 17 By entrapping them in the PLGA nano-matrix, decoy ODN were protected against enzymatic degeneration and obtained a controlled release profile in vivo. In addition, the positively charged chitosan allowed the absorption of anionic decoy ODN onto the particle surface by means of ionic interaction and inhibited leakage of decoy ODN from the nano-matrix before releasing ODN in the cytoplasm.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Importantly, PLGA has been used in clinical devices, and low cytotoxicity of chitosanmodified PLGA NS was confirmed by several basic studies. 17 By entrapping them in the PLGA nano-matrix, decoy ODN were protected against enzymatic degeneration and obtained a controlled release profile in vivo. In addition, the positively charged chitosan allowed the absorption of anionic decoy ODN onto the particle surface by means of ionic interaction and inhibited leakage of decoy ODN from the nano-matrix before releasing ODN in the cytoplasm.…”
Section: Discussionmentioning
confidence: 99%
“…Biocompatible PLGA NS were prepared by an emulsion solvent diffusion method, and the particle surface was modified with chitosan, as previously described. 16,17 Using this preparation method, decoy ODN could be loaded on both the inner and outer layer of chitosan-modified PLGA NS. In this study, we used 3 types of NFκB decoy ODN-loaded chitosan-modified PLGA NS (NFκB-NS; Figure 1A): encapsulated type (ODN were entrapped in NS only), surface-supported type (ODN were bound to NS surface only), and encapsulated/surface-supported type (ODN were loaded both into and onto NS).…”
Section: Preparation Of Chitosan-modified Plga Ns Containing Decoy Odnmentioning
confidence: 99%
“…A NF-κB decoy therapeutic system using a synthetic double stranded oligonucleotide to competitively inhibit binding and interaction of NF-κB to their target genoms and prevent the gene induction, transcription and production of the proinflammatory cytokines, is already presented in the literature as promising therapy for IBD and other inflammatory diseases. Successful intracellular and intranuclear delivery of the stable NF-κB decoy to the site of inflammation and action in GI tract is a field yet to be explored (Tahara et al, 2011). Finaly, RNA interference therapy utilizing short interfering (siRNA), usually composed of 20-25 nucleotides targeted to cytosol will trigger gene silencing mechanism through RNA interference where siRNA can block the expression of a specific gene (TNF-or different proinflammatory gene expression in IBD) and proinflammatory protein synthesis, thus providing for successful therapeutic approach in IBD (Kriegel & Amiji, 2011).…”
Section: Biological and Gene Therapies For Inflammatory Bowel Diseasesmentioning
confidence: 99%
“…Additionally, decoy ODN-loaded chitosan-PLGA nanospheres were shown to more effectively deposited and adsorb on the inflamed ulcerative colitis model rats mucosal tissue. Based on results, authors concluded that oral administration of NF-jB decoy ODN-loaded chitosan modified PLGA nanospheres represent a promising carrier for treatment of ulcerative colitis (Tahara et al, 2011).…”
Section: Novel Engineered Nanomaterial-based Nf-jb Decoy Odn Deliverymentioning
confidence: 99%
“…Chitosan in formulation demonstrates low solubility in physiological pH and low-transfection efficiency (Borchard, 2001;Bozkir & Saka, 2004;Prabaharan & Mano, 2004; Chitosan-modified PLGA NS Increased mucoadhesion, protection against acidic medium, suitability for oral delivery, prolonged release profile - (Tahara et al, 2011) PEI Unique DNA condensation capability; unique proton-sponge effect; high buffering capacity and transfection efficiency;…”
Section: Disclosure Statementmentioning
confidence: 99%