Oral Mucositis Prevention By Low-Level Laser Therapy in Head-and-Neck Cancer Patients Undergoing Concurrent Chemoradiotherapy: A Phase III Randomized Study

Systematic review of laser and other light therapy for the management of oral mucositis in cancer patients

“…A recent randomized study in patients with malignancies treated with HSCT confirmed that oral mucositis incidence and severity can be reduced with LLLT [46]. Late-breaking studies also showed positive outcomes on the prevention and treatment of oral mucositis in head and neck cancer populations being treated with radiation therapy [47], and in prevention of oral mucositis in head and neck cancer populations being treated with concurrent chemoradiation, indicating that this technology seems to be effective in controlling the appearance and severity of OM, its associated pain, and it can also have beneficial effects on quality of life [46,48,49].…”

Current indications for low level laser treatment in maxillofacial surgery: a review

“…Seven studies were excluded from the final results because we could not interpret the data. [6][7][8][9][10][11][12] Thirty-five high quality studies were found, which covered 12 indications including alveolar osteitis, dentin hypersensitivity, oral mucositis, gingival healing, bisphosphonateinduced osteonecrosis, periodontitis, dental pain, xerostomia, disorders of the temporomandibular joint (TMJ), orthodontic tooth movements, myofascial pain, and regeneration of bone after maxillary expansion ( Table 2).…”

Oral mucositis and saliva IgA, IgG and IgM concentration during anti-tumor treatment in children suffering from acute lymphoblastic leukemia

“…3,5 Certain agents have been examined for prevention or treatment of oral mucositis caused by chemotherapy or radiotherapy, but none of them has been confirmed as fully effective. 27 A study by Pereira Pinto et al revealed that in a group of children with ALL who used 0.12% chlorhexidine gluconate to rinse the mouth, 26% developed mucositis in comparison with 80% who did not use the oral rinse. 28 Initially, the lesions were manifested as a characteristic erythema on the buccal and labial mucosa, followed by edema and ulceration.…”