Oral Mukozal Mali̇gn Melanoma : Olgu Sunumu

Malignant Melanoma

“…Oral melanomas are extremely rare, aggressive and they are silent progressive neoplasms. 3,9,11 80% of the cases are localized on maxillary gingiva, hard palate and alveolar crest, while about 20% are localized on mandibular. 11 They may occur on buccal mucosa, lips, tongue and floor of the mouth in the mandible which is rare.…”

“…2 However, it is frequently on hard palate region. [9][10][11] In this case the lesion was on hard palate and because the development of lesion was asymptomatic, the patient applied late to clinic.…”

“…It behaves like acral lentigenous melanoma. 9,20 Mucosal melanomas should be investigate for V600 BRAF mutation, and for those patients without this mutation, KIT mutation should be analyzed. 21 BRAF mutation is detected in 10% of mucosal melanomas while KIT mutation is detected 25% and targeted treatment (imatinib) is applied.…”

“…1,3 Melanomas are asymptomatic in clinical appearance and progress quietly. 3,8,9 About 60% of patients are detected incidentally during routine dental examination. 8 This may cause late diagnose and radical treatment may be needed.…”

“…8 This may cause late diagnose and radical treatment may be needed. 3,9 In early stages, pigmented and irregularly bounded, superficial lesions are seen in the skin and mucosa. 2,10 First, the lesions begins as small macular, nonswollen, then it expands.…”